Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although the selective inactivation of MeCP2 in neurons is sufficient to confer a Rett-like phen...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-10, Vol.301 (5646), p.885-889
Hauptverfasser:	Chen, W G, Chang, Q, Lin, Y, Meissner, A, West, A E, Griffith, E C, Jaenisch, R, Greenberg, M E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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