Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder
Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalenc...
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| Veröffentlicht in: | Drug and alcohol dependence 2023-04, Vol.245, p.109822-109822, Article 109822 |
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| creator | Hernández-Rubio, Anna Sanvisens, Arantza Barbier-Torres, Lucía Blanes, Rafael Miquel, Laia Torrens, Marta Rubio, Gabriel Bolao, Ferran Zuluaga, Paola Fuster, Daniel Rodríguez de Fonseca, Fernando Farré, Magí Muga, Robert Study, CohRTA Center, Coordinating Sanvisens, Arantza Zuluaga, Paola Fuster, Daniel Hernández-Rubio, Anna Farré, Magí Papasseit, Esther Pérez-Mañá, Clara Poyatos, Lourdes García-Marchena, Nuria Abellí, Enric Muga, Robert Short, Antonio Moranta, Catalina Blanes, Rafael Rubio, Gabriel Sion, Ana Miquel, Laia Ortega, Lluisa Bruguera, Pol Caballeria, Elsa Messeguer, Ana Torrens, Marta Fonseca, Francina Ignacio Mestre-Pinto, Juan Alías, María Dinamarca, Fernando Bolao, Ferran Rodríguez de Fonseca, Fernando Javier Pavón-Morón, Francisco Araos, Pedro Flores-López, María Serrano, Antonia Marcos, Miguel Martín, Candelaria Pérez-Hernández, Onán Manzanares, Jorge Illescas, Lucía |
| description | Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.
Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.
753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) |
| doi_str_mv | 10.1016/j.drugalcdep.2023.109822 |
| format | Article |
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Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.
753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg.
Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
•Serum hypomagnesemia is the most common electrolyte disturbance in patients with AUD.•Liver damage and glomerular dysfunction were associated with hypomagnesemia in patients with AUD.•Hypomagnesemia is several times more likely to occur among AUD patients with hyponatremia or hypokalemia.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2023.109822</identifier><identifier>PMID: 36893509</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Alcohol Drinking ; Alcohol use disorder ; Alcoholism - epidemiology ; Alcoholism - therapy ; Cross-Sectional Studies ; Electrolyte disturbances ; Female ; Humans ; Liver Cirrhosis - complications ; Magnesium ; Magnesium deficiency ; Male ; Middle Aged ; Oxidative stress</subject><ispartof>Drug and alcohol dependence, 2023-04, Vol.245, p.109822-109822, Article 109822</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c369t-878732c4d55dffcc0952d0b6b3673a49bd45575555b18e55762f74c5dd581bd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871623000601$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36893509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández-Rubio, Anna</creatorcontrib><creatorcontrib>Sanvisens, Arantza</creatorcontrib><creatorcontrib>Barbier-Torres, Lucía</creatorcontrib><creatorcontrib>Blanes, Rafael</creatorcontrib><creatorcontrib>Miquel, Laia</creatorcontrib><creatorcontrib>Torrens, Marta</creatorcontrib><creatorcontrib>Rubio, Gabriel</creatorcontrib><creatorcontrib>Bolao, Ferran</creatorcontrib><creatorcontrib>Zuluaga, Paola</creatorcontrib><creatorcontrib>Fuster, Daniel</creatorcontrib><creatorcontrib>Rodríguez de