The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis
Background To investigate the association between keratoconus (KC) and allergic eye diseases, eye rubbing, and atopy. Methods PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies investigating eye allergy, atopy, and eye rubbing as risk factors for KC up to April 2021. Tw...
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| Veröffentlicht in: | Clinical & experimental ophthalmology 2023-05, Vol.51 (4), p.O1-O16 |
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| creator | Seth, Ishith Bulloch, Gabriella Vine, Michael Outmezguine, Joseph Seth, Nimish Every, James Daniell, Mark |
| description | Background
To investigate the association between keratoconus (KC) and allergic eye diseases, eye rubbing, and atopy.
Methods
PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies investigating eye allergy, atopy, and eye rubbing as risk factors for KC up to April 2021. Two authors independently screened all titles and s against the predefined inclusion and exclusion criteria. The study analysed the prevalence of KC and its risk factors, including eye rubbing, family history of KC, atopy, and allergic eye diseases. The National Institutes of Health Study Quality Assessment Tool was used. Pooled data are presented as odds ratios (OR) and 95% confidence intervals (CI). The analysis was conducted using RevMan version 5.4 software.
Results
The initial search yielded 573 articles. After screening, 21 studies were identified for qualitative analysis and 15 for quantitative synthesis. A significant association was found between KC and eye rubbing (OR = 5.22, 95% CI [2.80, 9.75], p |
| doi_str_mv | 10.1111/ceo.14215 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2784835857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2825478920</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-945e47ad9582ec5f0df68631c453cee3b5da17eb6c7b23ab2c9d5185cccf63003</originalsourceid><addsrcrecordid>eNp1kDtOxDAQQC0E4l9wAWSJBooFfxOHbrXiJyHRQB05zgQMSQyehFU6jsAZOQmBXSiQcDMu3jyNHiF7nB3z8Z04CMdcCa5XyCZXSkwylvLV5T9RTG2QLcRHxpgWMlknGzIxRgjGNkl1-wDUIgbnbedDSwvo5gAtfYJou-BC2yO1bUltXUO8947CALT0CBYBT-mU4oAdNOOyoxFePcy_8QY6-_H2bltbD-hxh6xVtkbYXc5tcnd-dju7nFzfXFzNptcTJ7XUk0xpUKktM20EOF2xskpMIrlTWjoAWejS8hSKxKWFkLYQLis1N9o5VyWSMblNDhfe5xheesAubzw6qGvbQugxF6lRRmqj0xE9-IM-hj6O946UEVqlJhNfwqMF5WJAjFDlz9E3Ng45Z_lX_HyMn3_HH9n9pbEvGih_yZ_aI3CyAOa-huF_Uz47u1koPwGFGo9j</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2825478920</pqid></control><display><type>article</type><title>The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Seth, Ishith ; Bulloch, Gabriella ; Vine, Michael ; Outmezguine, Joseph ; Seth, Nimish ; Every, James ; Daniell, Mark</creator><creatorcontrib>Seth, Ishith ; Bulloch, Gabriella ; Vine, Michael ; Outmezguine, Joseph ; Seth, Nimish ; Every, James ; Daniell, Mark</creatorcontrib><description>Background
To investigate the association between keratoconus (KC) and allergic eye diseases, eye rubbing, and atopy.
Methods
PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies investigating eye allergy, atopy, and eye rubbing as risk factors for KC up to April 2021. Two authors independently screened all titles and s against the predefined inclusion and exclusion criteria. The study analysed the prevalence of KC and its risk factors, including eye rubbing, family history of KC, atopy, and allergic eye diseases. The National Institutes of Health Study Quality Assessment Tool was used. Pooled data are presented as odds ratios (OR) and 95% confidence intervals (CI). The analysis was conducted using RevMan version 5.4 software.
