Acidotic and hypoxic tumor microenvironment induces changes to histone acetylation and methylation in oral squamous cell carcinoma

Hypoxia and acidosis are ubiquitous hallmarks of the tumor microenvironment (TME), and in most solid cancers they have been linked to rewired cancer cell metabolism. These TME stresses are linked to changes in histone post‐translational modifications (PTMs) such as methylation and acetylation, which...

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Veröffentlicht in:	Biomedical chromatography 2023-06, Vol.37 (6), p.e5616-n/a
Hauptverfasser:	Khan, Tajwali, Iftikhar, Fizza, Akhlaq, Rafia, Musharraf, Syed Ghulam, Ali, Arslan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acidosis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Head and Neck Neoplasms histone acetylation Histones - genetics Histones - metabolism Humans hypoxia Methylation Mouth Neoplasms - metabolism Mouth Neoplasms - pathology oral squamous cell carcinoma Protein Processing, Post-Translational proteomics Squamous Cell Carcinoma of Head and Neck Tumor Microenvironment
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