Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2PB/+ Gen1PB/+ mice

Congenital anomalies of the kidney and urinary tract (CAKUT) have been attributed to genetic and environmental factors. However, monogenic and copy number variations cannot sufficiently explain the cause of the majority of CAKUT cases. Multiple genes through various modes of inheritance may lead to...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-04, Vol.653, p.153-160
Hauptverfasser:	Du, Xuanjin, Yu, Minghui, Ju, Haixin, Xue, Shanshan, Li, Yaxin, Wu, Xiaohui, Xu, Hong, Shen, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Congenital anomalies of the kidney and urinary tract GEN1 Holliday junction 5′ flap endonuclease MAPK/ERK Roundabout guidance receptor 2 U0126
Online-Zugang:	Volltext
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