Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6
We evaluated antitumor efficacy of photodynamic therapy of murine Ehrlich carcinoma and rat sarcoma M-1 with new photosensitizers 13 1 - N -(4-aminobutyl)amydo chlorine e6 ( 1 ), 13 2 -(5-guanidylbutanamido)-chlorine e6 ( 2 ), and 13 2 -(5-biguanidylbutanamido)-chlorine e6 ( 3 ). The inhibiting effe...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2023-02, Vol.174 (4), p.468-472 |
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| creator | Abramova, O. B. Kozlovtseva, E. A. Drozhzhina, V. V. Ostroverkhov, P. V. Sivovolova, T. P. Arkhipova, L. M. Grin, M. A. Ivanov, S. A. Kaprin, A. D. |
| description | We evaluated antitumor efficacy of photodynamic therapy of murine Ehrlich carcinoma and rat sarcoma M-1 with new photosensitizers 13
1
-
N
-(4-aminobutyl)amydo chlorine
e6
(
1
), 13
2
-(5-guanidylbutanamido)-chlorine
e6
(
2
), and 13
2
-(5-biguanidylbutanamido)-chlorine
e6
(
3
). The inhibiting effect of the photodynamic therapy was evaluated by the following parameters: tumor growth inhibition, complete regression of the tumors, and absolute growth rate of the tumor nodes in animals with the continued neoplasia growth. The criterion of cure was the absence of tumors up to 90 days after the therapy. It is shown that the studied photosensitizers have high antitumor activity in the photodynamic therapy of the Ehrlich carcinoma and sarcoma M-1. |
| doi_str_mv | 10.1007/s10517-023-05731-3 |
| format | Article |
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1
-
N
-(4-aminobutyl)amydo chlorine
e6
(
1
), 13
2
-(5-guanidylbutanamido)-chlorine
e6
(
2
), and 13
2
-(5-biguanidylbutanamido)-chlorine
e6
(
3
). The inhibiting effect of the photodynamic therapy was evaluated by the following parameters: tumor growth inhibition, complete regression of the tumors, and absolute growth rate of the tumor nodes in animals with the continued neoplasia growth. The criterion of cure was the absence of tumors up to 90 days after the therapy. It is shown that the studied photosensitizers have high antitumor activity in the photodynamic therapy of the Ehrlich carcinoma and sarcoma M-1.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-023-05731-3</identifier><identifier>PMID: 36913091</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Animals, Laboratory ; Antitumor activity ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Carcinoma - drug therapy ; Care and treatment ; Cell Biology ; Chlorine ; Cytotoxicity ; Drug dosages ; Growth inhibition ; Growth rate ; Guanidine ; Guanidines ; Internal Medicine ; Laboratory animals ; Laboratory Medicine ; Lasers ; Medical research ; Mice ; Oncology ; Pathology ; Photochemotherapy ; Photodynamic therapy ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - therapeutic use ; Porphyrins - pharmacology ; Sarcoma ; Solid tumors ; Tumors</subject><ispartof>Bulletin of experimental biology and medicine, 2023-02, Vol.174 (4), p.468-472</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-7ca2bac1f937f2afc1c61af0f79cba8ba263aee27c01b73dd8dec89d773a07453</citedby><cites>FETCH-LOGICAL-c473t-7ca2bac1f937f2afc1c61af0f79cba8ba263aee27c01b73dd8dec89d773a07453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-023-05731-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-023-05731-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36913091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abramova, O. B.</creatorcontrib><creatorcontrib>Kozlovtseva, E. A.</creatorcontrib><creatorcontrib>Drozhzhina, V. V.</creatorcontrib><creatorcontrib>Ostroverkhov, P. V.</creatorcontrib><creatorcontrib>Sivovolova, T. P.</creatorcontrib><creatorcontrib>Arkhipova, L. M.</creatorcontrib><creatorcontrib>Grin, M. A.</creatorcontrib><creatorcontrib>Ivanov, S. A.</creatorcontrib><creatorcontrib>Kaprin, A. D.</creatorcontrib><title>Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We evaluated antitumor efficacy of photodynamic therapy of murine Ehrlich carcinoma and rat sarcoma M-1 with new photosensitizers 13
1
-
N
-(4-aminobutyl)amydo chlorine
e6
(
1
), 13
2
-(5-guanidylbutanamido)-chlorine
e6
(
2
), and 13
2
-(5-biguanidylbutanamido)-chlorine
e6
(
3
