Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm
Some studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) we...
Gespeichert in:
| Veröffentlicht in: | Odontology 2023-10, Vol.111 (4), p.1009-1017 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1017 |
|---|---|
| container_issue | 4 |
| container_start_page | 1009 |
| container_title | Odontology |
| container_volume | 111 |
| creator | Sari, Aysegul Dikmen, Nursel Kaya Nibali, Luigi |
| description | Some studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann–Whitney
U
test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (
p
|
| doi_str_mv | 10.1007/s10266-023-00797-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2783496475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2783496475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-94a70e7b53ca59fbeec8e4bf1a336c2b54e8eeff17fd95df345a9234bd951a4b3</originalsourceid><addsrcrecordid>eNp9kc1O3DAUhS1UBNNpX4AFstQNmxT_xU66Q0N_kJDY0G4tx7kGjzL2YCeC2fEOfUOeBMNQkLpgZV-f7xxbPggdUPKVEqKOMyVMyoowXpWxVdXdDppRSZuKsrr-8LoXah99zHlJCFOCkz20z2UjFWvIDMWTnKP1ZvQx4A7GW4CA15B87GMYzYB7n8FkyNiEHi8u_pydVrTFPjiwT55v2GBb9If7v7YYUhxwHqd-g2_9eF20IYYrXw58KFkmrT6hXWeGDJ9f1jn6_eP75eJXdX7x82xxcl5ZQduxaoVRBFRXc2vq1nUAtgHROWo4l5Z1tYAGwDmqXN_WveOiNi3joisTNaLjc3S0zV2neDNBHvXKZwvDYALEKWumGi5aKVRd0C__ocs4pfLeQjWSEy4poYViW8qmmHMCp9fJr0zaaEr0Ux16W4cudejnOvRdMR2-RE_dCvpXy7__LwDfArlI4QrS293vxD4CC-2YGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2863036101</pqid></control><display><type>article</type><title>Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm</title><source>SpringerNature Journals</source><creator>Sari, Aysegul ; Dikmen, Nursel Kaya ; Nibali, Luigi</creator><creatorcontrib>Sari, Aysegul ; Dikmen, Nursel Kaya ; Nibali, Luigi</creatorcontrib><description>Some studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann–Whitney
U
test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (
p
< 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (
p
< 0.05) in the test group. Presence of periodontitis (
p
= 0.015) was higher and periodontal health was lower (
p
= 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (
p
< 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23–2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.</description><identifier>ISSN: 1618-1247</identifier><identifier>EISSN: 1618-1255</identifier><identifier>DOI: 10.1007/s10266-023-00797-x</identifier><identifier>PMID: 36867280</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Cell number ; COVID-19 ; Dentistry ; Ferritin ; Gum disease ; Inflammation ; Leukocytes (neutrophilic) ; Lymphocytes ; Medicine ; Oral and Maxillofacial Surgery ; Original Article ; Patients ; Periodontal diseases ; Periodontitis ; Plaque index ; Regression analysis</subject><ispartof>Odontology, 2023-10, Vol.111 (4), p.1009-1017</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-94a70e7b53ca59fbeec8e4bf1a336c2b54e8eeff17fd95df345a9234bd951a4b3</citedby><cites>FETCH-LOGICAL-c419t-94a70e7b53ca59fbeec8e4bf1a336c2b54e8eeff17fd95df345a9234bd951a4b3</cites><orcidid>0000-0002-5923-400X ; 0000-0001-6180-9776 ; 0000-0002-7750-5010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10266-023-00797-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10266-023-00797-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36867280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sari, Aysegul</creatorcontrib><creatorcontrib>Dikmen, Nursel Kaya</creatorcontrib><creatorcontrib>Nibali, Luigi</creatorcontrib><title>Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm</title><title>Odontology</title><addtitle>Odontology</addtitle><addtitle>Odontology</addtitle><description>Some studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann–Whitney
U
test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (
p
< 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (
p
< 0.05) in the test group. Presence of periodontitis (
p
= 0.015) was higher and periodontal health was lower (
p
= 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (
p
