Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Glioblastoma (GBM) is one of the most malignant cancers of central nervous system and due to its sensitive location, surgical resection has high risk and therefore, chemotherapy and radiotherapy are utilized for its treatment. However, chemoresistance and radio-resistance are other problems in GBM t...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-02, Vol.158, p.114204-114204, Article 114204
Hauptverfasser:	Hashemi, Mehrdad, Etemad, Sara, Rezaei, Sahar, Ziaolhagh, Setayesh, Rajabi, Romina, Rahmanian, Parham, Abdi, Soheila, Koohpar, Zeinab Khazaei, Rafiei, Reihaneh, Raei, Behnaz, Ahmadi, Fatemeh, Salimimoghadam, Shokooh, Aref, Amir Reza, Zandieh, Mohammad Arad, Entezari, Maliheh, Taheriazam, Afshin, Hushmandi, Kiavash
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapy Cell Line, Tumor Cell Proliferation Drug resistance Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Humans Non-coding RNAs Phosphatidylinositol 3-Kinases - metabolism Prognosis Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN/PI3K/Akt Signal Transduction - physiology
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