Construction of heterocycle-fused tetrahydrocarbazoles through a formal [3 + 3]-annulation of 2-indolylmethanols with para -quinone methides
A metal-free approach for the synthesis of tetrahydroindolo[2,3- ]carbazoles has been developed through an acid-mediated one-pot [3 + 3]-annulation of 2-indolylmethanols and 3-indolyl-substituted -quinone methides. This operationally simple protocol allowed us to prepare many unsymmetrical tetrahydr...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2023-03, Vol.21 (12), p.2493-2498 |
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| container_issue | 12 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Singh, Gurdeep Sharma, Sonam Pandey, Rajat Rekha Vijaya Anand, Ramasamy |
| description | A metal-free approach for the synthesis of tetrahydroindolo[2,3-
]carbazoles has been developed through an acid-mediated one-pot [3 + 3]-annulation of 2-indolylmethanols and 3-indolyl-substituted
-quinone methides. This operationally simple protocol allowed us to prepare many unsymmetrical tetrahydroindolo[2,3-
]carbazoles in good to excellent yields with a broad substrate scope. This concept was also elaborated to the synthesis of tetrahydrothieno[2,3-
]carbazoles and tetrahydrothieno[3,2-
]carbazoles. |
| doi_str_mv | 10.1039/d3ob00124e |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2023-03, Vol.21 (12), p.2493-2498 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2784385148 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Carbazoles Chemical reactions Chemical synthesis Organic chemistry Quinones Substrates |
| title | Construction of heterocycle-fused tetrahydrocarbazoles through a formal [3 + 3]-annulation of 2-indolylmethanols with para -quinone methides |
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