Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes

Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and environmental interactions complicate the co...

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Veröffentlicht in:Journal of investigative dermatology 2023-08, Vol.143 (8), p.1520-1528.e5
Hauptverfasser: Smits, Jos P.H., van den Brink, Noa J.M., Meesters, Luca D., Hamdaoui, Hadia, Niehues, Hanna, Jansen, Patrick A.M., van Vlijmen-Willems, Ivonne M.J.J., Rodijk-Olthuis, Diana, Evrard, Céline, Poumay, Yves, van Geel, Michel, Hendriks, Wiljan J.A.J., Schalkwijk, Joost, Zeeuwen, Patrick L.J.M., van den Bogaard, Ellen H.
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Sprache:eng
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