Effects of gypenoside L‐containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial
This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks...
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| Veröffentlicht in: | Phytotherapy research 2023-07, Vol.37 (7), p.3069-3082 |
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| creator | Ahn, Yejin Lee, Hee‐Seok Lee, Seok‐Hee Joa, Kyung‐Lim Lim, Cho Young Ahn, Yu Jin Suh, Hyung Joo Park, Sung‐Soo Hong, Ki‐Bae |
| description | This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety‐related parameters were compared between the two groups. Maximal oxygen consumption (VO2 max) and O2 pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p |
| doi_str_mv | 10.1002/ptr.7801 |
| format | Article |
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One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety‐related parameters were compared between the two groups. Maximal oxygen consumption (VO2 max) and O2 pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise‐induced physical and mental fatigue.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7801</identifier><identifier>PMID: 36877124</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>clinical trial ; Cognitive ability ; cognitive fatigue ; Double-blind studies ; exercise performance ; Fatigue ; Fatty acids ; Gynostemma ; Gynostemma pentaphyllum ; gypenoside L ; Motor task performance ; Nitric oxide ; Nitric-oxide synthase ; Oral administration ; Oxygen consumption ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use</subject><ispartof>Phytotherapy research, 2023-07, Vol.37 (7), p.3069-3082</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3101-948f0064242e7f730fffb736c9483a8622402a710a37435084197171ff6226c93</cites><orcidid>0000-0001-5199-2685 ; 0000-0003-0319-6670 ; 0000-0001-5879-7997 ; 0000-0002-2171-6847 ; 0000-0001-8869-3929 ; 0000-0002-7016-9798</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7801$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7801$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36877124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Yejin</creatorcontrib><creatorcontrib>Lee, Hee‐Seok</creatorcontrib><creatorcontrib>Lee, Seok‐Hee</creatorcontrib><creatorcontrib>Joa, Kyung‐Lim</creatorcontrib><creatorcontrib>Lim, Cho Young</creatorcontrib><creatorcontrib>Ahn, Yu Jin</creatorcontrib><creatorcontrib>Suh, Hyung Joo</creatorcontrib><creatorcontrib>Park, Sung‐Soo</creatorcontrib><creatorcontrib>Hong, Ki‐Bae</creatorcontrib><title>Effects of gypenoside L‐containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety‐related parameters were compared between the two groups. Maximal oxygen consumption (VO2 max) and O2 pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise‐induced physical and mental fatigue.</description><subject>clinical trial</subject><subject>Cognitive ability</subject><subject>cognitive fatigue</subject><subject>Double-blind studies</subject><subject>exercise performance</subject><subject>Fatigue</subject><subject>Fatty acids</subject><subject>Gynostemma</subject><subject>Gynostemma pentaphyllum</subject><subject>gypenoside L</subject><subject>Motor task performance</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Oral administration</subject><subject>Oxygen consumption</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcuKFDEUhoMoTjsKPoEE3Liwxty6UuVuGOYGDYqM4K5IpU7aDKmkTFJouZpH8Bl8tHmSSTutguDqwPk_vnPgR-g5JUeUEPZmyvFINoQ-QCtK2raia8kfohVp17QStPl0gJ6kdE0IaRkRj9EBrxspKRMr9PPUGNA54WDwdpnAh2QHwJvbmx86-Kyst36Lz5eyzzCOChckq-nz4tw8YviWo9IZB4-NynY7A1Z-wCVOVitX4GhCHJXX8BYf4yHMvYOi7p31w2s8OaWhD_tbMTgHZRuLIoz2Oww4R6vcU_TIKJfg2X4eoo9np1cnF9Xm3fnlyfGm0pwSWrWiMYTUggkG0khOjDG95LUuAVdNzZggTElKFJeCr0kjaCuppMaUqFD8EL26904xfJkh5W60SYNzykOYU8dkw2XLeL1DX_6DXoc5-vJdxxrOZCtIQ_8KdQwpRTDdFO2o4tJR0u1660pv3a63gr7YC-d-hOEP-LuoAlT3wFfrYPmvqHt_9eGX8A531KW1</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Ahn, Yejin</creator><creator>Lee, Hee‐Seok</creator><creator>Lee, Seok‐Hee</creator><creator>Joa, Kyung‐Lim</creator><creator>Lim, Cho