A Novel Finding: 2,4-Di-tert-butylphenol from Streptomyces bacillaris ANS2 Effective Against Mycobacterium tuberculosis and Cancer Cell Lines
The aim of the present study is to identify actinobacteria Streptomyces bacillaris ANS2 as the source of the potentially beneficial compound 2,4-di- tert -butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2023-11, Vol.195 (11), p.6572-6585 |
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| creator | Kaari, Manigundan Joseph, Jerrine Manikkam, Radhakrishnan Kalyanasundaram, Revathy Sivaraj, Anbarasu Anbalmani, Sivarajan Murthy, Sangeetha Sahu, Amit Kumar Said, Madhukar Dastager, Syed G. Ramasamy, Balagurunathan |
| description | The aim of the present study is to identify actinobacteria
Streptomyces bacillaris
ANS2 as the source of the potentially beneficial compound 2,4-di-
tert
-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of
S. bacillaris
ANS2 to produce the bioactive metabolites. Using various chromatographic and spectroscopy analyses, the potential bioactive metabolite separated and identified as 2,4-di-
tert
-butylphenol (2,4-DTBP). The lead compound 2,4-DTBP inhibited 78% and 74% of relative light unit (RLU) decrease against MDR
Mycobacterium tuberculosis
at 100ug/ml and 50ug/ml concentrations, respectively. The Wayne model was used to assess the latent/dormant potential in
M. tuberculosis
H37RV at various doses, and the MIC for the isolated molecule was found to be 100ug/ml. Furthermore, the molecular docking of 2,4-DTBP was docked using Autodock Vinasuite onto the substrate binding site of the target
Mycobacterium
lysine aminotransferase (LAT) and the grid box was configured for the docking run to cover the whole LAT dimer interface. At a dosage of 1 mg/ml, the anti-cancer activity of the compound 2,4-DTBP was 88% and 89% inhibited against the HT 29 (colon cancer) and HeLa (cervical cancer) cell lines. According to our literature survey, this present finding may be the first report on anti-TB activity of 2,4-DTBP and has the potential to become an effective natural source and the promising pharmaceutical drug in the future. |
| doi_str_mv | 10.1007/s12010-023-04403-2 |
| format | Article |
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Streptomyces bacillaris
ANS2 as the source of the potentially beneficial compound 2,4-di-
tert
-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of
S. bacillaris
ANS2 to produce the bioactive metabolites. Using various chromatographic and spectroscopy analyses, the potential bioactive metabolite separated and identified as 2,4-di-
tert
-butylphenol (2,4-DTBP). The lead compound 2,4-DTBP inhibited 78% and 74% of relative light unit (RLU) decrease against MDR
Mycobacterium tuberculosis
at 100ug/ml and 50ug/ml concentrations, respectively. The Wayne model was used to assess the latent/dormant potential in
M. tuberculosis
H37RV at various doses, and the MIC for the isolated molecule was found to be 100ug/ml. Furthermore, the molecular docking of 2,4-DTBP was docked using Autodock Vinasuite onto the substrate binding site of the target
Mycobacterium
lysine aminotransferase (LAT) and the grid box was configured for the docking run to cover the whole LAT dimer interface. At a dosage of 1 mg/ml, the anti-cancer activity of the compound 2,4-DTBP was 88% and 89% inhibited against the HT 29 (colon cancer) and HeLa (cervical cancer) cell lines. According to our literature survey, this present finding may be the first report on anti-TB activity of 2,4-DTBP and has the potential to become an effective natural source and the promising pharmaceutical drug in the future.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/s12010-023-04403-2</identifier><identifier>PMID: 36881320</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acetic acid ; Anticancer properties ; Antitumor activity ; Binding sites ; Bioactive compounds ; Biochemistry ; Biological activity ; Biotechnology ; Cancer ; Cervical cancer ; Chemistry ; Chemistry and Materials Science ; Colon cancer ; Ethyl acetate ; Fermentation ; Lead compounds ; Literature reviews ; Lysine ; Metabolites ; Molecular docking ; Mycobacterium tuberculosis ; Original Article ; Spectroscopy ; Streptomyces ; Substrates ; Tuberculosis ; Tumor cell lines</subject><ispartof>Applied biochemistry and biotechnology, 2023-11, Vol.195 (11), p.6572-6585</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4ca8ca581d8ddec5854e04cf97891e33d95a1f3c2c094cb6ccd80d88e56f15653</citedby><cites>FETCH-LOGICAL-c375t-4ca8ca581d8ddec5854e04cf97891e33d95a1f3c2c094cb6ccd80d88e56f15653</cites><orcidid>0000-0001-7616-8254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12010-023-04403-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12010-023-04403-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36881320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaari, Manigundan</creatorcontrib><creatorcontrib>Joseph, Jerrine</creatorcontrib><creatorcontrib>Manikkam, Radhakrishnan</creatorcontrib><creatorcontrib>Kalyanasundaram, Revathy</creatorcontrib><creatorcontrib>Sivaraj, Anbarasu</creatorcontrib><creatorcontrib>Anbalmani, Sivarajan</creatorcontrib><creatorcontrib>Murthy, Sangeetha</creatorcontrib><creatorcontrib>Sahu, Amit Kumar</creatorcontrib><creatorcontrib>Said, Madhukar</creatorcontrib><creatorcontrib>Dastager, Syed G.</creatorcontrib><creatorcontrib>Ramasamy, Balagurunathan</creatorcontrib><title>A Novel Finding: 2,4-Di-tert-butylphenol from Streptomyces bacillaris ANS2 Effective Against Mycobacterium tuberculosis and Cancer Cell Lines</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><addtitle>Appl Biochem Biotechnol</addtitle><description>The aim of the present study is to identify actinobacteria
