α-Lipoic acid eliminates dioxin-induced offspring sexual immaturity by improving abnormalities in folic acid metabolism

[Display omitted] Maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes developmental and reproductive disorders in pups due to the attenuated luteinizing hormone (LH) production during the perinatal stage; however, the administration of α-lipoic acid (LA) to TCDD-exposed pregnant r...

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Veröffentlicht in:	Biochemical pharmacology 2023-04, Vol.210, p.115490-115490, Article 115490
Hauptverfasser:	Yuan, Ming, Sano, Hiroe, Nishino, Takaaki, Chen, Hongbin, Li, Ren-shi, Matsuo, Yuki, Nishida, Kyoko, Koga, Takayuki, Takeda, Tomoki, Tanaka, Yoshitaka, Ishii, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dioxin Dioxins - toxicity Female Folic acid metabolism Humans Male Maternal Exposure - adverse effects Polychlorinated Dibenzodioxins - toxicity Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - prevention & control Rats Reproduction Reproductive toxicity Thioctic Acid - adverse effects α-Lipoic acid
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