A versatile drug-controlled release polymer brush hybrid non-glutaraldehyde bioprosthetic heart valves with enhanced anti-inflammatory, anticoagulant and anti-calcification properties, and superior mechanical performance
Transcatheter heart valve replacement (THVR) is a novel treatment modality for severe heart valves diseases and has become the main method for the treatment of heart valve diseases in recent years. However, the lifespan of the commercial glutaraldehyde cross-linked bioprosthetic heart valves (BHVs)...
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| Veröffentlicht in: | Biomaterials 2023-05, Vol.296, p.122070-122070, Article 122070 |
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| creator | Yu, Tao Li, Gaocan Chen, Xiaotong Kuang, Dajun Jiang, Qing Guo, Yingqiang Wang, Yunbing |
| description | Transcatheter heart valve replacement (THVR) is a novel treatment modality for severe heart valves diseases and has become the main method for the treatment of heart valve diseases in recent years. However, the lifespan of the commercial glutaraldehyde cross-linked bioprosthetic heart valves (BHVs) used in THVR can only serve for 10–15 years, and the essential reason for the failure of the valve leaflet material is due to these problems such as calcification, coagulation, and inflammation caused by glutaraldehyde cross-linking. Herein, a kind of novel non-glutaraldehyde cross-linking agent bromo-bicyclic-oxazolidine (OX-Br) has been designed and synthesized with both crosslinking ability and in-situ atom transfer radical polymerization (ATRP) function. Then OX-Br treated porcine pericardium (OX-Br-PP) are stepwise modified with co-polymer brushes of reactive oxygen species (ROS) response anti-inflammatory drug conjugated block and anti-adhesion polyzwitterion polymer block through the in-situ ATRP reaction to obtain the functional BHV material MPQ@OX-PP. Along with the great mechanical properties and anti-enzymatic degradation ability similar to glutaraldehyde-crosslinked porcine pericardium (Glut-PP), good biocompatibility, improved anti-inflammatory effect, robust anti-coagulant ability and superior anti-calcification property have been verified for MPQ@OX-PP by a series of in vitro and in vivo investigations, indicating the excellent application potential as a multifunctional heart valve cross-linking agent for OX-Br. Meanwhile, the strategy of synergistic effect with in situ generations of reactive oxygen species-responsive anti-inflammatory drug blocks and anti-adhesion polymer brushes can effectively meet the requirement of multifaceted performance of bioprosthetic heart valves and provide a valuable reference for other blood contacting materials and functional implantable materials with great comprehensive performance.
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| doi_str_mv | 10.1016/j.biomaterials.2023.122070 |
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[Display omitted]</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2023.122070</identifier><identifier>PMID: 36868031</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Anti-calcification ; Anti-coagulant ; Anti-inflammatory ; Anti-Inflammatory Agents - metabolism ; Anticoagulants - pharmacology ; Bioprosthesis ; Calcinosis - metabolism ; Crosslinking ; Delayed-Action Preparations - metabolism ; Glutaral ; Heart Valve Prosthesis ; Heart Valves ; Pericardium - metabolism ; Polymers - metabolism ; Reactive Oxygen Species - metabolism ; Swine</subject><ispartof>Biomaterials, 2023-05, Vol.296, p.122070-122070, Article 122070</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-7721e4ad21b222123fcd0e3d5036aa84a0b2dbba871ec65bf10a5bb5675bffab3</citedby><cites>FETCH-LOGICAL-c380t-7721e4ad21b222123fcd0e3d5036aa84a0b2dbba871ec65bf10a5bb5675bffab3</cites><orcidid>0000-0002-2412-6762 ; 0000-0002-8736-6368</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2023.122070$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36868031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Li, Gaocan</creatorcontrib><creatorcontrib>Chen, Xiaotong</creatorcontrib><creatorcontrib>Kuang, Dajun</creatorcontrib><creatorcontrib>Jiang, Qing</creatorcontrib><creatorcontrib>Guo, Yingqiang</creatorcontrib><creatorcontrib>Wang, Yunbing</creatorcontrib><title>A versatile