miR-194 Up-Regulates Cholesterol 7 Alpha-Hydroxylase Expression via β-Catenin Signaling and Aggravates Cholestatic Liver Diseases

miR-194 is abundantly expressed in hepatocytes, and its depletion increases hepatic resistance to acetaminophen-induced acute injuries. In this study, the biological role of miR-194 in cholestatic liver injury was investigated by using miR-194/miR-192 cluster liver-specific knockout (LKO) mice, in w...

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Veröffentlicht in:	The American journal of pathology 2023-06, Vol.193 (6), p.755-768
Hauptverfasser:	Chen, Po-Chun, Hsu, Chien-Peng, Wang, Sheng-Ya, Wu, Tsai-Yen, Lin, Yu-Jyun, Chen, You-Tzung, Hsu, Shu-Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Bile Acids and Salts - metabolism Cholestasis - genetics Cholestasis - metabolism Cholesterol - metabolism Hepatocytes - metabolism Liver Diseases - metabolism Mice
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