Association of metabolically healthy obesity in young adulthood with myocardial structure and function
Background Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac...
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| Veröffentlicht in: | International Journal of Obesity 2023-05, Vol.47 (5), p.399-405 |
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| creator | Wang, Peng Liu, Menghui Zhuang, Xiaodong Guo, Yue Xiong, Zhenyu He, Lixiang Cai, Xiaojie Chen, Zhuohui Peng, Longyun Liao, Xinxue |
| description | Background
Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.
Methods
A total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age. The participants were grouped by obesity status (body mass index ≥30 kg/m
2
) and poor metabolic health (≥2 criteria for metabolic syndrome) into four metabolic phenotypes as follows: metabolically healthy non-obesity (MHN), MHO, metabolically unhealthy non-obesity (MUN), metabolically unhealthy obesity (MUO). The associations of the metabolic phenotypes (MHN serving as the reference) with left ventricular (LV) structure and function were evaluated using multiple linear regression models.
Results
At baseline, mean age was 25 years, 56.4% were women, and 44.7% were black. After a follow-up 25 years, MUN in young adulthood was associated with worse LV diastolic function (E/é ratio, β [95% CI], 0.73 [0.18, 1.28]), worse systolic function (global longitudinal strain [GLS], 0.60 [0.08, 1.12]) in comparison with MHN. MHO and MUO were associated with LV hypertrophy (LV mass index, 7.49 g/m
2
[4.63, 10.35]; 18.23 g/m
2
[12.47, 23.99], respectively), worse diastolic function (E/é ratio, 0.67 [0.31, 1.02]; 1.47 [0.79, 2.14], respectively), and worse systolic function (GLS, 0.72 [0.38, 1.06]; 1.35 [0.64, 2.05], respectively) in comparison with MHN. These results were consistent in several sensitivity analyses.
Conclusions
In this community-based cohort using data from the CARDIA study, obesity in young adulthood was significantly associated with LV hypertrophy, worse systolic and diastolic function regardless of metabolic status.
Relationship of Baseline Metabolic Phenotypes with Young Adulthood and Midlife Cardiac Structure and Function. Adjusted for year 0 covariates: age, sex, race, educational level, smoking status, drinking status, and physical activity; metabolically healthy non-obesity was used as a reference category for comparison.
†
Criteria for metabolic syndrome are listed in Supplementary Table
S6
. MUN metabolically unhealthy non-obesity, MHO metabolically healthy obesity, LVMi left ventricular mass index, LVEF left ventricular ejection fraction, |
| doi_str_mv | 10.1038/s41366-023-01288-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2786096520</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2807237890</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-7ac78050b843fe3c04a697649edab3b0803304c356306cd0d2ec1c8185c903b93</originalsourceid><addsrcrecordid>eNp9kTtvFTEQRi0URC4X_kCKyFIamoWxvX6VUcRLikQDteX1enMd7a6DH4r23-PLDSCloHIxZ8545kPogsB7Akx9yD1hQnRAWQeEKtWxF2hHeik63mt5hnbAQHbABT9Hr3O-BwDOgb5C50worZtih6brnKMLtoS44jjhxRc7xDk4O88bPng7l8OG4-BzKBsOK95iXe-wHWsrxDjix1AOeNmis2kMdsa5pOpKTR7bdcRTXd1R_Qa9nOyc_dund49-fPr4_eZLd_vt89eb69vO9USXTlonFXAYVM8mzxz0Vmgpeu1HO7ABFDAGvWNcMBBuhJF6R5wiiru2zqDZHr07eR9S_Fl9LmYJ2fl5tquPNRsqlQAtOIWGXj1D72NNa_udoQokZVLpI0VPlEsx5-Qn85DCYtNmCJhjCuaUgmkpmN8pGNaaLp_UdVj8-Lflz9kbwE5AbqX1zqd_s_-j_QXymJMx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2807237890</pqid></control><display><type>article</type><title>Association of metabolically healthy obesity in young adulthood with myocardial structure and function</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wang, Peng ; Liu, Menghui ; Zhuang, Xiaodong ; Guo, Yue ; Xiong, Zhenyu ; He, Lixiang ; Cai, Xiaojie ; Chen, Zhuohui ; Peng, Longyun ; Liao, Xinxue</creator><creatorcontrib>Wang, Peng ; Liu, Menghui ; Zhuang, Xiaodong ; Guo, Yue ; Xiong, Zhenyu ; He, Lixiang ; Cai, Xiaojie ; Chen, Zhuohui ; Peng, Longyun ; Liao, Xinxue</creatorcontrib><description>Background
Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.
