Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches

Microtubule affinity regulating kinase 4 (MARK4), 752 amino acids long, belonging to the AMPK superfamily, plays a vital role in regulating microtubules due to its potential to phosphorylate microtubule-associated proteins (MAP's) and thus, MARK4 plays a key role in Alzheimer's disease (AD...

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Veröffentlicht in:	International journal of biological macromolecules 2023-04, Vol.235, p.123831-123831, Article 123831
Hauptverfasser:	Alrouji, Mohammed, DasGupta, Debarati, Ashraf, Ghulam Md, Bilgrami, Anwar L., Alhumaydhi, Fahad A., Al Abdulmonem, Waleed, Shahwan, Moyad, Alsayari, Abdulrhman, Atiya, Akhtar, Shamsi, Anas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Acetylcholinesterase inhibitors Cholinesterase Inhibitors - metabolism Cholinesterase Inhibitors - pharmacology Isothermal titration calorimetry Kinase inhibitors Microtubules - metabolism Molecular docking Molecular Docking Simulation Molecular dynamic simulation Protein Binding Protein Serine-Threonine Kinases - metabolism
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