Results
The initial search yielded 573 articles. After screening, 21 studies were identified for qualitative analysis and 15 for quantitative synthesis. A significant association was found between KC and eye rubbing (OR = 5.22, 95% CI [2.80, 9.75], p < 0.00001), family history of KC (OR = 6.67, 95% CI [4.77, 9.33], p < 0.00001), and allergies (OR = 2.21, 95% CI [1.57, 3.13], p < 0.00001). However, no significant association was found between KC and allergic eye disease (OR = 1.82, 95% CI [0.37, 8.97], p = 0.46), atopy (OR = 1.54, 95% CI [0.58, 4.09], p = 0.39), allergic rhinitis (OR = 0.85, 95% CI [0.54, 1.33], p = 0.47), smoking (OR = 0.96, 95% CI [0.76, 1.21], p = 0.73), and asthma (OR = 1.58, 95% CI [0.99, 2.53], p = 0.05).
Conclusion
Significant associations were observed between KC and eye rubbing, family history, and allergy, but not with allergic eye disease, atopy, asthma, and allergic rhinitis.
This article can be found online at https://onlinelibrary.wiley.com/doi/10.1111/ceo.14215</description><identifier>ISSN: 1442-6404</identifier><identifier>EISSN: 1442-9071</identifier><identifier>DOI: 10.1111/ceo.14215</identifier><identifier>PMID: 36882200</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Allergic rhinitis ; Allergies ; allergy ; Asthma ; Asthma - complications ; Asthma - epidemiology ; Atopy ; Eye diseases ; eye rubbing ; Family medical history ; Hay fever ; Humans ; Hypersensitivity ; Keratoconus ; Keratoconus - diagnosis ; Keratoconus - epidemiology ; Keratoconus - etiology ; Meta-analysis ; Odds Ratio ; Quality control ; Rhinitis ; Rhinitis, Allergic - complications ; Rhinitis, Allergic - epidemiology ; Risk Factors ; vernal conjunctivitis</subject><ispartof>Clinical & experimental ophthalmology, 2023-05, Vol.51 (4), p.O1-O16</ispartof><rights>2023 Royal Australian and New Zealand College of Ophthalmologists.</rights><rights>2023 Royal Australian and New Zealand College of Ophthalmologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-945e47ad9582ec5f0df68631c453cee3b5da17eb6c7b23ab2c9d5185cccf63003</citedby><cites>FETCH-LOGICAL-c3535-945e47ad9582ec5f0df68631c453cee3b5da17eb6c7b23ab2c9d5185cccf63003</cites><orcidid>0000-0001-5444-8925 ; 0000-0001-9528-7005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fceo.14215$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fceo.14215$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36882200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seth, Ishith</creatorcontrib><creatorcontrib>Bulloch, Gabriella</creatorcontrib><creatorcontrib>Vine, Michael</creatorcontrib><creatorcontrib>Outmezguine, Joseph</creatorcontrib><creatorcontrib>Seth, Nimish</creatorcontrib><creatorcontrib>Every, James</creatorcontrib><creatorcontrib>Daniell, Mark</creatorcontrib><title>The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis</title><title>Clinical & experimental ophthalmology</title><addtitle>Clin Exp Ophthalmol</addtitle><description>Background
To investigate the association between keratoconus (KC) and allergic eye diseases, eye rubbing, and atopy.
Methods
PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies investigating eye allergy, atopy, and eye rubbing as risk factors for KC up to April 2021. Two authors independently screened all titles and s against the predefined inclusion and exclusion criteria. The study analysed the prevalence of KC and its risk factors, including eye rubbing, family history of KC, atopy, and allergic eye diseases. The National Institutes of Health Study Quality Assessment Tool was used. Pooled data are presented as odds ratios (OR) and 95% confidence intervals (CI). The analysis was conducted using RevMan version 5.4 software.
