Regenerative potential of different extracellular vesicle subpopulations derived from clonal mesenchymal stem cells in a mouse model of chemotherapy-induced premature ovarian failure

Some studies have shown that mesenchymal stem cells (MSCs) and their derived extracellular vesicles (MSC-EVs) can restore ovarian function in premature ovarian failure (POF), however, concerns about their efficacy are attributed to the heterogeneity of the cell populations and EVs. Here, we assessed...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life sciences (1973) 2023-05, Vol.321, p.121536-121536, Article 121536
Hauptverfasser:	Eslami, Nasim, Bahrehbar, Khadijeh, Esfandiari, Fereshteh, Shekari, Faezeh, Hassani, Seyedeh-Nafiseh, Nazari, Abdoreza, Pakzad, Mohammad, Baharvand, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antineoplastic Agents - adverse effects Apoptosis body weight Clonal mesenchymal stromal cells (cMSCs) cost effectiveness cyclophosphamide Cyclophosphamide - adverse effects Extracellular vesicles (EVs) subpopulations Extracellular Vesicles - metabolism Female gene expression granulosa cells Humans interleukin-8 Mesenchymal Stem Cells - metabolism Mice Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT signaling pathway Premature ovarian failure (POF) Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - metabolism Primary Ovarian Insufficiency - therapy protein content therapeutics ultracentrifugation Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!