Comparing the incubation period, serial interval, and infectiousness profile between SARS‐CoV‐2 Omicron and Delta variants
In January 2022, the SARS‐CoV‐2 Omicron variants initiated major outbreaks and dominated the transmissions in Hong Kong, displacing an earlier outbreak seeded by the Delta variants. To provide insight into the transmission potential of the emerging variants, we aimed to compare the epidemiological c...
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| Veröffentlicht in: | Journal of medical virology 2023-03, Vol.95 (3), p.e28648-n/a |
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| creator | Guo, Zihao Zhao, Shi Mok, Chris Ka Pun So, Ray T. Y. Yam, Carrie Ho Kwan Chow, Tsz Yu Chan, Tony Chin Pok Wei, Yuchen Jia, Katherine Min Wang, Maggie Haitian Chong, Ka Chun Yeoh, Eng Kiong |
| description | In January 2022, the SARS‐CoV‐2 Omicron variants initiated major outbreaks and dominated the transmissions in Hong Kong, displacing an earlier outbreak seeded by the Delta variants. To provide insight into the transmission potential of the emerging variants, we aimed to compare the epidemiological characteristics of the Omicron and Delta variants. We analyzed the line‐list clinical and contact tracing data of the SARS‐CoV‐2 confirmed cases in Hong Kong. Transmission pairs were constructed based on the individual contact history. We fitted bias‐controlled models to the data to estimate the serial interval, incubation period and infectiousness profile of the two variants. Viral load data were extracted and fitted to the random effect models to investigate the potential risk modifiers for the clinical viral shedding course. Totally 14 401 confirmed cases were reported between January 1 and February 15, 2022. The estimated mean serial interval (4.4 days vs. 5.8 days) and incubation period (3.4 days vs. 3.8 days) were shorter for the Omicron than the Delta variants. A larger proportion of presymptomatic transmission was observed for the Omicron (62%) compared to the Delta variants (48%). The Omicron cases had higher mean viral load over an infection course than the Delta cases, with the elder cases appearing more infectious than the younger cases for both variants. The epidemiological features of Omicron variants were likely an obstacle to contact tracing measures, imposed as a major intervention in settings like Hong Kong. Continuously monitoring the epidemiological feature for any emerging SARS‐CoV‐2 variants in the future is needed to assist officials in planning measures for COVID‐19 control. |
| doi_str_mv | 10.1002/jmv.28648 |
| format | Article |
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Y. ; Yam, Carrie Ho Kwan ; Chow, Tsz Yu ; Chan, Tony Chin Pok ; Wei, Yuchen ; Jia, Katherine Min ; Wang, Maggie Haitian ; Chong, Ka Chun ; Yeoh, Eng Kiong</creator><creatorcontrib>Guo, Zihao ; Zhao, Shi ; Mok, Chris Ka Pun ; So, Ray T. Y. ; Yam, Carrie Ho Kwan ; Chow, Tsz Yu ; Chan, Tony Chin Pok ; Wei, Yuchen ; Jia, Katherine Min ; Wang, Maggie Haitian ; Chong, Ka Chun ; Yeoh, Eng Kiong</creatorcontrib><description>In January 2022, the SARS‐CoV‐2 Omicron variants initiated major outbreaks and dominated the transmissions in Hong Kong, displacing an earlier outbreak seeded by the Delta variants. To provide insight into the transmission potential of the emerging variants, we aimed to compare the epidemiological characteristics of the Omicron and Delta variants. We analyzed the line‐list clinical and contact tracing data of the SARS‐CoV‐2 confirmed cases in Hong Kong. Transmission pairs were constructed based on the individual contact history. We fitted bias‐controlled models to the data to estimate the serial interval, incubation period and infectiousness profile of the two variants. Viral load data were extracted and fitted to the random effect models to investigate the potential risk modifiers for the clinical viral shedding course. Totally 14 401 confirmed cases were reported between January 1 and February 15, 2022. The estimated mean serial interval (4.4 days vs. 5.8 days) and incubation period (3.4 days vs. 3.8 days) were shorter for the Omicron than the Delta variants. A larger proportion of presymptomatic transmission was observed for the Omicron (62%) compared to the Delta variants (48%). The Omicron cases had higher mean viral load over an infection course than the Delta cases, with the elder cases appearing more infectious than the younger cases for both variants. The epidemiological features of Omicron variants were likely an obstacle to contact tracing measures, imposed as a major intervention in settings like Hong Kong. Continuously monitoring the epidemiological feature for any emerging SARS‐CoV‐2 variants in the future is needed to assist officials in planning measures for COVID‐19 control.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.28648</identifier><identifier>PMID: 36892159</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Contact tracing ; COVID-19 ; COVID-19 - epidemiology ; Disease Outbreaks ; Epidemiology ; Humans ; incubation period ; Infectious Disease Incubation Period ; Omicron variants ; Outbreaks ; presymptomatic transmission ; SARS-CoV-2 - genetics ; SARS‐CoV‐2 ; Seizures ; serial interval ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Viral diseases ; viral shedding ; Virology</subject><ispartof>Journal of medical virology, 2023-03, Vol.95 (3), p.e28648-n/a</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-eed13a58911e8e6bb0d692d4eaf527d35844c7bc035e00af3a52af6111cee4733</citedby><cites>FETCH-LOGICAL-c3888-eed13a58911e8e6bb0d692d4eaf527d35844c7bc035e00af3a52af6111cee4733</cites><orcidid>0000-0001-5610-1298</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.28648$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.28648$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36892159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Zihao</creatorcontrib><creatorcontrib>Zhao, Shi</creatorcontrib><creatorcontrib>Mok, Chris Ka Pun</creatorcontrib><creatorcontrib>So, Ray T. Y.