Use of Clinical Trial Simulations to Compare the Performance of Different Approaches for Population Analyses of Pediatric Pharmacokinetic Data

The adequate characterization of the pharmacokinetics of a drug used in pediatrics is a mainstay of pediatric development programs and is critical for accurate dose selection in pediatrics. Analysis approaches can impact the estimation and characterization of pediatric pharmacokinetic parameters. Si...

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Veröffentlicht in:	Journal of clinical pharmacology 2023-07, Vol.63 (7), p.859-868
Hauptverfasser:	Temrikar, Zaid, Muensterman, Elena, Engelhardt, Benjamin, Mohamed, Mohamed‐Eslam F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian analysis Body weight clinical trial simulations Clinical trials Datasets Drug development Pediatrics Pharmacokinetics pharmacometrics
Online-Zugang:	Volltext
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