Young</creator><creator>Ahn, Yu Jin</creator><creator>Suh, Hyung Joo</creator><creator>Park, Sung‐Soo</creator><creator>Hong, Ki‐Bae</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5199-2685</orcidid><orcidid>https://orcid.org/0000-0003-0319-6670</orcidid><orcidid>https://orcid.org/0000-0001-5879-7997</orcidid><orcidid>https://orcid.org/0000-0002-2171-6847</orcidid><orcidid>https://orcid.org/0000-0001-8869-3929</orcidid><orcidid>https://orcid.org/0000-0002-7016-9798</orcidid></search><sort><creationdate>202307</creationdate><title>Effects of gypenoside L‐containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial</title><author>Ahn, Yejin ; Lee, Hee‐Seok ; Lee, Seok‐Hee ; Joa, Kyung‐Lim ; Lim, Cho Young ; Ahn, Yu Jin ; Suh, Hyung Joo ; Park, Sung‐Soo ; Hong, Ki‐Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3101-948f0064242e7f730fffb736c9483a8622402a710a37435084197171ff6226c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>clinical trial</topic><topic>Cognitive ability</topic><topic>cognitive fatigue</topic><topic>Double-blind studies</topic><topic>exercise performance</topic><topic>Fatigue</topic><topic>Fatty acids</topic><topic>Gynostemma</topic><topic>Gynostemma pentaphyllum</topic><topic>gypenoside L</topic><topic>Motor task performance</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Oral administration</topic><topic>Oxygen consumption</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Yejin</creatorcontrib><creatorcontrib>Lee, Hee‐Seok</creatorcontrib><creatorcontrib>Lee, Seok‐Hee</creatorcontrib><creatorcontrib>Joa, Kyung‐Lim</creatorcontrib><creatorcontrib>Lim, Cho Young</creatorcontrib><creatorcontrib>Ahn, Yu Jin</creatorcontrib><creatorcontrib>Suh, Hyung Joo</creatorcontrib><creatorcontrib>Park, Sung‐Soo</creatorcontrib><creatorcontrib>Hong, Ki‐Bae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Yejin</au><au>Lee, Hee‐Seok</au><au>Lee, Seok‐Hee</au><au>Joa, Kyung‐Lim</au><au>Lim, Cho Young</au><au>Ahn, Yu Jin</au><au>Suh, Hyung Joo</au><au>Park, Sung‐Soo</au><au>Hong, Ki‐Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of gypenoside L‐containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2023-07</date><risdate>2023</risdate><volume>37</volume><issue>7</issue><spage>3069</spage><epage>3082</epage><pages>3069-3082</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>This study was conducted to investigate the effect of Gynostemma pentaphyllum extract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety‐related parameters were compared between the two groups. Maximal oxygen consumption (VO2 max) and O2 pulse were significantly higher in the treatment group than in the control group (p = 0.007 and p = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise‐induced physical and mental fatigue.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>36877124</pmid><doi>10.1002/ptr.7801</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5199-2685</orcidid><orcidid>https://orcid.org/0000-0003-0319-6670</orcidid><orcidid>https://orcid.org/0000-0001-5879-7997</orcidid><orcidid>https://orcid.org/0000-0002-2171-6847</orcidid><orcidid>https://orcid.org/0000-0001-8869-3929</orcidid><orcidid>https://orcid.org/0000-0002-7016-9798</orcidid></addata></record> |
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| ispartof | Phytotherapy research, 2023-07, Vol.37 (7), p.3069-3082 |
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| subjects | clinical trial Cognitive ability cognitive fatigue Double-blind studies exercise performance Fatigue Fatty acids Gynostemma Gynostemma pentaphyllum gypenoside L Motor task performance Nitric oxide Nitric-oxide synthase Oral administration Oxygen consumption Plant Extracts - pharmacology Plant Extracts - therapeutic use |
| title | Effects of gypenoside L‐containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial |
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