Evaluation of catch-up growth in severe pediatric Hashimoto's hypothyroidism
We aimed to evaluate catch-up growth in children with severe Hashimoto's hypothyroidism (HH) after thyroid hormone replacement therapy (HRT). A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017. A...
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| Veröffentlicht in: | Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2023-04, Vol.30 (3), p.142-148 |
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| creator | Vincent, A. Bouvattier, C. Teinturier, C. Rodrigue, D. Busiah, K. Olivier-Petit, I. Bony, H. Barat, P. Cammas, B. Coutant, R. Lienhardt, A. Linglart, A. Lambert, A.-S. |
| description | We aimed to evaluate catch-up growth in children with severe Hashimoto's hypothyroidism (HH) after thyroid hormone replacement therapy (HRT).
A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017.
A total of 29 patients were included, with a median age of 9.7 years (13–172 months). Median height at diagnosis was -2.7 [-4.6; -0.1] standard deviation score (SDS), with a height loss of 2.5 [0.7; 5.4] SDS compared to height before growth deflection (p |
| doi_str_mv | 10.1016/j.arcped.2023.01.001 |
| format | Article |
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A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017.
A total of 29 patients were included, with a median age of 9.7 years (13–172 months). Median height at diagnosis was -2.7 [-4.6; -0.1] standard deviation score (SDS), with a height loss of 2.5 [0.7; 5.4] SDS compared to height before growth deflection (p<0.0001). At diagnosis, the median TSH level was 819.5 mIU/L [100; 1844], the median FT4 level was 0 pmol/L [undetectable; 5.4], and the median anti-thyroperoxidase antibody level was 1601 UI/L [47; 25,500].
In the 20 patients treated only with HRT, there were significant differences between height at diagnosis and height at 1 year (n = 19, p<0.0001), 2 years (n = 13, p = 0.0005), 3 years (n = 9, p = 0.0039), 4 years (n = 10, p = 0.0078), and 5 years (n = 10, p = 0.0018) of treatment but not in the case of final height (n = 6, p = 0.0625). Median final height was -1.4 [-2.7; 1,5] SDS (n = 6), with a significant difference between height loss at diagnosis and total catch-up growth (p = 0.003).
The other nine patients were also given growth hormone (GH). They were smaller at diagnosis (p = 0.01); however, there was no difference in final height between those two groups (p = 0.68).
Severe HH can lead to a major height deficit, and catch-up growth seems to be insufficient after treatment with HRT alone. In the most severe cases, administration of GH may enhance this catch-up.</description><identifier>ISSN: 0929-693X</identifier><identifier>EISSN: 1769-664X</identifier><identifier>DOI: 10.1016/j.arcped.2023.01.001</identifier><identifier>PMID: 36907727</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Body Height ; Catch-up growth ; Child ; Children ; Growth Disorders - etiology ; Growth hormone ; Hashimoto's hypothyroidism ; Human Growth Hormone ; Humans ; Hypothyroidism - diagnosis ; Hypothyroidism - drug therapy ; Iodide Peroxidase ; Retrospective Studies</subject><ispartof>Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 2023-04, Vol.30 (3), p.142-148</ispartof><rights>2023 French Society of Pediatrics</rights><rights>Copyright © 2023 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c357t-e1aa44bbc3fa99afe6b9768c7597ba19d32fd2163e704707144f7ccd9486f1203</cites><orcidid>0000-0002-1059-0791</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.arcped.2023.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36907727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, A.</creatorcontrib><creatorcontrib>Bouvattier, C.</creatorcontrib><creatorcontrib>Teinturier, C.</creatorcontrib><creatorcontrib>Rodrigue, D.</creatorcontrib><creatorcontrib>Busiah, K.</creatorcontrib><creatorcontrib>Olivier-Petit, I.</creatorcontrib><creatorcontrib>Bony, H.</creatorcontrib><creatorcontrib>Barat, P.</creatorcontrib><creatorcontrib>Cammas, B.</creatorcontrib><creatorcontrib>Coutant, R.</creatorcontrib><creatorcontrib>Lienhardt, A.</creatorcontrib><creatorcontrib>Linglart, A.</creatorcontrib><creatorcontrib>Lambert, A.-S.</creatorcontrib><title>Evaluation of catch-up growth in severe pediatric Hashimoto's hypothyroidism</title><title>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</title><addtitle>Arch Pediatr</addtitle><description>We aimed to evaluate catch-up growth in children with severe Hashimoto's hypothyroidism (HH) after thyroid hormone replacement therapy (HRT).