Methods
A total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age. The participants were grouped by obesity status (body mass index ≥30 kg/m
2
) and poor metabolic health (≥2 criteria for metabolic syndrome) into four metabolic phenotypes as follows: metabolically healthy non-obesity (MHN), MHO, metabolically unhealthy non-obesity (MUN), metabolically unhealthy obesity (MUO). The associations of the metabolic phenotypes (MHN serving as the reference) with left ventricular (LV) structure and function were evaluated using multiple linear regression models.
Results
At baseline, mean age was 25 years, 56.4% were women, and 44.7% were black. After a follow-up 25 years, MUN in young adulthood was associated with worse LV diastolic function (E/é ratio, β [95% CI], 0.73 [0.18, 1.28]), worse systolic function (global longitudinal strain [GLS], 0.60 [0.08, 1.12]) in comparison with MHN. MHO and MUO were associated with LV hypertrophy (LV mass index, 7.49 g/m
2
[4.63, 10.35]; 18.23 g/m
2
[12.47, 23.99], respectively), worse diastolic function (E/é ratio, 0.67 [0.31, 1.02]; 1.47 [0.79, 2.14], respectively), and worse systolic function (GLS, 0.72 [0.38, 1.06]; 1.35 [0.64, 2.05], respectively) in comparison with MHN. These results were consistent in several sensitivity analyses.
Conclusions
In this community-based cohort using data from the CARDIA study, obesity in young adulthood was significantly associated with LV hypertrophy, worse systolic and diastolic function regardless of metabolic status.
Relationship of Baseline Metabolic Phenotypes with Young Adulthood and Midlife Cardiac Structure and Function. Adjusted for year 0 covariates: age, sex, race, educational level, smoking status, drinking status, and physical activity; metabolically healthy non-obesity was used as a reference category for comparison.
†
Criteria for metabolic syndrome are listed in Supplementary Table
S6
. MUN metabolically unhealthy non-obesity, MHO metabolically healthy obesity, LVMi left ventricular mass index, LVEF left ventricular ejection fraction, E/A early to late peak diastolic mitral flow velocity ratio, E/é mitral inflow velocity to early diastolic mitral annular velocity, CI confidence interval.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-023-01288-3</identifier><identifier>PMID: 36899038</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699 ; Body Mass Index ; Body size ; Cardiovascular diseases ; Congestive heart failure ; Coronary artery ; Echocardiography ; Epidemiology ; Female ; Health Promotion and Disease Prevention ; Humans ; Hypertrophy ; Hypertrophy, Left Ventricular ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Metabolism ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity, Metabolically Benign ; Phenotype ; Phenotypes ; Public Health ; Regression analysis ; Regression models ; Risk Factors ; Sensitivity analysis ; Stroke Volume ; Structure-function relationships ; Ventricle ; Ventricular Function, Left ; Young adults</subject><ispartof>International Journal of Obesity, 2023-05, Vol.47 (5), p.399-405</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-7ac78050b843fe3c04a697649edab3b0803304c356306cd0d2ec1c8185c903b93</citedby><cites>FETCH-LOGICAL-c419t-7ac78050b843fe3c04a697649edab3b0803304c356306cd0d2ec1c8185c903b93</cites><orcidid>0000-0002-4770-318X ; 0000-0002-6077-0838</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-023-01288-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-023-01288-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36899038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Liu, Menghui</creatorcontrib><creatorcontrib>Zhuang, Xiaodong</creatorcontrib><creatorcontrib>Guo, Yue</creatorcontrib><creatorcontrib>Xiong, Zhenyu</creatorcontrib><creatorcontrib>He, Lixiang</creatorcontrib><creatorcontrib>Cai, Xiaojie</creatorcontrib><creatorcontrib>Chen, Zhuohui</creatorcontrib><creatorcontrib>Peng, Longyun</creatorcontrib><creatorcontrib>Liao, Xinxue</creatorcontrib><title>Association of metabolically healthy obesity in young adulthood with myocardial structure and function</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.
Methods
A total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age. The participants were grouped by obesity status (body mass index ≥30 kg/m
2
) and poor metabolic health (≥2 criteria for metabolic syndrome) into four metabolic phenotypes as follows: metabolically healthy non-obesity (MHN), MHO, metabolically unhealthy non-obesity (MUN), metabolically unhealthy obesity (MUO). The associations of the metabolic phenotypes (MHN serving as the reference) with left ventricular (LV) structure and function were evaluated using multiple linear regression models.
