Adenosine A2A receptor activation reduces chondrocyte senescence

Osteoarthritis (OA) pathogenesis is associated with reduced chondrocyte homeostasis and increased levels of cartilage cellular senescence. Chondrosenescence is the development of cartilage senescence that increases with aging joints and disrupts chondrocyte homeostasis and is associated with OA. Ade...

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Veröffentlicht in:	The FASEB journal 2023-04, Vol.37 (4), p.e22838-n/a
Hauptverfasser:	Friedman, Benjamin, Larranaga‐Vera, Ane, Castro, Cristina M., Corciulo, Carmen, Rabbani, Piul, Cronstein, Bruce N.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine adenosine A2A receptor aging AMP-Activated Protein Kinases - metabolism Animals cartilage Cartilage, Articular - metabolism Cellular Senescence - physiology chondrocytes Chondrocytes - metabolism Humans Mice osteoarthritis Osteoarthritis - metabolism p53 variants Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism senescence Sirtuin 1 - metabolism Tumor Suppressor Protein p53 - metabolism
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