Single nuclei transcriptomics delineates complex immune and kidney cell interactions contributing to kidney allograft fibrosis

Chronic allograft dysfunction (CAD), characterized histologically by interstitial fibrosis and tubular atrophy, is the major cause of kidney allograft loss. Here, using single nuclei RNA sequencing and transcriptome analysis, we identified the origin, functional heterogeneity, and regulation of fibr...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Kidney international 2023-06, Vol.103 (6), p.1077-1092
Hauptverfasser:	McDaniels, Jennifer M., Shetty, Amol C., Kuscu, Cem, Kuscu, Canan, Bardhi, Elissa, Rousselle, Thomas, Drachenberg, Cinthia, Talwar, Manish, Eason, James D., Muthukumar, Thangamani, Maluf, Daniel G., Mas, Valeria R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts - pathology chronic kidney injury Fibrosis fibrosis development Gene Expression Profiling Humans Kidney - pathology Kidney Diseases - pathology kidney transplantation Kidney Transplantation - adverse effects snRNA-seq Transcriptome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!