The global burden of metabolic disease: Data from 2000 to 2019
Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabo...
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| Veröffentlicht in: | Cell metabolism 2023-03, Vol.35 (3), p.414-428.e3 |
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| creator | Chew, Nicholas W.S. Ng, Cheng Han Tan, Darren Jun Hao Kong, Gwyneth Lin, Chaoxing Chin, Yip Han Lim, Wen Hui Huang, Daniel Q. Quek, Jingxuan Fu, Clarissa Elysia Xiao, Jieling Syn, Nicholas Foo, Roger Khoo, Chin Meng Wang, Jiong-Wei Dimitriadis, Georgios K. Young, Dan Yock Siddiqui, Mohammad Shadab Lam, Carolyn S.P. Wang, Yibin Figtree, Gemma A. Chan, Mark Y. Cummings, David E. Noureddin, Mazen Wong, Vincent Wai-Sun Ma, Ronald Ching Wan Mantzoros, Christos S. Sanyal, Arun Muthiah, Mark Dhinesh |
| description | Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabolic risk factors (hyperlipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio-demographic index (SDI) countries. Mortality rates decreased over time in hyperlipidemia, hypertension, and NAFLD, but not in T2DM and obesity. The highest mortality was found in the World Health Organization Eastern Mediterranean region, and low to low-middle SDI countries. The global prevalence of metabolic diseases has risen over the past two decades regardless of SDI. Urgent attention is needed to address the unchanging mortality rates attributed to metabolic disease and the entrenched sex-regional-socioeconomic disparities in mortality.
[Display omitted]
•Global estimates from the GBD Study 2019 were examined for metabolic diseases•Mortality rates decreased over time for hyperlipidemia, hypertension, and NAFLD•Mortality rates remained unchanged over time for diabetes and obesity•The highest mortality was in the Eastern Mediterranean and low-income countries
Global estimates from the GBD Study 2019 reveal decreasing mortality rates between 2000 and 2019 for hyperlipidemia, hypertension, and NAFLD, but not for T2DM and obesity. The highest mortality rate due to metabolic disease was found in the Eastern Mediterranean, and in low- to low-middle-income countries. Urgent attention is needed to address high and unchanging mortality rates as well as entrenched sex-regional-socioeconomic disparities in death related to metabolic disease. |
| doi_str_mv | 10.1016/j.cmet.2023.02.003 |
| format | Article |
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[Display omitted]
•Global estimates from the GBD Study 2019 were examined for metabolic diseases•Mortality rates decreased over time for hyperlipidemia, hypertension, and NAFLD•Mortality rates remained unchanged over time for diabetes and obesity•The highest mortality was in the Eastern Mediterranean and low-income countries
Global estimates from the GBD Study 2019 reveal decreasing mortality rates between 2000 and 2019 for hyperlipidemia, hypertension, and NAFLD, but not for T2DM and obesity. The highest mortality rate due to metabolic disease was found in the Eastern Mediterranean, and in low- to low-middle-income countries. Urgent attention is needed to address high and unchanging mortality rates as well as entrenched sex-regional-socioeconomic disparities in death related to metabolic disease.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2023.02.003</identifier><identifier>PMID: 36889281</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; disability-adjusted life years ; disparity ; global burden ; Global Burden of Disease ; Humans ; Hypertension ; metabolic disease ; Metabolic Diseases - epidemiology ; mortality ; Non-alcoholic Fatty Liver Disease ; obesity ; Obesity - epidemiology ; Quality-Adjusted Life Years ; Risk Factors</subject><ispartof>Cell metabolism, 2023-03, Vol.35 (3), p.414-428.e3</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-c68c728a6a4ec0cefe8ce73d58a130b13bd93820259334c18ca2048d61cfc47f3</citedby><cites>FETCH-LOGICAL-c400t-c68c728a6a4ec0cefe8ce73d58a130b13bd93820259334c18ca2048d61cfc47f3</cites><orcidid>0000-0002-8297-1569</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1550413123000396$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36889281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chew, Nicholas W.S.