Disulfiram enhances cisplatin cytotoxicity by forming a novel platinum chelate Pt(DDTC)3

Schematic of the process for cisplatin sensitizer screening (left), identifying a novel platinum chelate Pt(DDTC)3+ from the mixture of DDP and DSF (middle), and verifying antitumor effect of Pt(DDTC)3+ (right). [Display omitted] Despite the use of targeted therapy in non-small cell lung cancer (NSC...

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Veröffentlicht in:	Biochemical pharmacology 2023-05, Vol.211, p.115498-115498, Article 115498
Hauptverfasser:	Yuan, Xue-xia, Duan, You-fa, Luo, Chunxiang, Li, Lu, Yang, Meng-jie, Liu, Ting-yu, Cao, Zhi-rui, Huang, Wenlin, Bu, Xianzhang, Yue, Xin, Liu, Ran-yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell Proliferation Cisplatin Cisplatin - metabolism Cisplatin - pharmacology Disulfiram Disulfiram - pharmacology Drug Resistance, Neoplasm Humans Lung Neoplasms - metabolism Mice Non-small cell lung cancer Platinum - pharmacology Platinum(IV) chelate Pt(DDTC)3
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