). The inhibiting effect of the photodynamic therapy was evaluated by the following parameters: tumor growth inhibition, complete regression of the tumors, and absolute growth rate of the tumor nodes in animals with the continued neoplasia growth. The criterion of cure was the absence of tumors up to 90 days after the therapy. It is shown that the studied photosensitizers have high antitumor activity in the photodynamic therapy of the Ehrlich carcinoma and sarcoma M-1.</description><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Antitumor activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Carcinoma - drug therapy</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Chlorine</subject><subject>Cytotoxicity</subject><subject>Drug dosages</subject><subject>Growth inhibition</subject><subject>Growth rate</subject><subject>Guanidine</subject><subject>Guanidines</subject><subject>Internal Medicine</subject><subject>Laboratory animals</subject><subject>Laboratory Medicine</subject><subject>Lasers</subject><subject>Medical research</subject><subject>Mice</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Porphyrins - pharmacology</subject><subject>Sarcoma</subject><subject>Solid tumors</subject><subject>Tumors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks1u1DAUhSMEokPhBVggS0iomxT_JHGynA6lII0EEsPaunHsiavEHmynaJ6Bl64zU0qLEPLCvtffOfLPybLXBJ8TjPn7QHBJeI4py3HJGcnZk2xB0iqvKSVPswVOVF7UdX2SvQjhei5xRZ5nJ6xqCMMNWWS_ljaafDONzqNLrY0EuUdOo6-9i67bWxiNRJteedgd-t_cYDp04AMyFq2hdR6i83u0tGaEIaCfJvboagJrOmMVAtuhC7O9rz8ob24gmhsVZsNVPzg_91X1Mnumk4F6dTefZt8_Xm5Wn_L1l6vPq-U6lwVnMecSaAuS6IZxTUFLIisCGmveyBbqFmjFQCnKJSYtZ11Xd0rWTcc5A8yLkp1mZ0ffnXc_JhWiGE2QahjAKjcFQXldlaSqKUno27_Qazd5m043U5yXlBcPqC0MShirXfQgZ1Ox5EVTEEoalqjzf1BpdCo9srNKm9R_JHj3QNArGGIf3DBF42x4DNIjKL0LwSstdj79hd8LgsUcFXGMikhREYeoiFn05u5qUzuq7l7yOxsJYEcgpC27Vf7P3f9jewtazciZ</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Abramova, O. 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D.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20230201</creationdate><title>Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6</title><author>Abramova, O. B. ; Kozlovtseva, E. A. ; Drozhzhina, V. V. ; Ostroverkhov, P. V. ; Sivovolova, T. P. ; Arkhipova, L. M. ; Grin, M. A. ; Ivanov, S. A. ; Kaprin, A. 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B.</creatorcontrib><creatorcontrib>Kozlovtseva, E. A.</creatorcontrib><creatorcontrib>Drozhzhina, V. V.</creatorcontrib><creatorcontrib>Ostroverkhov, P. V.</creatorcontrib><creatorcontrib>Sivovolova, T. P.</creatorcontrib><creatorcontrib>Arkhipova, L. M.</creatorcontrib><creatorcontrib>Grin, M. A.</creatorcontrib><creatorcontrib>Ivanov, S. A.</creatorcontrib><creatorcontrib>Kaprin, A. 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B.</au><au>Kozlovtseva, E. A.</au><au>Drozhzhina, V. V.</au><au>Ostroverkhov, P. V.</au><au>Sivovolova, T. P.</au><au>Arkhipova, L. M.</au><au>Grin, M. A.</au><au>Ivanov, S. A.</au><au>Kaprin, A. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>174</volume><issue>4</issue><spage>468</spage><epage>472</epage><pages>468-472</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We evaluated antitumor efficacy of photodynamic therapy of murine Ehrlich carcinoma and rat sarcoma M-1 with new photosensitizers 13
1
-
N
-(4-aminobutyl)amydo chlorine
e6
(
1
), 13
2
-(5-guanidylbutanamido)-chlorine
e6
(
2
), and 13
2
-(5-biguanidylbutanamido)-chlorine
e6
(
3
). The inhibiting effect of the photodynamic therapy was evaluated by the following parameters: tumor growth inhibition, complete regression of the tumors, and absolute growth rate of the tumor nodes in animals with the continued neoplasia growth. The criterion of cure was the absence of tumors up to 90 days after the therapy. It is shown that the studied photosensitizers have high antitumor activity in the photodynamic therapy of the Ehrlich carcinoma and sarcoma M-1.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36913091</pmid><doi>10.1007/s10517-023-05731-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bulletin of experimental biology and medicine, 2023-02, Vol.174 (4), p.468-472 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| subjects | Animals Animals, Laboratory Antitumor activity Biomedical and Life Sciences Biomedicine Cancer Carcinoma - drug therapy Care and treatment Cell Biology Chlorine Cytotoxicity Drug dosages Growth inhibition Growth rate Guanidine Guanidines Internal Medicine Laboratory animals Laboratory Medicine Lasers Medical research Mice Oncology Pathology Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Porphyrins - pharmacology Sarcoma Solid tumors Tumors |
| title | Anti-Tumor Efficacy of Photodynamic Therapy of Solid Tumors in Laboratory Animals with Guanidine and Biguanidine Derivatives of Chlorine e6 |
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