drug-controlled release polymer brush hybrid non-glutaraldehyde bioprosthetic heart valves with enhanced anti-inflammatory, anticoagulant and anti-calcification properties, and superior mechanical performance</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Transcatheter heart valve replacement (THVR) is a novel treatment modality for severe heart valves diseases and has become the main method for the treatment of heart valve diseases in recent years. However, the lifespan of the commercial glutaraldehyde cross-linked bioprosthetic heart valves (BHVs) used in THVR can only serve for 10–15 years, and the essential reason for the failure of the valve leaflet material is due to these problems such as calcification, coagulation, and inflammation caused by glutaraldehyde cross-linking. Herein, a kind of novel non-glutaraldehyde cross-linking agent bromo-bicyclic-oxazolidine (OX-Br) has been designed and synthesized with both crosslinking ability and in-situ atom transfer radical polymerization (ATRP) function. Then OX-Br treated porcine pericardium (OX-Br-PP) are stepwise modified with co-polymer brushes of reactive oxygen species (ROS) response anti-inflammatory drug conjugated block and anti-adhesion polyzwitterion polymer block through the in-situ ATRP reaction to obtain the functional BHV material MPQ@OX-PP. Along with the great mechanical properties and anti-enzymatic degradation ability similar to glutaraldehyde-crosslinked porcine pericardium (Glut-PP), good biocompatibility, improved anti-inflammatory effect, robust anti-coagulant ability and superior anti-calcification property have been verified for MPQ@OX-PP by a series of in vitro and in vivo investigations, indicating the excellent application potential as a multifunctional heart valve cross-linking agent for OX-Br. Meanwhile, the strategy of synergistic effect with in situ generations of reactive oxygen species-responsive anti-inflammatory drug blocks and anti-adhesion polymer brushes can effectively meet the requirement of multifaceted performance of bioprosthetic heart valves and provide a valuable reference for other blood contacting materials and functional implantable materials with great comprehensive performance.
[Display omitted]</description><subject>Animals</subject><subject>Anti-calcification</subject><subject>Anti-coagulant</subject><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Anticoagulants - pharmacology</subject><subject>Bioprosthesis</subject><subject>Calcinosis - metabolism</subject><subject>Crosslinking</subject><subject>Delayed-Action Preparations - metabolism</subject><subject>Glutaral</subject><subject>Heart Valve Prosthesis</subject><subject>Heart Valves</subject><subject>Pericardium - metabolism</subject><subject>Polymers - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Swine</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuOEzEQRVsIxISBX0AWKxbTwXY_w240PKWR2MDaKtvVaUfudrDdGeVf-Rgqk4BYsnJV6fjW4xbFG8HXgov23W6tXZggY3Tg01pyWa2FlLzjT4qV6Lu-bDa8eVqsuKhluWmFvCpepLTjlPNaPi-uqrZve16JVfHrlh0wJsjOI7Nx2ZYmzDkG79GyiB4hIdsHf5wwMh2XNLLxqKOzbA5zufVLhgje4ni0yGisfQwpj5idYSNCzOwA_oCJPbg8MpxHmA0Jw5xd6ebBw0R7hHi8eSyZANvFU0TZBTLgjRucoQHDzEh9jzE7TDePSFoodSGyCQ1JE-YZVYYQp1Ojl8WzgS6Ery7vdfHj08fvd1_K-2-fv97d3pem6nkuu04KrMFKoaWUQlaDsRwr2_CqBehr4FparaHvBJq20YPg0GjdtB3FA-jqunh71qX5fi6YsppcMuhpFQxLUrLrq3pT95Ug9P0ZNXSoFHFQ--gmiEcluDq5q3bqX3fVyV11dpc-v770WfSE9u_XP3YS8OEMIG17cBhVMg5PJ3cRTVY2uP_p8xv2ssX1</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Yu, Tao</creator><creator>Li, Gaocan</creator><creator>Chen, Xiaotong</creator><creator>Kuang, Dajun</creator><creator>Jiang, Qing</creator><creator>Guo, Yingqiang</creator><creator>Wang, Yunbing</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2412-6762</orcidid><orcidid>https://orcid.org/0000-0002-8736-6368</orcidid></search><sort><creationdate>202305</creationdate><title>A versatile drug-controlled release polymer brush hybrid non-glutaraldehyde bioprosthetic heart valves with enhanced anti-inflammatory, anticoagulant and anti-calcification properties, and superior mechanical performance</title><author>Yu, Tao ; Li, Gaocan ; Chen, Xiaotong ; Kuang, Dajun ; Jiang, Qing ; Guo, Yingqiang ; Wang, Yunbing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-7721e4ad21b222123fcd0e3d5036aa84a0b2dbba871ec65bf10a5bb5675bffab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-calcification</topic><topic>Anti-coagulant</topic><topic>Anti-inflammatory</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Anticoagulants - pharmacology</topic><topic>Bioprosthesis</topic><topic>Calcinosis - metabolism</topic><topic>Crosslinking</topic><topic>Delayed-Action Preparations - metabolism</topic><topic>Glutaral</topic><topic>Heart Valve Prosthesis</topic><topic>Heart Valves</topic><topic>Pericardium - metabolism</topic><topic>Polymers - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Li, Gaocan</creatorcontrib><creatorcontrib>Chen, Xiaotong</creatorcontrib><creatorcontrib>Kuang, Dajun</creatorcontrib><creatorcontrib>Jiang, Qing</creatorcontrib><creatorcontrib>Guo, Yingqiang</creatorcontrib><creatorcontrib>Wang, Yunbing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Tao</au><au>Li, Gaocan</au><au>Chen, Xiaotong</au><au>Kuang, Dajun</au><au>Jiang, Qing</au><au>Guo, Yingqiang</au><au>Wang, Yunbing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A versatile drug-controlled release polymer brush hybrid non-glutaraldehyde bioprosthetic heart valves with enhanced anti-inflammatory, anticoagulant and anti-calcification properties, and superior mechanical performance</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2023-05</date><risdate>2023</risdate><volume>296</volume><spage>122070</spage><epage>122070</epage><pages>122070-122070</pages><artnum>122070</artnum><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Transcatheter heart valve replacement (THVR) is a novel treatment modality for severe heart valves diseases and has become the main method for the treatment of heart valve diseases in recent years. However, the lifespan of the commercial glutaraldehyde cross-linked bioprosthetic heart valves (BHVs) used in THVR can only serve for 10–15 years, and the essential reason for the failure of the valve leaflet material is due to these problems such as calcification, coagulation, and inflammation caused by glutaraldehyde cross-linking. Herein, a kind of novel non-glutaraldehyde cross-linking agent bromo-bicyclic-oxazolidine (OX-Br) has been designed and synthesized with both crosslinking ability and in-situ atom transfer radical polymerization (ATRP) function. Then OX-Br treated porcine pericardium (OX-Br-PP) are stepwise modified with co-polymer brushes of reactive oxygen species (ROS) response anti-inflammatory drug conjugated block and anti-adhesion polyzwitterion polymer block through the in-situ ATRP reaction to obtain the functional BHV material MPQ@OX-PP. Along with the great mechanical properties and anti-enzymatic degradation ability similar to glutaraldehyde-crosslinked porcine pericardium (Glut-PP), good biocompatibility, improved anti-inflammatory effect, robust anti-coagulant ability and superior anti-calcification property have been verified for MPQ@OX-PP by a series of in vitro and in vivo investigations, indicating the excellent application potential as a multifunctional heart valve cross-linking agent for OX-Br. Meanwhile, the strategy of synergistic effect with in situ generations of reactive oxygen species-responsive anti-inflammatory drug blocks and anti-adhesion polymer brushes can effectively meet the requirement of multifaceted performance of bioprosthetic heart valves and provide a valuable reference for other blood contacting materials and functional implantable materials with great comprehensive performance.
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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2023-05, Vol.296, p.122070-122070, Article 122070 |
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| subjects | Animals Anti-calcification Anti-coagulant Anti-inflammatory Anti-Inflammatory Agents - metabolism Anticoagulants - pharmacology Bioprosthesis Calcinosis - metabolism Crosslinking Delayed-Action Preparations - metabolism Glutaral Heart Valve Prosthesis Heart Valves Pericardium - metabolism Polymers - metabolism Reactive Oxygen Species - metabolism Swine |
| title | A versatile drug-controlled release polymer brush hybrid non-glutaraldehyde bioprosthetic heart valves with enhanced anti-inflammatory, anticoagulant and anti-calcification properties, and superior mechanical performance |
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