Results
The initial search yielded 573 articles. After screening, 21 studies were identified for qualitative analysis and 15 for quantitative synthesis. A significant association was found between KC and eye rubbing (OR = 5.22, 95% CI [2.80, 9.75], p < 0.00001), family history of KC (OR = 6.67, 95% CI [4.77, 9.33], p < 0.00001), and allergies (OR = 2.21, 95% CI [1.57, 3.13], p < 0.00001). However, no significant association was found between KC and allergic eye disease (OR = 1.82, 95% CI [0.37, 8.97], p = 0.46), atopy (OR = 1.54, 95% CI [0.58, 4.09], p = 0.39), allergic rhinitis (OR = 0.85, 95% CI [0.54, 1.33], p = 0.47), smoking (OR = 0.96, 95% CI [0.76, 1.21], p = 0.73), and asthma (OR = 1.58, 95% CI [0.99, 2.53], p = 0.05).
Conclusion
Significant associations were observed between KC and eye rubbing, family history, and allergy, but not with allergic eye disease, atopy, asthma, and allergic rhinitis.
This article can be found online at https://onlinelibrary.wiley.com/doi/10.1111/ceo.14215</description><subject>Allergic rhinitis</subject><subject>Allergies</subject><subject>allergy</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - epidemiology</subject><subject>Atopy</subject><subject>Eye diseases</subject><subject>eye rubbing</subject><subject>Family medical history</subject><subject>Hay fever</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Keratoconus</subject><subject>Keratoconus - diagnosis</subject><subject>Keratoconus - epidemiology</subject><subject>Keratoconus - etiology</subject><subject>Meta-analysis</subject><subject>Odds Ratio</subject><subject>Quality control</subject><subject>Rhinitis</subject><subject>Rhinitis, Allergic - complications</subject><subject>Rhinitis, Allergic - epidemiology</subject><subject>Risk Factors</subject><subject>vernal conjunctivitis</subject><issn>1442-6404</issn><issn>1442-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtOxDAQQC0E4l9wAWSJBooFfxOHbrXiJyHRQB05zgQMSQyehFU6jsAZOQmBXSiQcDMu3jyNHiF7nB3z8Z04CMdcCa5XyCZXSkwylvLV5T9RTG2QLcRHxpgWMlknGzIxRgjGNkl1-wDUIgbnbedDSwvo5gAtfYJou-BC2yO1bUltXUO8947CALT0CBYBT-mU4oAdNOOyoxFePcy_8QY6-_H2bltbD-hxh6xVtkbYXc5tcnd-dju7nFzfXFzNptcTJ7XUk0xpUKktM20EOF2xskpMIrlTWjoAWejS8hSKxKWFkLYQLis1N9o5VyWSMblNDhfe5xheesAubzw6qGvbQugxF6lRRmqj0xE9-IM-hj6O946UEVqlJhNfwqMF5WJAjFDlz9E3Ng45Z_lX_HyMn3_HH9n9pbEvGih_yZ_aI3CyAOa-huF_Uz47u1koPwGFGo9j</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Seth, Ishith</creator><creator>Bulloch, Gabriella</creator><creator>Vine, Michael</creator><creator>Outmezguine, Joseph</creator><creator>Seth, Nimish</creator><creator>Every, James</creator><creator>Daniell, Mark</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5444-8925</orcidid><orcidid>https://orcid.org/0000-0001-9528-7005</orcidid></search><sort><creationdate>202305</creationdate><title>The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis</title><author>Seth, Ishith ; Bulloch, Gabriella ; Vine, Michael ; Outmezguine, Joseph ; Seth, Nimish ; Every, James ; Daniell, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-945e47ad9582ec5f0df68631c453cee3b5da17eb6c7b23ab2c9d5185cccf63003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergic rhinitis</topic><topic>Allergies</topic><topic>allergy</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - epidemiology</topic><topic>Atopy</topic><topic>Eye diseases</topic><topic>eye rubbing</topic><topic>Family medical history</topic><topic>Hay fever</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Keratoconus</topic><topic>Keratoconus - diagnosis</topic><topic>Keratoconus - epidemiology</topic><topic>Keratoconus - etiology</topic><topic>Meta-analysis</topic><topic>Odds Ratio</topic><topic>Quality control</topic><topic>Rhinitis</topic><topic>Rhinitis, Allergic - complications</topic><topic>Rhinitis, Allergic - epidemiology</topic><topic>Risk Factors</topic><topic>vernal conjunctivitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seth, Ishith</creatorcontrib><creatorcontrib>Bulloch, Gabriella</creatorcontrib><creatorcontrib>Vine, Michael</creatorcontrib><creatorcontrib>Outmezguine, Joseph</creatorcontrib><creatorcontrib>Seth, Nimish</creatorcontrib><creatorcontrib>Every, James</creatorcontrib><creatorcontrib>Daniell, Mark</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seth, Ishith</au><au>Bulloch, Gabriella</au><au>Vine, Michael</au><au>Outmezguine, Joseph</au><au>Seth, Nimish</au><au>Every, James</au><au>Daniell, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis</atitle><jtitle>Clinical & experimental ophthalmology</jtitle><addtitle>Clin Exp Ophthalmol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>51</volume><issue>4</issue><spage>O1</spage><epage>O16</epage><pages>O1-O16</pages><issn>1442-6404</issn><eissn>1442-9071</eissn><abstract>Background
To investigate the association between keratoconus (KC) and allergic eye diseases, eye rubbing, and atopy.
Methods
PubMed, Web of Science, Scopus, and Cochrane databases were searched for studies investigating eye allergy, atopy, and eye rubbing as risk factors for KC up to April 2021. Two authors independently screened all titles and s against the predefined inclusion and exclusion criteria. The study analysed the prevalence of KC and its risk factors, including eye rubbing, family history of KC, atopy, and allergic eye diseases. The National Institutes of Health Study Quality Assessment Tool was used. Pooled data are presented as odds ratios (OR) and 95% confidence intervals (CI). The analysis was conducted using RevMan version 5.4 software.
Results
The initial search yielded 573 articles. After screening, 21 studies were identified for qualitative analysis and 15 for quantitative synthesis. A significant association was found between KC and eye rubbing (OR = 5.22, 95% CI [2.80, 9.75], p < 0.00001), family history of KC (OR = 6.67, 95% CI [4.77, 9.33], p < 0.00001), and allergies (OR = 2.21, 95% CI [1.57, 3.13], p < 0.00001). However, no significant association was found between KC and allergic eye disease (OR = 1.82, 95% CI [0.37, 8.97], p = 0.46), atopy (OR = 1.54, 95% CI [0.58, 4.09], p = 0.39), allergic rhinitis (OR = 0.85, 95% CI [0.54, 1.33], p = 0.47), smoking (OR = 0.96, 95% CI [0.76, 1.21], p = 0.73), and asthma (OR = 1.58, 95% CI [0.99, 2.53], p = 0.05).
Conclusion
Significant associations were observed between KC and eye rubbing, family history, and allergy, but not with allergic eye disease, atopy, asthma, and allergic rhinitis.
This article can be found online at https://onlinelibrary.wiley.com/doi/10.1111/ceo.14215</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>36882200</pmid><doi>10.1111/ceo.14215</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-5444-8925</orcidid><orcidid>https://orcid.org/0000-0001-9528-7005</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical & experimental ophthalmology, 2023-05, Vol.51 (4), p.O1-O16 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Allergic rhinitis Allergies allergy Asthma Asthma - complications Asthma - epidemiology Atopy Eye diseases eye rubbing Family medical history Hay fever Humans Hypersensitivity Keratoconus Keratoconus - diagnosis Keratoconus - epidemiology Keratoconus - etiology Meta-analysis Odds Ratio Quality control Rhinitis Rhinitis, Allergic - complications Rhinitis, Allergic - epidemiology Risk Factors vernal conjunctivitis |
| title | The association between keratoconus and allergic eye diseases: A systematic review and meta‐analysis |
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