</creatorcontrib><creatorcontrib>Yam, Carrie Ho Kwan</creatorcontrib><creatorcontrib>Chow, Tsz Yu</creatorcontrib><creatorcontrib>Chan, Tony Chin Pok</creatorcontrib><creatorcontrib>Wei, Yuchen</creatorcontrib><creatorcontrib>Jia, Katherine Min</creatorcontrib><creatorcontrib>Wang, Maggie Haitian</creatorcontrib><creatorcontrib>Chong, Ka Chun</creatorcontrib><creatorcontrib>Yeoh, Eng Kiong</creatorcontrib><title>Comparing the incubation period, serial interval, and infectiousness profile between SARS‐CoV‐2 Omicron and Delta variants</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>In January 2022, the SARS‐CoV‐2 Omicron variants initiated major outbreaks and dominated the transmissions in Hong Kong, displacing an earlier outbreak seeded by the Delta variants. To provide insight into the transmission potential of the emerging variants, we aimed to compare the epidemiological characteristics of the Omicron and Delta variants. We analyzed the line‐list clinical and contact tracing data of the SARS‐CoV‐2 confirmed cases in Hong Kong. Transmission pairs were constructed based on the individual contact history. We fitted bias‐controlled models to the data to estimate the serial interval, incubation period and infectiousness profile of the two variants. Viral load data were extracted and fitted to the random effect models to investigate the potential risk modifiers for the clinical viral shedding course. Totally 14 401 confirmed cases were reported between January 1 and February 15, 2022. The estimated mean serial interval (4.4 days vs. 5.8 days) and incubation period (3.4 days vs. 3.8 days) were shorter for the Omicron than the Delta variants. A larger proportion of presymptomatic transmission was observed for the Omicron (62%) compared to the Delta variants (48%). The Omicron cases had higher mean viral load over an infection course than the Delta cases, with the elder cases appearing more infectious than the younger cases for both variants. The epidemiological features of Omicron variants were likely an obstacle to contact tracing measures, imposed as a major intervention in settings like Hong Kong. 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Y.</au><au>Yam, Carrie Ho Kwan</au><au>Chow, Tsz Yu</au><au>Chan, Tony Chin Pok</au><au>Wei, Yuchen</au><au>Jia, Katherine Min</au><au>Wang, Maggie Haitian</au><au>Chong, Ka Chun</au><au>Yeoh, Eng Kiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing the incubation period, serial interval, and infectiousness profile between SARS‐CoV‐2 Omicron and Delta variants</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2023-03</date><risdate>2023</risdate><volume>95</volume><issue>3</issue><spage>e28648</spage><epage>n/a</epage><pages>e28648-n/a</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>In January 2022, the SARS‐CoV‐2 Omicron variants initiated major outbreaks and dominated the transmissions in Hong Kong, displacing an earlier outbreak seeded by the Delta variants. To provide insight into the transmission potential of the emerging variants, we aimed to compare the epidemiological characteristics of the Omicron and Delta variants. We analyzed the line‐list clinical and contact tracing data of the SARS‐CoV‐2 confirmed cases in Hong Kong. Transmission pairs were constructed based on the individual contact history. We fitted bias‐controlled models to the data to estimate the serial interval, incubation period and infectiousness profile of the two variants. Viral load data were extracted and fitted to the random effect models to investigate the potential risk modifiers for the clinical viral shedding course. Totally 14 401 confirmed cases were reported between January 1 and February 15, 2022. The estimated mean serial interval (4.4 days vs. 5.8 days) and incubation period (3.4 days vs. 3.8 days) were shorter for the Omicron than the Delta variants. A larger proportion of presymptomatic transmission was observed for the Omicron (62%) compared to the Delta variants (48%). The Omicron cases had higher mean viral load over an infection course than the Delta cases, with the elder cases appearing more infectious than the younger cases for both variants. The epidemiological features of Omicron variants were likely an obstacle to contact tracing measures, imposed as a major intervention in settings like Hong Kong. Continuously monitoring the epidemiological feature for any emerging SARS‐CoV‐2 variants in the future is needed to assist officials in planning measures for COVID‐19 control.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36892159</pmid><doi>10.1002/jmv.28648</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5610-1298</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Contact tracing COVID-19 COVID-19 - epidemiology Disease Outbreaks Epidemiology Humans incubation period Infectious Disease Incubation Period Omicron variants Outbreaks presymptomatic transmission SARS-CoV-2 - genetics SARS‐CoV‐2 Seizures serial interval Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases viral shedding Virology |
| title | Comparing the incubation period, serial interval, and infectiousness profile between SARS‐CoV‐2 Omicron and Delta variants |
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