Modular Diazo Compound for the Bioreversible Late-Stage Modification of Proteins

We introduce a versatile strategy for the bioreversible modification of proteins. Our strategy is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo moiety for chemoselective esterification of carboxyl groups, a pyridyl disulfide group for late-stage functionaliz...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-03, Vol.145 (12), p.6615-6621
Hauptverfasser:	Jun, Joomyung V., Petri, Yana D., Erickson, Lucas W., Raines, Ronald T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azo Compounds Cell-Penetrating Peptides - metabolism Esterases - metabolism Esterification Green Fluorescent Proteins - chemistry Mammals - metabolism
Online-Zugang:	Volltext
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