Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type II Anti-CRISPR Proteins

[Display omitted] •There have been 38 type II anti-CRISPR proteins identified to date.•Anti-CRISPRs mainly inhibit one of the three main stages of Cas9 interference: sgRNA loading, target DNA binding, and DNA cleavage.•Type II anti-CRISPRs have incredibly diverse mechanisms of inhibition. Clustered...

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