Evaluation of expression of biomarkers of PLAGL1 (ZAC1), microRNA, and their non-coding RNAs in patients with endometriosis
Since the PLAGL1 (ZAC1) gene is expressed in the human endometrium. It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis....
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| Veröffentlicht in: | Journal of gynecology obstetrics and human reproduction 2023-04, Vol.52 (4), p.102568-102568, Article 102568 |
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| container_title | Journal of gynecology obstetrics and human reproduction |
| container_volume | 52 |
| creator | Tahermanesh, Kobra Hakimpour, Sahar Govahi, Azam Rokhgireh, Samaneh Mehdizadeh, Mehdi Minaeian, Sara Barati, Mahmood Chaichian, Shahla Kashi, Abolfazl Mehdizadeh Nassiri, Setare Eslahi, Neda Ajdary, Marziyeh Ahmadi, Maryam |
| description | Since the PLAGL1 (ZAC1) gene is expressed in the human endometrium. It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis. Blood plasma, ectopic (EC) and eutopic (EU) endometrial samples were gathered from 30 patients with endometriosis and 30 healthy fertile women, and the Q-PCR technique was used to determine the expression level of Zac1 mRNA and microRNAs (miR-1271–5p, hsa-miR-490–3pin) and LncRNAs (TONSL-AS1 TONSL, KCNQ1OT1 KCNQ1). According to the results, the Zac1 gene and KCNQ1OT1 KCNQ1, TONSL-AS1 TONSL LncRNA expression were significantly decreased in the endometriosis group versus the control group (P < 0.05). MiR-1271–5p and hsa-miR-490–3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group (P < 0.05). In summary, this research for the first time revealed that identifying Zac1 expression provides us with new indicators for evaluating endometriosis. |
| doi_str_mv | 10.1016/j.jogoh.2023.102568 |
| format | Article |
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It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis. Blood plasma, ectopic (EC) and eutopic (EU) endometrial samples were gathered from 30 patients with endometriosis and 30 healthy fertile women, and the Q-PCR technique was used to determine the expression level of Zac1 mRNA and microRNAs (miR-1271–5p, hsa-miR-490–3pin) and LncRNAs (TONSL-AS1 TONSL, KCNQ1OT1 KCNQ1). According to the results, the Zac1 gene and KCNQ1OT1 KCNQ1, TONSL-AS1 TONSL LncRNA expression were significantly decreased in the endometriosis group versus the control group (P < 0.05). MiR-1271–5p and hsa-miR-490–3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group (P < 0.05). In summary, this research for the first time revealed that identifying Zac1 expression provides us with new indicators for evaluating endometriosis.</description><identifier>ISSN: 2468-7847</identifier><identifier>EISSN: 2468-7847</identifier><identifier>DOI: 10.1016/j.jogoh.2023.102568</identifier><identifier>PMID: 36868502</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Biomarker ; Biomarkers ; Cell Cycle Proteins ; Endometriosis ; Endometriosis - genetics ; Endometriosis - metabolism ; Female ; Humans ; KCNQ1 Potassium Channel ; LncRNAs ; MicroRNA ; MicroRNAs - genetics ; NF-kappa B - metabolism ; PLAGL1 (Zac1) ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Transcription Factors ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Journal of gynecology obstetrics and human reproduction, 2023-04, Vol.52 (4), p.102568-102568, Article 102568</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Masson SAS.