Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes
Purpose Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of thes...
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Veröffentlicht in: | Japanese journal of ophthalmology 2023-05, Vol.67 (3), p.295-300 |
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creator | Yamada-Okahara, Naoko Kyo, Akika Hirayama, Kumiko Yamamoto, Manabu Kohno, Takeya Honda, Shigeru |
description | Purpose
Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities.
Study design
A retrospective interventional study.
Methods
The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months’ visual and anatomical outcomes of each modality were assessed.
Results
The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p |
doi_str_mv | 10.1007/s10384-023-00978-9 |
format | Article |
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Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities.
Study design
A retrospective interventional study.
Methods
The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months’ visual and anatomical outcomes of each modality were assessed.
Results
The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p<0.005). The dry macula ratio at 3 months post-treatment was 29%, 59%, and 81% in the PC, SRT, and PDT groups, respectively, which significantly differed among the groups (p<0.01). The best-corrected visual acuities tended to be improved after the treatments in all groups. Central choroidal thickness (CCT) was significantly decreased in all groups (p<0.05, p<0.01, and p<0.00001, in PC, SRT, and PDT groups, respectively). Logistic regression analysis for dry macula revealed that SRT (p<0.05), PDT (p<0.05), and the changes in CCT (p<0.01)were the significant association factors.
Conclusion
The leakage pattern in FA was associated with the choice of treatment option for pCSC. PDT achieved a significantly higher dry macula ratio than PC, 3 months after the treatment.]]></description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-023-00978-9</identifier><identifier>PMID: 36867256</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Angiography ; Central Serous Chorioretinopathy - drug therapy ; Central Serous Chorioretinopathy - therapy ; Chronic Disease ; Clinical Investigation ; Eye (anatomy) ; Fluorescein Angiography ; Humans ; Leakage ; Medicine ; Medicine & Public Health ; Ophthalmology ; Photochemotherapy ; Photodynamic therapy ; Photosensitizing Agents - therapeutic use ; Porphyrins ; Regression analysis ; Retina ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity</subject><ispartof>Japanese journal of ophthalmology, 2023-05, Vol.67 (3), p.295-300</ispartof><rights>Japanese Ophthalmological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Japanese Ophthalmological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-db2b2c6cd71fef9739af1c246199c205abd1b7f5cf59b8073ce4a30a9657b7c83</citedby><cites>FETCH-LOGICAL-c492t-db2b2c6cd71fef9739af1c246199c205abd1b7f5cf59b8073ce4a30a9657b7c83</cites><orcidid>0000-0002-0632-997X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-023-00978-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-023-00978-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36867256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada-Okahara, Naoko</creatorcontrib><creatorcontrib>Kyo, Akika</creatorcontrib><creatorcontrib>Hirayama, Kumiko</creatorcontrib><creatorcontrib>Yamamoto, Manabu</creatorcontrib><creatorcontrib>Kohno, Takeya</creatorcontrib><creatorcontrib>Honda, Shigeru</creatorcontrib><title>Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description><![CDATA[Purpose
Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities.
Study design
A retrospective interventional study.
Methods
The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months’ visual and anatomical outcomes of each modality were assessed.
Results
The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p<0.005). The dry macula ratio at 3 months post-treatment was 29%, 59%, and 81% in the PC, SRT, and PDT groups, respectively, which significantly differed among the groups (p<0.01). The best-corrected visual acuities tended to be improved after the treatments in all groups. Central choroidal thickness (CCT) was significantly decreased in all groups (p<0.05, p<0.01, and p<0.00001, in PC, SRT, and PDT groups, respectively). Logistic regression analysis for dry macula revealed that SRT (p<0.05), PDT (p<0.05), and the changes in CCT (p<0.01)were the significant association factors.
