The effect of adjusting LDL-cholesterol for Lp(a)-cholesterol on the diagnosis of familial hypercholesterolaemia

•Lp(a)-associated cholesterol is not accounted for in the Friedwald equation.•Adjusting estimated LDL-C by Lp(a) improves accuracy of FH diagnostic criteria.•However, this approach may lead to patients with an FH mutation being missed. Familial hypercholesterolaemia (FH) diagnostic tools help priori...

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Veröffentlicht in:	Journal of clinical lipidology 2023-03, Vol.17 (2), p.244-254
Hauptverfasser:	Thayabaran, Darmiga, Tsui, Anson P.T., Ebmeier, Stefan, Cegla, Jaimini, David, Alessia, Jones, Ben
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cholesterol, LDL - genetics Dutch Lipid Clinic Network criteria Familial hypercholesterolaemia Genetic Testing Humans Hyperlipoproteinemia Type II - diagnosis Hyperlipoproteinemia Type II - genetics LDL-cholesterol Lipoprotein(a) Lipoprotein(a) - genetics Mutation Simon Broome criteria
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