circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c

To explore the diagnostic value of circ-DENN domain containing 4 C (circDENND4C) in epithelial ovarian cancer (EOC) and the corresponding mechanism. We determined the expression of circDENND4C and miR-200b/c in tissues and serum specimens as well as EOC cell lines using qRT-PCR. Basic clinical data,...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2023-12, Vol.55 (1), p.908-919
Hauptverfasser:	Liu, Shuang, Yuan, Limei, Li, Jinzhu, Liu, Yurong, Wang, Haibo, Ren, Xingye
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomarkers, Tumor - genetics CA-125 Antigen - genetics Carcinoma, Ovarian Epithelial - diagnosis Carcinoma, Ovarian Epithelial - genetics circDENND4C/miR-200b/c diagnosis epithelial ovarian cancer Female Humans MicroRNAs - genetics Neoplasms, Glandular and Epithelial - diagnosis Neoplasms, Glandular and Epithelial - genetics Oncology Ovarian Neoplasms - diagnosis Ovarian Neoplasms - genetics proliferation
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