Loss of p53 Concurrent with RAS and TERT Activation Induces Glioma Formation

There is an ongoing debate regarding whether gliomas originate due to functional or genetic changes in neural stem cells (NSCs). Genetic engineering has made it possible to use NSCs to establish glioma models with the pathological features of human tumors. Here, we found that RAS , TERT , and p53 mu...

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Veröffentlicht in:	Molecular neurobiology 2023-06, Vol.60 (6), p.3452-3463
Hauptverfasser:	Gong, Meiting, Fan, Xiaoqing, Yu, Huihan, Niu, Wanxiang, Sun, Suling, Wang, Hongzhi, Chen, Xueran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain Neoplasms - pathology Brain tumors Cell Biology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology DNA methyltransferase Genetic engineering Genetic transformation Glial fibrillary acidic protein Glioma Glioma - pathology Humans Mice MicroRNAs Mutation - genetics Neural stem cells Neural Stem Cells - metabolism Neurobiology Neurology Neurosciences Oct-4 protein p53 Protein Palmitoylation ras Proteins - metabolism Stem cells Telomerase - genetics Telomerase - metabolism Transplantation Tumor Suppressor Protein p53 - metabolism
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