Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation
Oxidative stress and inflammation are common pathological mechanisms for the progression of tissue degeneration. Epigallocatechin-3-gallate (EGCG) features antioxidant and anti-inflammatory properties, which is a promising drug for the treatment of tissue degeneration. Herein, we utilize the phenylb...
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| Veröffentlicht in: | Carbohydrate polymers 2023-01, Vol.299, p.120180-120180, Article 120180 |
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| container_title | Carbohydrate polymers |
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| creator | He, Zhichao Luo, Huitong Wang, Zetao Chen, Dafu Feng, Qi Cao, Xiaodong |
| description | Oxidative stress and inflammation are common pathological mechanisms for the progression of tissue degeneration. Epigallocatechin-3-gallate (EGCG) features antioxidant and anti-inflammatory properties, which is a promising drug for the treatment of tissue degeneration. Herein, we utilize the phenylborate ester reaction of EGCG and phenylboronic acid (PBA) to fabricate an injectable and tissue adhesive EGCG-laden hydrogel depot (EGCG HYPOT), which can achieve anti-inflammatory and antioxidative effects via smart delivery of EGCG. Specifically, the phenylborate ester bonds, formed by EGCG and PBA-modified methacrylated hyaluronic acid (HAMA-PBA), endow EGCG HYPOT injectability, shape adaptation and efficient load of EGCG. After photo-crosslinking, EGCG HYPOT exhibits good mechanical properties, tissue adhesion and sustained acid-responsive release of EGCG. EGCG HYPOT can scavenge oxygen and nitrogen free radicals. Meanwhile, EGCG HYPOT can scavenge intracellular reactive oxygen species (ROS) and suppress the expression of pro-inflammatory factors. EGCG HYPOT may provide a new idea for alleviation of inflammatory disturbance.
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| doi_str_mv | 10.1016/j.carbpol.2022.120180 |
| format | Article |
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[Display omitted]</description><subject>Antioxidants</subject><subject>Esters</subject><subject>Humans</subject><subject>Hyaluronic Acid</subject><subject>Hydrogels</subject><subject>Inflammation</subject><subject>Injectable hydrogel</subject><subject>Oxidative Stress</subject><subject>Phenylborate ester reaction</subject><subject>Smart EGCG delivery</subject><subject>Tissue Adhesives</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PxCAQhonR6PrxEzQcvXSFQlt6Mmajq4mJFz0TClNlQ2GF1o9_L7qrV-cyL5N33gkPQqeUzCmh9cVqrlXs1sHNS1KWc1oSKsgOmlHRtAVlnO-iGaGcF6KmzQE6TGlFctWU7KMDVoumbtpqht7v_Ar0qDoHWHmDR5vSlKV5gWTfAF8vF8vCKQMev3wqN8XgrcZKW5PfJoZncNjAOoy4DxGPEdRo_TMOH9ZklQNSnqX0k21979Qw5Hnwx2ivVy7BybYfoaeb68fFbXH_sLxbXN0XmtXVWIhK65aLsue8VhRqwgVTphW8a4kiYLI0VdmRnrcVZVVPOtMQ1fYUdFUaA-wInW9y1zG8TpBGOdikwTnlIUxJlo1gjWgIY9labaw6hpQi9HId7aDip6REfjOXK7llLr-Zyw3zvHe2PTF1A5i_rV_I2XC5MUD-6JuFKJO24DUYGzN7aYL958QXuuSXKg</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>He, Zhichao</creator><creator>Luo, Huitong</creator><creator>Wang, Zetao</creator><creator>Chen, Dafu</creator><creator>Feng, Qi</creator><creator>Cao, Xiaodong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230101</creationdate><title>Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation</title><author>He, Zhichao ; Luo, Huitong ; Wang, Zetao ; Chen, Dafu ; Feng, Qi ; Cao, Xiaodong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-85cc9482f446a1e60483ad984b90a0edd98d52b0f495135f0bd70a9f1ec52dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antioxidants</topic><topic>Esters</topic><topic>Humans</topic><topic>Hyaluronic Acid</topic><topic>Hydrogels</topic><topic>Inflammation</topic><topic>Injectable hydrogel</topic><topic>Oxidative Stress</topic><topic>Phenylborate ester reaction</topic><topic>Smart EGCG delivery</topic><topic>Tissue Adhesives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Zhichao</creatorcontrib><creatorcontrib>Luo, Huitong</creatorcontrib><creatorcontrib>Wang, Zetao</creatorcontrib><creatorcontrib>Chen, Dafu</creatorcontrib><creatorcontrib>Feng, Qi</creatorcontrib><creatorcontrib>Cao, Xiaodong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Zhichao</au><au>Luo, Huitong</au><au>Wang, Zetao</au><au>Chen, Dafu</au><au>Feng, Qi</au><au>Cao, Xiaodong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>299</volume><spage>120180</spage><epage>120180</epage><pages>120180-120180</pages><artnum>120180</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>Oxidative stress and inflammation are common pathological mechanisms for the progression of tissue degeneration. Epigallocatechin-3-gallate (EGCG) features antioxidant and anti-inflammatory properties, which is a promising drug for the treatment of tissue degeneration. Herein, we utilize the phenylborate ester reaction of EGCG and phenylboronic acid (PBA) to fabricate an injectable and tissue adhesive EGCG-laden hydrogel depot (EGCG HYPOT), which can achieve anti-inflammatory and antioxidative effects via smart delivery of EGCG. Specifically, the phenylborate ester bonds, formed by EGCG and PBA-modified methacrylated hyaluronic acid (HAMA-PBA), endow EGCG HYPOT injectability, shape adaptation and efficient load of EGCG. After photo-crosslinking, EGCG HYPOT exhibits good mechanical properties, tissue adhesion and sustained acid-responsive release of EGCG. EGCG HYPOT can scavenge oxygen and nitrogen free radicals. Meanwhile, EGCG HYPOT can scavenge intracellular reactive oxygen species (ROS) and suppress the expression of pro-inflammatory factors. EGCG HYPOT may provide a new idea for alleviation of inflammatory disturbance.
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antioxidants Esters Humans Hyaluronic Acid Hydrogels Inflammation Injectable hydrogel Oxidative Stress Phenylborate ester reaction Smart EGCG delivery Tissue Adhesives |
| title | Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation |
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