Fonseca, Fernando</creatorcontrib><creatorcontrib>Farré, Magí</creatorcontrib><creatorcontrib>Muga, Robert</creatorcontrib><creatorcontrib>Study, CohRTA</creatorcontrib><creatorcontrib>Center, Coordinating</creatorcontrib><creatorcontrib>Sanvisens, Arantza</creatorcontrib><creatorcontrib>Zuluaga, Paola</creatorcontrib><creatorcontrib>Fuster, Daniel</creatorcontrib><creatorcontrib>Hernández-Rubio, Anna</creatorcontrib><creatorcontrib>Farré, Magí</creatorcontrib><creatorcontrib>Papasseit, Esther</creatorcontrib><creatorcontrib>Pérez-Mañá, Clara</creatorcontrib><creatorcontrib>Poyatos, Lourdes</creatorcontrib><creatorcontrib>García-Marchena, Nuria</creatorcontrib><creatorcontrib>Abellí, Enric</creatorcontrib><creatorcontrib>Muga, Robert</creatorcontrib><creatorcontrib>Short, Antonio</creatorcontrib><creatorcontrib>Moranta, Catalina</creatorcontrib><creatorcontrib>Blanes, Rafael</creatorcontrib><creatorcontrib>Rubio, Gabriel</creatorcontrib><creatorcontrib>Sion, Ana</creatorcontrib><creatorcontrib>Miquel, Laia</creatorcontrib><creatorcontrib>Ortega, Lluisa</creatorcontrib><creatorcontrib>Bruguera, Pol</creatorcontrib><creatorcontrib>Caballeria, Elsa</creatorcontrib><creatorcontrib>Messeguer, Ana</creatorcontrib><creatorcontrib>Torrens, Marta</creatorcontrib><creatorcontrib>Fonseca, Francina</creatorcontrib><creatorcontrib>Ignacio Mestre-Pinto, Juan</creatorcontrib><creatorcontrib>Alías, María</creatorcontrib><creatorcontrib>Dinamarca, Fernando</creatorcontrib><creatorcontrib>Bolao, Ferran</creatorcontrib><creatorcontrib>Rodríguez de Fonseca, Fernando</creatorcontrib><creatorcontrib>Javier Pavón-Morón, Francisco</creatorcontrib><creatorcontrib>Araos, Pedro</creatorcontrib><creatorcontrib>Flores-López, María</creatorcontrib><creatorcontrib>Serrano, Antonia</creatorcontrib><creatorcontrib>Marcos, Miguel</creatorcontrib><creatorcontrib>Martín, Candelaria</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Manzanares, Jorge</creatorcontrib><creatorcontrib>Illescas, Lucía</creatorcontrib><creatorcontrib>on behalf of CohRTA</creatorcontrib><creatorcontrib>CohRTA</creatorcontrib><title>Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.
Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.
753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg.
Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
•Serum hypomagnesemia is the most common electrolyte disturbance in patients with AUD.•Liver damage and glomerular dysfunction were associated with hypomagnesemia in patients with AUD.•Hypomagnesemia is several times more likely to occur among AUD patients with hyponatremia or hypokalemia.</description><subject>Adult</subject><subject>Alcohol Drinking</subject><subject>Alcohol use disorder</subject><subject>Alcoholism - epidemiology</subject><subject>Alcoholism - therapy</subject><subject>Cross-Sectional Studies</subject><subject>Electrolyte disturbances</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Magnesium</subject><subject>Magnesium deficiency</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative 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Francisco</creatorcontrib><creatorcontrib>Araos, Pedro</creatorcontrib><creatorcontrib>Flores-López, María</creatorcontrib><creatorcontrib>Serrano, Antonia</creatorcontrib><creatorcontrib>Marcos, Miguel</creatorcontrib><creatorcontrib>Martín, Candelaria</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Manzanares, Jorge</creatorcontrib><creatorcontrib>Illescas, Lucía</creatorcontrib><creatorcontrib>on behalf of CohRTA</creatorcontrib><creatorcontrib>CohRTA</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández-Rubio, Anna</au><au>Sanvisens, Arantza</au><au>Barbier-Torres, Lucía</au><au>Blanes, Rafael</au><au>Miquel, Laia</au><au>Torrens, Marta</au><au>Rubio, Gabriel</au><au>Bolao, Ferran</au><au>Zuluaga, Paola</au><au>Fuster, Daniel</au><au>Rodríguez de