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-31b6ea865e271e84cf8eb780a1bf4b0491fa345453a4ece8694c8832c5b1b97c3</citedby><cites>FETCH-LOGICAL-c359t-31b6ea865e271e84cf8eb780a1bf4b0491fa345453a4ece8694c8832c5b1b97c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36868502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tahermanesh, Kobra</creatorcontrib><creatorcontrib>Hakimpour, Sahar</creatorcontrib><creatorcontrib>Govahi, Azam</creatorcontrib><creatorcontrib>Rokhgireh, Samaneh</creatorcontrib><creatorcontrib>Mehdizadeh, Mehdi</creatorcontrib><creatorcontrib>Minaeian, Sara</creatorcontrib><creatorcontrib>Barati, Mahmood</creatorcontrib><creatorcontrib>Chaichian, Shahla</creatorcontrib><creatorcontrib>Kashi, Abolfazl Mehdizadeh</creatorcontrib><creatorcontrib>Nassiri, Setare</creatorcontrib><creatorcontrib>Eslahi, Neda</creatorcontrib><creatorcontrib>Ajdary, Marziyeh</creatorcontrib><creatorcontrib>Ahmadi, Maryam</creatorcontrib><title>Evaluation of expression of biomarkers of PLAGL1 (ZAC1), microRNA, and their non-coding RNAs in patients with endometriosis</title><title>Journal of gynecology obstetrics and human reproduction</title><addtitle>J Gynecol Obstet Hum Reprod</addtitle><description>Since the PLAGL1 (ZAC1) gene is expressed in the human endometrium. It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis. Blood plasma, ectopic (EC) and eutopic (EU) endometrial samples were gathered from 30 patients with endometriosis and 30 healthy fertile women, and the Q-PCR technique was used to determine the expression level of Zac1 mRNA and microRNAs (miR-1271–5p, hsa-miR-490–3pin) and LncRNAs (TONSL-AS1 TONSL, KCNQ1OT1 KCNQ1). According to the results, the Zac1 gene and KCNQ1OT1 KCNQ1, TONSL-AS1 TONSL LncRNA expression were significantly decreased in the endometriosis group versus the control group (P < 0.05). MiR-1271–5p and hsa-miR-490–3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group (P < 0.05). In summary, this research for the first time revealed that identifying Zac1 expression provides us with new indicators for evaluating endometriosis.</description><subject>Biomarker</subject><subject>Biomarkers</subject><subject>Cell Cycle Proteins</subject><subject>Endometriosis</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>KCNQ1 Potassium Channel</subject><subject>LncRNAs</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>PLAGL1 (Zac1)</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Transcription Factors</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>2468-7847</issn><issn>2468-7847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhq0KVBDNL6hU-QgSm_prvd5DD1EEASmiqGovvVhe7yxxyNrB3kAr_nwdEipOnObrnXc0D0KfKRlTQuXX5XgZ7sJizAjjucNKqT6gYyakKiolqoM3-REapbQkhFDFpOTyIzriUklVEnaMni8ezWpjBhc8Dh2GP-sIKe2rxoXexHuIaVvdziezOcWnvydTenaOe2dj-HEzOcfGt3hYgIvYB1_Y0Dp_h_MkYefxOnuDHxJ-csMCg29DD0N0Ibn0CR12ZpVgtI8n6Nflxc_pVTH_PrueTuaF5WU9FJw2EoySJbCKghK2U9BUihjadKIhoqad4aIUJTcCLChZC6sUZ7ZsaFNXlp-g053vOoaHDaRB9y5ZWK2Mh7BJmlWKi5rJWmYp30nzbylF6PQ6uszgr6ZEb8HrpX4Br7fg9Q583vqyP7Bpemj_77xizoJvOwHkNx8dRJ1spmKhdRHsoNvg3j3wDy3QlEM</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Tahermanesh, Kobra</creator><creator>Hakimpour, Sahar</creator><creator>Govahi, Azam</creator><creator>Rokhgireh, Samaneh</creator><creator>Mehdizadeh, Mehdi</creator><creator>Minaeian, Sara</creator><creator>Barati, Mahmood</creator><creator>Chaichian, Shahla</creator><creator>Kashi, Abolfazl Mehdizadeh</creator><creator>Nassiri, Setare</creator><creator>Eslahi, Neda</creator><creator>Ajdary, Marziyeh</creator><creator>Ahmadi, Maryam</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202304</creationdate><title>Evaluation of expression of biomarkers of PLAGL1 (ZAC1), microRNA, and their non-coding RNAs in patients with endometriosis</title><author>Tahermanesh, Kobra ; Hakimpour, Sahar ; Govahi, Azam ; Rokhgireh, Samaneh ; Mehdizadeh, Mehdi ; Minaeian, Sara ; Barati, Mahmood ; Chaichian, Shahla ; Kashi, Abolfazl Mehdizadeh ; Nassiri, Setare ; Eslahi, Neda ; Ajdary, Marziyeh ; Ahmadi, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-31b6ea865e271e84cf8eb780a1bf4b0491fa345453a4ece8694c8832c5b1b97c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarker</topic><topic>Biomarkers</topic><topic>Cell