A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017.
A total of 29 patients were included, with a median age of 9.7 years (13–172 months). Median height at diagnosis was -2.7 [-4.6; -0.1] standard deviation score (SDS), with a height loss of 2.5 [0.7; 5.4] SDS compared to height before growth deflection (p<0.0001). At diagnosis, the median TSH level was 819.5 mIU/L [100; 1844], the median FT4 level was 0 pmol/L [undetectable; 5.4], and the median anti-thyroperoxidase antibody level was 1601 UI/L [47; 25,500].
In the 20 patients treated only with HRT, there were significant differences between height at diagnosis and height at 1 year (n = 19, p<0.0001), 2 years (n = 13, p = 0.0005), 3 years (n = 9, p = 0.0039), 4 years (n = 10, p = 0.0078), and 5 years (n = 10, p = 0.0018) of treatment but not in the case of final height (n = 6, p = 0.0625). Median final height was -1.4 [-2.7; 1,5] SDS (n = 6), with a significant difference between height loss at diagnosis and total catch-up growth (p = 0.003).
The other nine patients were also given growth hormone (GH). They were smaller at diagnosis (p = 0.01); however, there was no difference in final height between those two groups (p = 0.68).
Severe HH can lead to a major height deficit, and catch-up growth seems to be insufficient after treatment with HRT alone. In the most severe cases, administration of GH may enhance this catch-up.</description><subject>Body Height</subject><subject>Catch-up growth</subject><subject>Child</subject><subject>Children</subject><subject>Growth Disorders - etiology</subject><subject>Growth hormone</subject><subject>Hashimoto's hypothyroidism</subject><subject>Human Growth Hormone</subject><subject>Humans</subject><subject>Hypothyroidism - diagnosis</subject><subject>Hypothyroidism - drug therapy</subject><subject>Iodide Peroxidase</subject><subject>Retrospective Studies</subject><issn>0929-693X</issn><issn>1769-664X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFLwzAQx4Mobk6_gUjf9KX10nRJ8yLImE4Y-KKwt5Cmqc1Yl5qkk317MzZffbqD-939uR9CtxgyDJg-rjPpVK_rLIecZIAzAHyGxphRnlJarM7RGHgee05WI3Tl_RoASijJJRoRyoGxnI3Rcr6Tm0EGY7eJbRIlg2rToU--nP0JbWK2idc77XQSk4wMzqhkIX1rOhvsvU_afW9Du3fW1MZ31-iikRuvb051gj5f5h-zRbp8f32bPS9TRaYspBpLWRRVpUgjOZeNphVntFRsylklMa9J3tQ5pkQzKBgwXBQNU6rmRUkbnAOZoIfj3d7Z70H7IDrjld5s5FbbwYuclXSKcVlOI1ocUeWs9043onemk24vMIiDR7EWR4_i4FEAFtFjXLs7JQxVF2d_S3_iIvB0BHT8c2e0E14ZvVXRktMqiNqa_xN-AfxPhm8</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Vincent, A.</creator><creator>Bouvattier, C.</creator><creator>Teinturier, C.</creator><creator>Rodrigue, D.</creator><creator>Busiah, K.</creator><creator>Olivier-Petit, I.</creator><creator>Bony, H.</creator><creator>Barat, P.</creator><creator>Cammas, B.</creator><creator>Coutant, R.</creator><creator>Lienhardt, A.</creator><creator>Linglart, A.</creator><creator>Lambert, A.-S.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1059-0791</orcidid></search><sort><creationdate>202304</creationdate><title>Evaluation of catch-up growth in severe pediatric Hashimoto's hypothyroidism</title><author>Vincent, A. ; Bouvattier, C. ; Teinturier, C. ; Rodrigue, D. ; Busiah, K. ; Olivier-Petit, I. ; Bony, H. ; Barat, P. ; Cammas, B. ; Coutant, R. ; Lienhardt, A. ; Linglart, A. ; Lambert, A.-S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e1aa44bbc3fa99afe6b9768c7597ba19d32fd2163e704707144f7ccd9486f1203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body Height</topic><topic>Catch-up growth</topic><topic>Child</topic><topic>Children</topic><topic>Growth Disorders - etiology</topic><topic>Growth hormone</topic><topic>Hashimoto's hypothyroidism</topic><topic>Human Growth Hormone</topic><topic>Humans</topic><topic>Hypothyroidism - diagnosis</topic><topic>Hypothyroidism - drug therapy</topic><topic>Iodide Peroxidase</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincent, A.