< 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23–2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.</description><subject>Cell number</subject><subject>COVID-19</subject><subject>Dentistry</subject><subject>Ferritin</subject><subject>Gum disease</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Medicine</subject><subject>Oral and Maxillofacial Surgery</subject><subject>Original Article</subject><subject>Patients</subject><subject>Periodontal diseases</subject><subject>Periodontitis</subject><subject>Plaque index</subject><subject>Regression analysis</subject><issn>1618-1247</issn><issn>1618-1255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kc1O3DAUhS1UBNNpX4AFstQNmxT_xU66Q0N_kJDY0G4tx7kGjzL2YCeC2fEOfUOeBMNQkLpgZV-f7xxbPggdUPKVEqKOMyVMyoowXpWxVdXdDppRSZuKsrr-8LoXah99zHlJCFOCkz20z2UjFWvIDMWTnKP1ZvQx4A7GW4CA15B87GMYzYB7n8FkyNiEHi8u_pydVrTFPjiwT55v2GBb9If7v7YYUhxwHqd-g2_9eF20IYYrXw58KFkmrT6hXWeGDJ9f1jn6_eP75eJXdX7x82xxcl5ZQduxaoVRBFRXc2vq1nUAtgHROWo4l5Z1tYAGwDmqXN_WveOiNi3joisTNaLjc3S0zV2neDNBHvXKZwvDYALEKWumGi5aKVRd0C__ocs4pfLeQjWSEy4poYViW8qmmHMCp9fJr0zaaEr0Ux16W4cudejnOvRdMR2-RE_dCvpXy7__LwDfArlI4QrS293vxD4CC-2YGA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Sari, Aysegul</creator><creator>Dikmen, Nursel Kaya</creator><creator>Nibali, Luigi</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5923-400X</orcidid><orcidid>https://orcid.org/0000-0001-6180-9776</orcidid><orcidid>https://orcid.org/0000-0002-7750-5010</orcidid></search><sort><creationdate>20231001</creationdate><title>Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm</title><author>Sari, Aysegul ; Dikmen, Nursel Kaya ; Nibali, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-94a70e7b53ca59fbeec8e4bf1a336c2b54e8eeff17fd95df345a9234bd951a4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell number</topic><topic>COVID-19</topic><topic>Dentistry</topic><topic>Ferritin</topic><topic>Gum disease</topic><topic>Inflammation</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Medicine</topic><topic>Oral and Maxillofacial Surgery</topic><topic>Original Article</topic><topic>Patients</topic><topic>Periodontal diseases</topic><topic>Periodontitis</topic><topic>Plaque index</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sari, Aysegul</creatorcontrib><creatorcontrib>Dikmen, Nursel Kaya</creatorcontrib><creatorcontrib>Nibali, Luigi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Odontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sari, Aysegul</au><au>Dikmen, Nursel Kaya</au><au>Nibali, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm</atitle><jtitle>Odontology</jtitle><stitle>Odontology</stitle><addtitle>Odontology</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>111</volume><issue>4</issue><spage>1009</spage><epage>1017</epage><pages>1009-1017</pages><issn>1618-1247</issn><eissn>1618-1255</eissn><abstract>Some studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann–Whitney
U
test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (
p
< 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (
p
< 0.05) in the test group. Presence of periodontitis (
p
= 0.015) was higher and periodontal health was lower (
p
= 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (
p
< 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23–2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36867280</pmid><doi>10.1007/s10266-023-00797-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5923-400X</orcidid><orcidid>https://orcid.org/0000-0001-6180-9776</orcidid><orcidid>https://orcid.org/0000-0002-7750-5010</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1618-1247 |
| ispartof | Odontology, 2023-10, Vol.111 (4), p.1009-1017 |
| issn | 1618-1247 1618-1255 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2783496475 |
| source | SpringerNature Journals |
| subjects | Cell number COVID-19 Dentistry Ferritin Gum disease Inflammation Leukocytes (neutrophilic) Lymphocytes Medicine Oral and Maxillofacial Surgery Original Article Patients Periodontal diseases Periodontitis Plaque index Regression analysis |
| title | Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T09%3A25%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20periodontal%20diseases%20and%20COVID-19%20infection:%20a%20case%E2%80%93control%20study%20with%20a%20longitudinal%20arm&rft.jtitle=Odontology&rft.au=Sari,%20Aysegul&rft.date=2023-10-01&rft.volume=111&rft.issue=4&rft.spage=1009&rft.epage=1017&rft.pages=1009-1017&rft.issn=1618-1247&rft.eissn=1618-1255&rft_id=info:doi/10.1007/s10266-023-00797-x&rft_dat=%3Cproquest_cross%3E2783496475%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2863036101&rft_id=info:pmid/36867280&rfr_iscdi=true |