Results
At baseline, mean age was 25 years, 56.4% were women, and 44.7% were black. After a follow-up 25 years, MUN in young adulthood was associated with worse LV diastolic function (E/é ratio, β [95% CI], 0.73 [0.18, 1.28]), worse systolic function (global longitudinal strain [GLS], 0.60 [0.08, 1.12]) in comparison with MHN. MHO and MUO were associated with LV hypertrophy (LV mass index, 7.49 g/m
2
[4.63, 10.35]; 18.23 g/m
2
[12.47, 23.99], respectively), worse diastolic function (E/é ratio, 0.67 [0.31, 1.02]; 1.47 [0.79, 2.14], respectively), and worse systolic function (GLS, 0.72 [0.38, 1.06]; 1.35 [0.64, 2.05], respectively) in comparison with MHN. These results were consistent in several sensitivity analyses.
Conclusions
In this community-based cohort using data from the CARDIA study, obesity in young adulthood was significantly associated with LV hypertrophy, worse systolic and diastolic function regardless of metabolic status.
Relationship of Baseline Metabolic Phenotypes with Young Adulthood and Midlife Cardiac Structure and Function. Adjusted for year 0 covariates: age, sex, race, educational level, smoking status, drinking status, and physical activity; metabolically healthy non-obesity was used as a reference category for comparison.
†
Criteria for metabolic syndrome are listed in Supplementary Table
S6
. MUN metabolically unhealthy non-obesity, MHO metabolically healthy obesity, LVMi left ventricular mass index, LVEF left ventricular ejection fraction, E/A early to late peak diastolic mitral flow velocity ratio, E/é mitral inflow velocity to early diastolic mitral annular velocity, CI confidence interval.</description><subject>692/499</subject><subject>692/699</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Cardiovascular diseases</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Echocardiography</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Hypertrophy, Left Ventricular</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity, Metabolically Benign</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Public Health</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><subject>Stroke Volume</subject><subject>Structure-function relationships</subject><subject>Ventricle</subject><subject>Ventricular Function, Left</subject><subject>Young adults</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kTtvFTEQRi0URC4X_kCKyFIamoWxvX6VUcRLikQDteX1enMd7a6DH4r23-PLDSCloHIxZ8545kPogsB7Akx9yD1hQnRAWQeEKtWxF2hHeik63mt5hnbAQHbABT9Hr3O-BwDOgb5C50worZtih6brnKMLtoS44jjhxRc7xDk4O88bPng7l8OG4-BzKBsOK95iXe-wHWsrxDjix1AOeNmis2kMdsa5pOpKTR7bdcRTXd1R_Qa9nOyc_dund49-fPr4_eZLd_vt89eb69vO9USXTlonFXAYVM8mzxz0Vmgpeu1HO7ABFDAGvWNcMBBuhJF6R5wiiru2zqDZHr07eR9S_Fl9LmYJ2fl5tquPNRsqlQAtOIWGXj1D72NNa_udoQokZVLpI0VPlEsx5-Qn85DCYtNmCJhjCuaUgmkpmN8pGNaaLp_UdVj8-Lflz9kbwE5AbqX1zqd_s_-j_QXymJMx</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Wang, Peng</creator><creator>Liu, Menghui</creator><creator>Zhuang, Xiaodong</creator><creator>Guo, Yue</creator><creator>Xiong, Zhenyu</creator><creator>He, Lixiang</creator><creator>Cai, Xiaojie</creator><creator>Chen, Zhuohui</creator><creator>Peng, Longyun</creator><creator>Liao, Xinxue</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4770-318X</orcidid><orcidid>https://orcid.org/0000-0002-6077-0838</orcidid></search><sort><creationdate>20230501</creationdate><title>Association of metabolically healthy obesity in young adulthood with myocardial structure and function</title><author>Wang, Peng ; Liu, Menghui ; Zhuang, Xiaodong ; Guo, Yue ; Xiong, Zhenyu ; He, Lixiang ; Cai, Xiaojie ; Chen, Zhuohui ; Peng, Longyun ; Liao, Xinxue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-7ac78050b843fe3c04a697649edab3b0803304c356306cd0d2ec1c8185c903b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>692/499</topic><topic>692/699</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Cardiovascular diseases</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Echocardiography</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Hypertrophy, Left Ventricular</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Obesity, Metabolically Benign</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Public Health</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><topic>Stroke Volume</topic><topic>Structure-function relationships</topic><topic>Ventricle</topic><topic>Ventricular Function, Left</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Liu, Menghui</creatorcontrib><creatorcontrib>Zhuang, Xiaodong</creatorcontrib><creatorcontrib>Guo, Yue</creatorcontrib><creatorcontrib>Xiong, Zhenyu</creatorcontrib><creatorcontrib>He, Lixiang</creatorcontrib><creatorcontrib>Cai, Xiaojie</creatorcontrib><creatorcontrib>Chen, Zhuohui</creatorcontrib><creatorcontrib>Peng, Longyun</creatorcontrib><creatorcontrib>Liao, Xinxue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Peng</au><au>Liu, Menghui</au><au>Zhuang, Xiaodong</au><au>Guo, Yue</au><au>Xiong, Zhenyu</au><au>He, Lixiang</au><au>Cai, Xiaojie</au><au>Chen, Zhuohui</au><au>Peng, Longyun</au><au>Liao, Xinxue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of metabolically healthy obesity in young adulthood with myocardial structure and function</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>47</volume><issue>5</issue><spage>399</spage><epage>405</epage><pages>399-405</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background
Obesity is major cause of cardiovascular diseases. Metabolically healthy obesity (MHO) may increase heart failure risk early in life, and may be reflected in impaired cardiac structure and function. Therefore, we aimed to examine the relationship between MHO in young adulthood and cardiac structure and function.