</creatorcontrib><creatorcontrib>Ng, Cheng Han</creatorcontrib><creatorcontrib>Tan, Darren Jun Hao</creatorcontrib><creatorcontrib>Kong, Gwyneth</creatorcontrib><creatorcontrib>Lin, Chaoxing</creatorcontrib><creatorcontrib>Chin, Yip Han</creatorcontrib><creatorcontrib>Lim, Wen Hui</creatorcontrib><creatorcontrib>Huang, Daniel Q.</creatorcontrib><creatorcontrib>Quek, Jingxuan</creatorcontrib><creatorcontrib>Fu, Clarissa Elysia</creatorcontrib><creatorcontrib>Xiao, Jieling</creatorcontrib><creatorcontrib>Syn, Nicholas</creatorcontrib><creatorcontrib>Foo, Roger</creatorcontrib><creatorcontrib>Khoo, Chin Meng</creatorcontrib><creatorcontrib>Wang, Jiong-Wei</creatorcontrib><creatorcontrib>Dimitriadis, Georgios K.</creatorcontrib><creatorcontrib>Young, Dan Yock</creatorcontrib><creatorcontrib>Siddiqui, Mohammad Shadab</creatorcontrib><creatorcontrib>Lam, Carolyn S.P.</creatorcontrib><creatorcontrib>Wang, Yibin</creatorcontrib><creatorcontrib>Figtree, Gemma A.</creatorcontrib><creatorcontrib>Chan, Mark Y.</creatorcontrib><creatorcontrib>Cummings, David E.</creatorcontrib><creatorcontrib>Noureddin, Mazen</creatorcontrib><creatorcontrib>Wong, Vincent Wai-Sun</creatorcontrib><creatorcontrib>Ma, Ronald Ching Wan</creatorcontrib><creatorcontrib>Mantzoros, Christos S.</creatorcontrib><creatorcontrib>Sanyal, Arun</creatorcontrib><creatorcontrib>Muthiah, Mark Dhinesh</creatorcontrib><title>The global burden of metabolic disease: Data from 2000 to 2019</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabolic risk factors (hyperlipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio-demographic index (SDI) countries. Mortality rates decreased over time in hyperlipidemia, hypertension, and NAFLD, but not in T2DM and obesity. The highest mortality was found in the World Health Organization Eastern Mediterranean region, and low to low-middle SDI countries. The global prevalence of metabolic diseases has risen over the past two decades regardless of SDI. Urgent attention is needed to address the unchanging mortality rates attributed to metabolic disease and the entrenched sex-regional-socioeconomic disparities in mortality.
[Display omitted]
•Global estimates from the GBD Study 2019 were examined for metabolic diseases•Mortality rates decreased over time for hyperlipidemia, hypertension, and NAFLD•Mortality rates remained unchanged over time for diabetes and obesity•The highest mortality was in the Eastern Mediterranean and low-income countries
Global estimates from the GBD Study 2019 reveal decreasing mortality rates between 2000 and 2019 for hyperlipidemia, hypertension, and NAFLD, but not for T2DM and obesity. The highest mortality rate due to metabolic disease was found in the Eastern Mediterranean, and in low- to low-middle-income countries. Urgent attention is needed to address high and unchanging mortality rates as well as entrenched sex-regional-socioeconomic disparities in death related to metabolic disease.</description><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>disability-adjusted life years</subject><subject>disparity</subject><subject>global burden</subject><subject>Global Burden of Disease</subject><subject>Humans</subject><subject>Hypertension</subject><subject>metabolic disease</subject><subject>Metabolic Diseases - epidemiology</subject><subject>mortality</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>obesity</subject><subject>Obesity - epidemiology</subject><subject>Quality-Adjusted Life Years</subject><subject>Risk Factors</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAyyQl2wSxnYeDkJIqDylSmzK2nImE0iV1MVOkfh7XBVYsrqzOPdKcxg7E5AKEMXlMsWBxlSCVCnIFEDtsamolEzKTMJ-vPMckkwoMWFHISwjUKhKHbKJKrSupBZTdrN4J_7Wu9r2vN74hlbctTzO2tr1HfKmC2QDXfE7O1reejdwCQB8dDFFdcIOWtsHOv3JY_b6cL-YPSXzl8fn2e08wQxgTLDQWEptC5sRAlJLGqlUTa6tUFALVTeV0vGRvFIqQ6HRSsh0UwhsMStbdcwudrtr7z42FEYzdAGp7-2K3CYYWepcVEUliojKHYreheCpNWvfDdZ_GQFm680szdab2XozIE3UEkvnP_ubeqDmr_IrKgLXO4Dil58deROwoxVS03nC0TSu-2__G5jEe08</recordid><startdate>20230307</startdate><enddate>20230307</enddate><creator>Chew, Nicholas W.S.