Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration

Adrenomedullin 2 (AM2; also known as intermedin) is a member of the adrenomedullin (AM) peptide family. Similarly to AM, AM2 partakes in a variety of physiological activities. AM2 has been reported to exert protective effects on various organ disorders; however, its significance in the eye is unknow...

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Veröffentlicht in:	Laboratory investigation 2023-04, Vol.103 (4), p.100038-100038, Article 100038
Hauptverfasser:	Kakihara, Shinji, Matsuda, Yorishige, Hirabayashi, Kazutaka, Imai, Akira, Iesato, Yasuhiro, Sakurai, Takayuki, Kamiyoshi, Akiko, Tanaka, Megumu, Ichikawa-Shindo, Yuka, Kawate, Hisaka, Zhao, Yunlu, Zhang, Yan, Guo, QianQian, Li, Peixuan, Onishi, Naho, Murata, Toshinori, Shindo, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin - genetics Adrenomedullin - pharmacology Adrenomedullin - therapeutic use adrenomedullin 2 Animals Choroidal Neovascularization - drug therapy Choroidal Neovascularization - genetics Endothelial Cells - metabolism Fibrosis Humans Inflammation - pathology laser-induced choroidal neovascularization Macular Degeneration - genetics Macular Degeneration - metabolism Macular Degeneration - pathology mesenchyme homeobox 2 Mice neovascular age-related macular degeneration Neuropeptides - therapeutic use
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