</creatorcontrib><creatorcontrib>Bouvattier, C.</creatorcontrib><creatorcontrib>Teinturier, C.</creatorcontrib><creatorcontrib>Rodrigue, D.</creatorcontrib><creatorcontrib>Busiah, K.</creatorcontrib><creatorcontrib>Olivier-Petit, I.</creatorcontrib><creatorcontrib>Bony, H.</creatorcontrib><creatorcontrib>Barat, P.</creatorcontrib><creatorcontrib>Cammas, B.</creatorcontrib><creatorcontrib>Coutant, R.</creatorcontrib><creatorcontrib>Lienhardt, A.</creatorcontrib><creatorcontrib>Linglart, A.</creatorcontrib><creatorcontrib>Lambert, A.-S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincent, A.</au><au>Bouvattier, C.</au><au>Teinturier, C.</au><au>Rodrigue, D.</au><au>Busiah, K.</au><au>Olivier-Petit, I.</au><au>Bony, H.</au><au>Barat, P.</au><au>Cammas, B.</au><au>Coutant, R.</au><au>Lienhardt, A.</au><au>Linglart, A.</au><au>Lambert, A.-S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of catch-up growth in severe pediatric Hashimoto's hypothyroidism</atitle><jtitle>Archives de pédiatrie : organe officiel de la Société française de pédiatrie</jtitle><addtitle>Arch Pediatr</addtitle><date>2023-04</date><risdate>2023</risdate><volume>30</volume><issue>3</issue><spage>142</spage><epage>148</epage><pages>142-148</pages><issn>0929-693X</issn><eissn>1769-664X</eissn><abstract>We aimed to evaluate catch-up growth in children with severe Hashimoto's hypothyroidism (HH) after thyroid hormone replacement therapy (HRT).
A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017.
A total of 29 patients were included, with a median age of 9.7 years (13–172 months). Median height at diagnosis was -2.7 [-4.6; -0.1] standard deviation score (SDS), with a height loss of 2.5 [0.7; 5.4] SDS compared to height before growth deflection (p<0.0001). At diagnosis, the median TSH level was 819.5 mIU/L [100; 1844], the median FT4 level was 0 pmol/L [undetectable; 5.4], and the median anti-thyroperoxidase antibody level was 1601 UI/L [47; 25,500].
In the 20 patients treated only with HRT, there were significant differences between height at diagnosis and height at 1 year (n = 19, p<0.0001), 2 years (n = 13, p = 0.0005), 3 years (n = 9, p = 0.0039), 4 years (n = 10, p = 0.0078), and 5 years (n = 10, p = 0.0018) of treatment but not in the case of final height (n = 6, p = 0.0625). Median final height was -1.4 [-2.7; 1,5] SDS (n = 6), with a significant difference between height loss at diagnosis and total catch-up growth (p = 0.003).
The other nine patients were also given growth hormone (GH). They were smaller at diagnosis (p = 0.01); however, there was no difference in final height between those two groups (p = 0.68).
Severe HH can lead to a major height deficit, and catch-up growth seems to be insufficient after treatment with HRT alone. In the most severe cases, administration of GH may enhance this catch-up.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>36907727</pmid><doi>10.1016/j.arcped.2023.01.001</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1059-0791</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives de pédiatrie : organe officiel de la Société française de pédiatrie, 2023-04, Vol.30 (3), p.142-148 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Body Height Catch-up growth Child Children Growth Disorders - etiology Growth hormone Hashimoto's hypothyroidism Human Growth Hormone Humans Hypothyroidism - diagnosis Hypothyroidism - drug therapy Iodide Peroxidase Retrospective Studies |
| title | Evaluation of catch-up growth in severe pediatric Hashimoto's hypothyroidism |
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