</creator><creator>Ng, Cheng Han</creator><creator>Tan, Darren Jun Hao</creator><creator>Kong, Gwyneth</creator><creator>Lin, Chaoxing</creator><creator>Chin, Yip Han</creator><creator>Lim, Wen Hui</creator><creator>Huang, Daniel Q.</creator><creator>Quek, Jingxuan</creator><creator>Fu, Clarissa Elysia</creator><creator>Xiao, Jieling</creator><creator>Syn, Nicholas</creator><creator>Foo, Roger</creator><creator>Khoo, Chin Meng</creator><creator>Wang, Jiong-Wei</creator><creator>Dimitriadis, Georgios K.</creator><creator>Young, Dan Yock</creator><creator>Siddiqui, Mohammad Shadab</creator><creator>Lam, Carolyn S.P.</creator><creator>Wang, Yibin</creator><creator>Figtree, Gemma A.</creator><creator>Chan, Mark Y.</creator><creator>Cummings, David E.</creator><creator>Noureddin, Mazen</creator><creator>Wong, Vincent Wai-Sun</creator><creator>Ma, Ronald Ching Wan</creator><creator>Mantzoros, Christos S.</creator><creator>Sanyal, Arun</creator><creator>Muthiah, Mark Dhinesh</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8297-1569</orcidid></search><sort><creationdate>20230307</creationdate><title>The global burden of metabolic disease: Data from 2000 to 2019</title><author>Chew, Nicholas W.S. ; 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For metabolic risk factors (hyperlipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio-demographic index (SDI) countries. Mortality rates decreased over time in hyperlipidemia, hypertension, and NAFLD, but not in T2DM and obesity. The highest mortality was found in the World Health Organization Eastern Mediterranean region, and low to low-middle SDI countries. The global prevalence of metabolic diseases has risen over the past two decades regardless of SDI. Urgent attention is needed to address the unchanging mortality rates attributed to metabolic disease and the entrenched sex-regional-socioeconomic disparities in mortality.
[Display omitted]
•Global estimates from the GBD Study 2019 were examined for metabolic diseases•Mortality rates decreased over time for hyperlipidemia, hypertension, and NAFLD•Mortality rates remained unchanged over time for diabetes and obesity•The highest mortality was in the Eastern Mediterranean and low-income countries
Global estimates from the GBD Study 2019 reveal decreasing mortality rates between 2000 and 2019 for hyperlipidemia, hypertension, and NAFLD, but not for T2DM and obesity. The highest mortality rate due to metabolic disease was found in the Eastern Mediterranean, and in low- to low-middle-income countries. Urgent attention is needed to address high and unchanging mortality rates as well as entrenched sex-regional-socioeconomic disparities in death related to metabolic disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36889281</pmid><doi>10.1016/j.cmet.2023.02.003</doi><orcidid>https://orcid.org/0000-0002-8297-1569</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell metabolism, 2023-03, Vol.35 (3), p.414-428.e3 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology disability-adjusted life years disparity global burden Global Burden of Disease Humans Hypertension metabolic disease Metabolic Diseases - epidemiology mortality Non-alcoholic Fatty Liver Disease obesity Obesity - epidemiology Quality-Adjusted Life Years Risk Factors |
| title | The global burden of metabolic disease: Data from 2000 to 2019 |
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