AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a complicated and refractory neurodegenerative disease that is typically characterized by memory loss and multiple cognitive impairments. Multiple neuropathology including hyperphosphorylated tau formation and accumulation, dysregulated mitochondrial dynamics, and sy...

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Veröffentlicht in:	Experimental neurology 2023-05, Vol.363, p.114355-114355, Article 114355
Hauptverfasser:	Wang, Cailin, Chang, Yanmin, Zhu, Jiahui, Wu, Yanqing, Jiang, Xingjun, Zheng, Siyi, Li, Gang, Ma, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	AdipoRon Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease AMP-Activated Protein Kinases - metabolism AMPK pathway Animals Disease Models, Animal Memory Disorders - pathology Mice Mice, Transgenic Mitochondrial Dynamics Neurodegenerative Diseases Tau pathology tau Proteins - metabolism Tauopathies - complications
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