Oral lymphatic delivery of alpha-galactosylceramide and ovalbumin evokes anti-cancer immunization

We developed an orally delivered nanoemulsion that induces cancer immunization. It consists of tumor antigen-loaded nano-vesicles carrying the potent invariant natural killer T-cell (iNKT) activator α-galactosylceramide (α-GalCer), to trigger cancer immunity by effectively activating both innate and...

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Veröffentlicht in:	Journal of controlled release 2023-04, Vol.356, p.507-524
Hauptverfasser:	Pandey, Prashant, Kim, Seung Hyun, Subedi, Laxman, Mujahid, Khizra, Kim, Yebon, Cho, Young-Chang, Shim, Jung-Hyun, Kim, Ki-Taek, Cho, Seung-Sik, Choi, Jeong Uk, Park, Jin Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-galactosylceramide Animals Antigens, Neoplasm bile Bile acid transporter-mediated oral absorption bioavailability blood serum cytotoxicity deoxycholic acid humoral immunity immune response Immunization immunoglobulin G Intestinal lymphatic transport intestines lipids lymph macrophages Melanoma Mice Mice, Inbred C57BL Nanoemulsion nanoemulsions oils oral administration Oral cancer immunization Ovalbumin permeability propane T-lymphocytes vaccination
Online-Zugang:	Volltext
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