Characterization of fibronectin properties by integrated micro-fluidic experiments and fluid-structure interaction simulations

Fibronectin (Fn) has been observed to assemble in the extracellular matrix (ECM) of cell culture and stretch in response to the external force. The alteration of molecule domain functions generally follows the extension of Fn. Several researchers have investigated fibronectin extensively in molecula...

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Veröffentlicht in:	Journal of biomechanics 2023-03, Vol.150, p.111505-111505, Article 111505
Hauptverfasser:	Ke, Renjie, Kucukal, Erdem, Gurkan, Umut A., Li, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Cell adhesion & migration Cell culture Computer applications Conformation Constitutive models Cytoplasm Deformation Deformation effects Entanglement Erythrocytes Erythrocytes - metabolism Extracellular matrix Extracellular Matrix - metabolism Fibronectin Fibronectins - analysis Fibronectins - chemistry Fibronectins - metabolism Finite element method Fluid-structure interaction Integrated framework Material properties Mechanical Phenomena Mesh-free Methods Micro-fluidic experiments Microfluidics Molecular Conformation Molecular structure Numerical prediction Optimization algorithms Physiology Red blood cells Rheological properties Robustness (mathematics) Simulation Software Stress distribution Stress measurement Stress, Mechanical Viscoelasticity
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