Efficacy and Safety of Low-dose Spironolactone for Chronic Kidney Disease in Type 2 Diabetes

Abstract Context Although adding spironolactone to renin-angiotensin system blockers reduces albuminuria in adults with chronic kidney disease and type 2 diabetes, it increases the risk of hyperkalemia. Objective To assess whether a lower dose of spironolactone (12.5 mg/d) reduces the risk of hyperk...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2023-08, Vol.108 (9), p.2203-2210
Hauptverfasser:	Oiwa, Ako, Hiwatashi, Dai, Takeda, Teiji, Miyamoto, Takahide, Kawata, Iori, Koinuma, Masayoshi, Yamazaki, Masanori, Komatsu, Mitsuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Creatinine Diabetes Diabetes mellitus (non-insulin dependent) Glomerular filtration rate Hyperkalemia Kidney diseases Mineralocorticoid receptors Potassium Renin Statistical analysis
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