Cycle Proteins</topic><topic>Endometriosis</topic><topic>Endometriosis - genetics</topic><topic>Endometriosis - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>KCNQ1 Potassium Channel</topic><topic>LncRNAs</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>NF-kappa B - metabolism</topic><topic>PLAGL1 (Zac1)</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Transcription Factors</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tahermanesh, Kobra</creatorcontrib><creatorcontrib>Hakimpour, Sahar</creatorcontrib><creatorcontrib>Govahi, Azam</creatorcontrib><creatorcontrib>Rokhgireh, Samaneh</creatorcontrib><creatorcontrib>Mehdizadeh, Mehdi</creatorcontrib><creatorcontrib>Minaeian, Sara</creatorcontrib><creatorcontrib>Barati, Mahmood</creatorcontrib><creatorcontrib>Chaichian, Shahla</creatorcontrib><creatorcontrib>Kashi, Abolfazl Mehdizadeh</creatorcontrib><creatorcontrib>Nassiri, Setare</creatorcontrib><creatorcontrib>Eslahi, Neda</creatorcontrib><creatorcontrib>Ajdary, Marziyeh</creatorcontrib><creatorcontrib>Ahmadi, Maryam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tahermanesh, Kobra</au><au>Hakimpour, Sahar</au><au>Govahi, Azam</au><au>Rokhgireh, Samaneh</au><au>Mehdizadeh, Mehdi</au><au>Minaeian, Sara</au><au>Barati, Mahmood</au><au>Chaichian, Shahla</au><au>Kashi, Abolfazl Mehdizadeh</au><au>Nassiri, Setare</au><au>Eslahi, Neda</au><au>Ajdary, Marziyeh</au><au>Ahmadi, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of expression of biomarkers of PLAGL1 (ZAC1), microRNA, and their non-coding RNAs in patients with endometriosis</atitle><jtitle>Journal of gynecology obstetrics and human reproduction</jtitle><addtitle>J Gynecol Obstet Hum Reprod</addtitle><date>2023-04</date><risdate>2023</risdate><volume>52</volume><issue>4</issue><spage>102568</spage><epage>102568</epage><pages>102568-102568</pages><artnum>102568</artnum><issn>2468-7847</issn><eissn>2468-7847</eissn><abstract>Since the PLAGL1 (ZAC1) gene is expressed in the human endometrium. It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis. Blood plasma, ectopic (EC) and eutopic (EU) endometrial samples were gathered from 30 patients with endometriosis and 30 healthy fertile women, and the Q-PCR technique was used to determine the expression level of Zac1 mRNA and microRNAs (miR-1271–5p, hsa-miR-490–3pin) and LncRNAs (TONSL-AS1 TONSL, KCNQ1OT1 KCNQ1). According to the results, the Zac1 gene and KCNQ1OT1 KCNQ1, TONSL-AS1 TONSL LncRNA expression were significantly decreased in the endometriosis group versus the control group (P < 0.05). MiR-1271–5p and hsa-miR-490–3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group (P < 0.05). In summary, this research for the first time revealed that identifying Zac1 expression provides us with new indicators for evaluating endometriosis.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>36868502</pmid><doi>10.1016/j.jogoh.2023.102568</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 2468-7847 |
| ispartof | Journal of gynecology obstetrics and human reproduction, 2023-04, Vol.52 (4), p.102568-102568, Article 102568 |
| issn | 2468-7847 2468-7847 |
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| subjects | Biomarker Biomarkers Cell Cycle Proteins Endometriosis Endometriosis - genetics Endometriosis - metabolism Female Humans KCNQ1 Potassium Channel LncRNAs MicroRNA MicroRNAs - genetics NF-kappa B - metabolism PLAGL1 (Zac1) RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcription Factors Tumor Suppressor Proteins - metabolism |
| title | Evaluation of expression of biomarkers of PLAGL1 (ZAC1), microRNA, and their non-coding RNAs in patients with endometriosis |
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