Underrepresented Impurities in 4‑Hydroxyphenylpyruvate Affect the Catalytic Activity of Multiple Enzymes

Macrophage migration inhibitory factor (MIF) is a key immunostimulatory protein with regulatory properties in several disorders, including inflammation and cancer. All the reported inhibitors that target the biological activities of MIF have been discovered by testing against its keto/enol tautomera...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-03, Vol.95 (11), p.4957-4965
Hauptverfasser:	Parkins, Andrew, Sandin, Suzanne I., Knittel, Jonathon, Franz, Andreas H., Ren, Jianhua, de Alba, Eva, Pantouris, Georgios
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxyphenylpyruvate dioxygenase Amino acids Analytical chemistry Catalytic activity Catalytic Domain Chemical equilibrium Chemistry Dopachrome isomerase Enzymatic activity Enzyme inhibitors Enzymes Evaluation Humans Immunostimulation Impurities In vivo methods and tests Inflammation Leukocyte migration Macromolecules Macrophage migration inhibitory factor Metabolism Neoplasms NMR Nuclear magnetic resonance Perturbation Phenylpyruvic Acids Pyruvic acid Substrates Tyrosine
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