Methods
A total of 3066 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included, who completed echocardiography in young adulthood and middle age. The participants were grouped by obesity status (body mass index ≥30 kg/m
2
) and poor metabolic health (≥2 criteria for metabolic syndrome) into four metabolic phenotypes as follows: metabolically healthy non-obesity (MHN), MHO, metabolically unhealthy non-obesity (MUN), metabolically unhealthy obesity (MUO). The associations of the metabolic phenotypes (MHN serving as the reference) with left ventricular (LV) structure and function were evaluated using multiple linear regression models.
Results
At baseline, mean age was 25 years, 56.4% were women, and 44.7% were black. After a follow-up 25 years, MUN in young adulthood was associated with worse LV diastolic function (E/é ratio, β [95% CI], 0.73 [0.18, 1.28]), worse systolic function (global longitudinal strain [GLS], 0.60 [0.08, 1.12]) in comparison with MHN. MHO and MUO were associated with LV hypertrophy (LV mass index, 7.49 g/m
2
[4.63, 10.35]; 18.23 g/m
2
[12.47, 23.99], respectively), worse diastolic function (E/é ratio, 0.67 [0.31, 1.02]; 1.47 [0.79, 2.14], respectively), and worse systolic function (GLS, 0.72 [0.38, 1.06]; 1.35 [0.64, 2.05], respectively) in comparison with MHN. These results were consistent in several sensitivity analyses.
Conclusions
In this community-based cohort using data from the CARDIA study, obesity in young adulthood was significantly associated with LV hypertrophy, worse systolic and diastolic function regardless of metabolic status.
Relationship of Baseline Metabolic Phenotypes with Young Adulthood and Midlife Cardiac Structure and Function. Adjusted for year 0 covariates: age, sex, race, educational level, smoking status, drinking status, and physical activity; metabolically healthy non-obesity was used as a reference category for comparison.
†
Criteria for metabolic syndrome are listed in Supplementary Table
S6
. MUN metabolically unhealthy non-obesity, MHO metabolically healthy obesity, LVMi left ventricular mass index, LVEF left ventricular ejection fraction, E/A early to late peak diastolic mitral flow velocity ratio, E/é mitral inflow velocity to early diastolic mitral annular velocity, CI confidence interval.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36899038</pmid><doi>10.1038/s41366-023-01288-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4770-318X</orcidid><orcidid>https://orcid.org/0000-0002-6077-0838</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2023-05, Vol.47 (5), p.399-405 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2786096520 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 692/499 692/699 Body Mass Index Body size Cardiovascular diseases Congestive heart failure Coronary artery Echocardiography Epidemiology Female Health Promotion and Disease Prevention Humans Hypertrophy Hypertrophy, Left Ventricular Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - epidemiology Metabolism Obesity Obesity - complications Obesity - epidemiology Obesity, Metabolically Benign Phenotype Phenotypes Public Health Regression analysis Regression models Risk Factors Sensitivity analysis Stroke Volume Structure-function relationships Ventricle Ventricular Function, Left Young adults |
| title | Association of metabolically healthy obesity in young adulthood with myocardial structure and function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T05%3A27%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20metabolically%20healthy%20obesity%20in%20young%20adulthood%20with%20myocardial%20structure%20and%20function&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Wang,%20Peng&rft.date=2023-05-01&rft.volume=47&rft.issue=5&rft.spage=399&rft.epage=405&rft.pages=399-405&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-023-01288-3&rft_dat=%3Cproquest_cross%3E2807237890%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2807237890&rft_id=info:pmid/36899038&rfr_iscdi=true |