Fonseca, Fernando</au><au>Farré, Magí</au><au>Muga, Robert</au><au>Study, CohRTA</au><au>Center, Coordinating</au><au>Sanvisens, Arantza</au><au>Zuluaga, Paola</au><au>Fuster, Daniel</au><au>Hernández-Rubio, Anna</au><au>Farré, Magí</au><au>Papasseit, Esther</au><au>Pérez-Mañá, Clara</au><au>Poyatos, Lourdes</au><au>García-Marchena, Nuria</au><au>Abellí, Enric</au><au>Muga, Robert</au><au>Short, Antonio</au><au>Moranta, Catalina</au><au>Blanes, Rafael</au><au>Rubio, Gabriel</au><au>Sion, Ana</au><au>Miquel, Laia</au><au>Ortega, Lluisa</au><au>Bruguera, Pol</au><au>Caballeria, Elsa</au><au>Messeguer, Ana</au><au>Torrens, Marta</au><au>Fonseca, Francina</au><au>Ignacio Mestre-Pinto, Juan</au><au>Alías, María</au><au>Dinamarca, Fernando</au><au>Bolao, Ferran</au><au>Rodríguez de Fonseca, Fernando</au><au>Javier Pavón-Morón, Francisco</au><au>Araos, Pedro</au><au>Flores-López, María</au><au>Serrano, Antonia</au><au>Marcos, Miguel</au><au>Martín, Candelaria</au><au>Pérez-Hernández, Onán</au><au>Manzanares, Jorge</au><au>Illescas, Lucía</au><aucorp>on behalf of CohRTA</aucorp><aucorp>CohRTA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>245</volume><spage>109822</spage><epage>109822</epage><pages>109822-109822</pages><artnum>109822</artnum><issn>0376-8716</issn><eissn>1879-0046</eissn><abstract>Hypomagnesemia (hypoMg) has not yet been extensively studied in alcohol use disorder (AUD) . We hypothesize that chronic, excessive alcohol consumption favors oxidative stress and pro-inflammatory alterations that may be exacerbated by hypoMg. The objective of this study was to analyze the prevalence and associations of hypoMg in AUD.
Cross-sectional study in patients admitted for a first treatment of AUD in six tertiary centers between 2013 and 2020. Socio-demographic, alcohol use characteristics, and blood parameters were ascertained at admission.
753 patients (71% men) were eligible; age at admission was 48 years [IQR, 41–56 years]. Prevalence of hypoMg was 11.2%, higher than that observed for hypocalcemia (9.3%), hyponatremia (5.6%), and hypokalemia (2.8%). HypoMg was associated with older age, longer duration of AUD, anemia, higher erythrocyte sedimentation rate, gamma-glutamyl transpeptidase, glucose levels, advanced liver fibrosis (FIB-4 ≥3.25) and estimated glomerular filtration rate (eGFR) < 60 mL/min. In multivariate analysis, advanced liver fibrosis (OR, 8.91; 95% CI, 3.3–23.9) and eGFR < 60 mL (OR, 5.2; 95% CI, 1.0–26.2) were the only factors associated with hypoMg.
Mg deficiency in AUD is associated with liver damage and glomerular dysfunction suggesting that both comorbidities should be assessed in the course of serum hypoMg.
•Serum hypomagnesemia is the most common electrolyte disturbance in patients with AUD.•Liver damage and glomerular dysfunction were associated with hypomagnesemia in patients with AUD.•Hypomagnesemia is several times more likely to occur among AUD patients with hyponatremia or hypokalemia.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36893509</pmid><doi>10.1016/j.drugalcdep.2023.109822</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2023-04, Vol.245, p.109822-109822, Article 109822 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2786102075 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Alcohol Drinking Alcohol use disorder Alcoholism - epidemiology Alcoholism - therapy Cross-Sectional Studies Electrolyte disturbances Female Humans Liver Cirrhosis - complications Magnesium Magnesium deficiency Male Middle Aged Oxidative stress |
| title | Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder |
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