Streptomyces bacillaris
ANS2 as the source of the potentially beneficial compound 2,4-di-
tert
-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of
S. bacillaris
ANS2 to produce the bioactive metabolites. Using various chromatographic and spectroscopy analyses, the potential bioactive metabolite separated and identified as 2,4-di-
tert
-butylphenol (2,4-DTBP). The lead compound 2,4-DTBP inhibited 78% and 74% of relative light unit (RLU) decrease against MDR
Mycobacterium tuberculosis
at 100ug/ml and 50ug/ml concentrations, respectively. The Wayne model was used to assess the latent/dormant potential in
M. tuberculosis
H37RV at various doses, and the MIC for the isolated molecule was found to be 100ug/ml. Furthermore, the molecular docking of 2,4-DTBP was docked using Autodock Vinasuite onto the substrate binding site of the target
Mycobacterium
lysine aminotransferase (LAT) and the grid box was configured for the docking run to cover the whole LAT dimer interface. At a dosage of 1 mg/ml, the anti-cancer activity of the compound 2,4-DTBP was 88% and 89% inhibited against the HT 29 (colon cancer) and HeLa (cervical cancer) cell lines. According to our literature survey, this present finding may be the first report on anti-TB activity of 2,4-DTBP and has the potential to become an effective natural source and the promising pharmaceutical drug in the future.</description><subject>Acetic acid</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Binding sites</subject><subject>Bioactive compounds</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cervical cancer</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Colon cancer</subject><subject>Ethyl acetate</subject><subject>Fermentation</subject><subject>Lead compounds</subject><subject>Literature reviews</subject><subject>Lysine</subject><subject>Metabolites</subject><subject>Molecular docking</subject><subject>Mycobacterium tuberculosis</subject><subject>Original 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cancer</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Colon cancer</topic><topic>Ethyl acetate</topic><topic>Fermentation</topic><topic>Lead compounds</topic><topic>Literature reviews</topic><topic>Lysine</topic><topic>Metabolites</topic><topic>Molecular docking</topic><topic>Mycobacterium tuberculosis</topic><topic>Original Article</topic><topic>Spectroscopy</topic><topic>Streptomyces</topic><topic>Substrates</topic><topic>Tuberculosis</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaari, Manigundan</creatorcontrib><creatorcontrib>Joseph, Jerrine</creatorcontrib><creatorcontrib>Manikkam, Radhakrishnan</creatorcontrib><creatorcontrib>Kalyanasundaram, Revathy</creatorcontrib><creatorcontrib>Sivaraj, Anbarasu</creatorcontrib><creatorcontrib>Anbalmani, Sivarajan</creatorcontrib><creatorcontrib>Murthy, Sangeetha</creatorcontrib><creatorcontrib>Sahu, Amit 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Streptomyces bacillaris
ANS2 as the source of the potentially beneficial compound 2,4-di-
tert
-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of
S. bacillaris
ANS2 to produce the bioactive metabolites. Using various chromatographic and spectroscopy analyses, the potential bioactive metabolite separated and identified as 2,4-di-
tert
-butylphenol (2,4-DTBP). The lead compound 2,4-DTBP inhibited 78% and 74% of relative light unit (RLU) decrease against MDR
Mycobacterium tuberculosis
at 100ug/ml and 50ug/ml concentrations, respectively. The Wayne model was used to assess the latent/dormant potential in
M. tuberculosis
H37RV at various doses, and the MIC for the isolated molecule was found to be 100ug/ml. Furthermore, the molecular docking of 2,4-DTBP was docked using Autodock Vinasuite onto the substrate binding site of the target
Mycobacterium
lysine aminotransferase (LAT) and the grid box was configured for the docking run to cover the whole LAT dimer interface. At a dosage of 1 mg/ml, the anti-cancer activity of the compound 2,4-DTBP was 88% and 89% inhibited against the HT 29 (colon cancer) and HeLa (cervical cancer) cell lines. According to our literature survey, this present finding may be the first report on anti-TB activity of 2,4-DTBP and has the potential to become an effective natural source and the promising pharmaceutical drug in the future.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36881320</pmid><doi>10.1007/s12010-023-04403-2</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7616-8254</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Applied biochemistry and biotechnology, 2023-11, Vol.195 (11), p.6572-6585 |
| issn | 0273-2289 1559-0291 |
| language | eng |
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| source | Springer Nature |
| subjects | Acetic acid Anticancer properties Antitumor activity Binding sites Bioactive compounds Biochemistry Biological activity Biotechnology Cancer Cervical cancer Chemistry Chemistry and Materials Science Colon cancer Ethyl acetate Fermentation Lead compounds Literature reviews Lysine Metabolites Molecular docking Mycobacterium tuberculosis Original Article Spectroscopy Streptomyces Substrates Tuberculosis Tumor cell lines |
| title | A Novel Finding: 2,4-Di-tert-butylphenol from Streptomyces bacillaris ANS2 Effective Against Mycobacterium tuberculosis and Cancer Cell Lines |
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