New lipophilic organic nitrates: candidates for chronic skin disease therapy

Organic nitrates are widely used, but their chronic efficacy is blunted due to the development of tolerance. The properties of new tolerance free organic nitrates were studied. Their lipophilicity profile and passive diffusion across polydimethylsiloxane membrane and pig ear-skin, and their efficacy...

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Veröffentlicht in:Biological chemistry 2023-05, Vol.404 (6), p.601-606
Hauptverfasser: Marini, Elisabetta, Sodano, Federica, Rolando, Barbara, Chegaev, Konstantin, Maresca, Daniela Claudia, Ianaro, Angela, Ercolano, Giuseppe, Lazzarato, Loretta
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Sprache:eng
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