Conclusion
The leakage pattern in FA was associated with the choice of treatment option for pCSC. PDT achieved a significantly higher dry macula ratio than PC, 3 months after the treatment.]]></description><subject>Angiography</subject><subject>Central Serous Chorioretinopathy - drug therapy</subject><subject>Central Serous Chorioretinopathy - therapy</subject><subject>Chronic Disease</subject><subject>Clinical Investigation</subject><subject>Eye (anatomy)</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Leakage</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Porphyrins</subject><subject>Regression analysis</subject><subject>Retina</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LxDAQhoMo7rr6BzxIwYuX6iRpmuYoi1-woAc9hzRN3S5tU5NU2H9v9kMFD14SmDzzToYHoXMM1xiA33gMtMhSIDQFELxIxQGa4hzTlJAsP0RTAIJThhmboBPvVwCQEUqO0YTmRc4Jy6covDilQ6NVmwRnVOhMHxI7hMb2PqmtSwbjfOPDpqzj4SLojbOjT_TSusY6E5reDios14nqq8Qo166Tz8aPkdwUVK-C7bYT7Bi07Yw_RUe1ar05298z9HZ_9zp_TBfPD0_z20WqM0FCWpWkJDrXFce1qQWnQtVYx9WwEJoAU2WFS14zXTNRFsCpNpmioETOeMl1QWfoapc7OPsxGh9k13ht2lb1Jm4gCS9oJgpgG_TyD7qyo-vj7yQpMKMZwxwiRXaUdtZ7Z2o5uKZTbi0xyI0TuXMioxO5dSJFbLrYR49lZ6qflm8JEaA7wMen_t2439n_xH4BjhKaFA</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Yamada-Okahara, Naoko</creator><creator>Kyo, Akika</creator><creator>Hirayama, Kumiko</creator><creator>Yamamoto, Manabu</creator><creator>Kohno, Takeya</creator><creator>Honda, Shigeru</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0632-997X</orcidid></search><sort><creationdate>20230501</creationdate><title>Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes</title><author>Yamada-Okahara, Naoko ; Kyo, Akika ; Hirayama, Kumiko ; Yamamoto, Manabu ; Kohno, Takeya ; Honda, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-db2b2c6cd71fef9739af1c246199c205abd1b7f5cf59b8073ce4a30a9657b7c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiography</topic><topic>Central Serous Chorioretinopathy - drug therapy</topic><topic>Central Serous Chorioretinopathy - therapy</topic><topic>Chronic Disease</topic><topic>Clinical Investigation</topic><topic>Eye (anatomy)</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Leakage</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Porphyrins</topic><topic>Regression analysis</topic><topic>Retina</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada-Okahara, Naoko</creatorcontrib><creatorcontrib>Kyo, Akika</creatorcontrib><creatorcontrib>Hirayama, Kumiko</creatorcontrib><creatorcontrib>Yamamoto, Manabu</creatorcontrib><creatorcontrib>Kohno, Takeya</creatorcontrib><creatorcontrib>Honda, Shigeru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada-Okahara, Naoko</au><au>Kyo, Akika</au><au>Hirayama, Kumiko</au><au>Yamamoto, Manabu</au><au>Kohno, Takeya</au><au>Honda, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>67</volume><issue>3</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract><![CDATA[Purpose
Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities.
Study design
A retrospective interventional study.
Methods
The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months’ visual and anatomical outcomes of each modality were assessed.
Results
The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p<0.005). The dry macula ratio at 3 months post-treatment was 29%, 59%, and 81% in the PC, SRT, and PDT groups, respectively, which significantly differed among the groups (p<0.01). The best-corrected visual acuities tended to be improved after the treatments in all groups. Central choroidal thickness (CCT) was significantly decreased in all groups (p<0.05, p<0.01, and p<0.00001, in PC, SRT, and PDT groups, respectively). Logistic regression analysis for dry macula revealed that SRT (p<0.05), PDT (p<0.05), and the changes in CCT (p<0.01)were the significant association factors.
Conclusion
The leakage pattern in FA was associated with the choice of treatment option for pCSC. PDT achieved a significantly higher dry macula ratio than PC, 3 months after the treatment.]]></abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>36867256</pmid><doi>10.1007/s10384-023-00978-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0632-997X</orcidid></addata></record> |
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subjects | Angiography Central Serous Chorioretinopathy - drug therapy Central Serous Chorioretinopathy - therapy Chronic Disease Clinical Investigation Eye (anatomy) Fluorescein Angiography Humans Leakage Medicine Medicine & Public Health Ophthalmology Photochemotherapy Photodynamic therapy Photosensitizing Agents - therapeutic use Porphyrins Regression analysis Retina Retrospective Studies Tomography, Optical Coherence Visual Acuity |
title | Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes |
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