Layered plaque and plaque volume in patients with acute coronary syndromes
Background Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between l...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2023-04, Vol.55 (3), p.432-438 |
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| creator | Yuki, Haruhito Kinoshita, Daisuke Suzuki, Keishi Niida, Takayuki Nakajima, Akihiro Seegers, Lena Marie Vergallo, Rocco Fracassi, Francesco Russo, Michele Di Vito, Luca Bryniarski, Krzysztof McNulty, Iris Lee, Hang Kakuta, Tsunekazu Nakamura, Sunao Jang, Ik-Kyung |
| description | Background
Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between layered plaque and plaque volume has not been fully elucidated.
Methods
Patients who presented with acute coronary syndromes (ACS) and underwent pre-intervention optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of the culprit lesion were included. Layered plaque was identified by OCT, and plaque volume around the culprit lesion was measured by IVUS.
Results
Among 150 patients (52 with layered plaque; 98 non-layered plaque), total atheroma volume (183.3 mm
3
[114.2 mm
3
to 275.0 mm
3
] vs. 119.3 mm
3
[68.9 mm
3
to 185.5 mm
3
], p = 0.004), percent atheroma volume (PAV) (60.1%[54.7–60.1%] vs. 53.7%[46.8–60.6%], p = 0.001), and plaque burden (86.5%[81.7–85.7%] vs. 82.6%[77.9–85.4%], p = 0.001) were significantly greater in patients with layered plaques than in those with non-layered plaques. When layered plaques were divided into multi-layered or single-layered plaques, PAV was significantly greater in patients with multi-layered plaques than in those with single-layered plaques (62.1%[56.8–67.8%] vs. 57.5%[48.9–60.1%], p = 0.017). Layered plaques, compared to those with non-layered pattern, had larger lipid index (1958.0[420.9 to 2502.9] vs. 597.2[169.1 to 1624.7], p = 0.014).
Conclusion
Layered plaques, compared to non-layered plaques, had significantly greater plaque volume and lipid index. These results indicate that plaque disruption and the subsequent healing process significantly contribute to plaque progression at the culprit lesion in patients with ACS.
Clinical Trial Registration
http://www.clinicaltrials.gov
, NCT01110538, NCT03479723, UMIN000041692. |
| doi_str_mv | 10.1007/s11239-023-02788-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2783490868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2802188069</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-6b256a2c7d28a492b15feffc5d43298a70abe84affe1e2f0a73813fcf96b542f3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuXaj7aJjnK4icLXhS8hbSdaJc2rUmr7L83a9dVPHgIGcgz70wehI4JPicY8wtPCGUyxpSFw4WI5Q6akpSzmCf0efdXPUEH3i8xxlJiuo8mLBOZFFxM0f1Cr8BBGXW1fhsg0nZbvrf10EBU2ajTfQW299FH1b9Guhh6iIrWtVa7VeRXtnRtA_4Q7Rldezja3DP0dH31OL-NFw83d_PLRVwwnvZxltM007TgJRU6kTQnqQFjirRMGJVCc6xzEIk2BghQgzVngjBTGJnlaUINm6GzMbdzbdjT96qpfAF1rS20g1dBBUskFpkI6OkfdNkOzobtFBWYEiFwJgNFR6pwrfcOjOpc1YS_KYLV2rQaTatgWn2ZVuumk030kDdQblu-1QaAjYAPT_YF3M_sf2I_AUzJidI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2802188069</pqid></control><display><type>article</type><title>Layered plaque and plaque volume in patients with acute coronary syndromes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yuki, Haruhito ; Kinoshita, Daisuke ; Suzuki, Keishi ; Niida, Takayuki ; Nakajima, Akihiro ; Seegers, Lena Marie ; Vergallo, Rocco ; Fracassi, Francesco ; Russo, Michele ; Di Vito, Luca ; Bryniarski, Krzysztof ; McNulty, Iris ; Lee, Hang ; Kakuta, Tsunekazu ; Nakamura, Sunao ; Jang, Ik-Kyung</creator><creatorcontrib>Yuki, Haruhito ; Kinoshita, Daisuke ; Suzuki, Keishi ; Niida, Takayuki ; Nakajima, Akihiro ; Seegers, Lena Marie ; Vergallo, Rocco ; Fracassi, Francesco ; Russo, Michele ; Di Vito, Luca ; Bryniarski, Krzysztof ; McNulty, Iris ; Lee, Hang ; Kakuta, Tsunekazu ; Nakamura, Sunao ; Jang, Ik-Kyung</creatorcontrib><description>Background
Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between layered plaque and plaque volume has not been fully elucidated.
Methods
Patients who presented with acute coronary syndromes (ACS) and underwent pre-intervention optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of the culprit lesion were included. Layered plaque was identified by OCT, and plaque volume around the culprit lesion was measured by IVUS.
Results
Among 150 patients (52 with layered plaque; 98 non-layered plaque), total atheroma volume (183.3 mm
3
[114.2 mm
3
to 275.0 mm
3
] vs. 119.3 mm
3
[68.9 mm
3
to 185.5 mm
3
], p = 0.004), percent atheroma volume (PAV) (60.1%[54.7–60.1%] vs. 53.7%[46.8–60.6%], p = 0.001), and plaque burden (86.5%[81.7–85.7%] vs. 82.6%[77.9–85.4%], p = 0.001) were significantly greater in patients with layered plaques than in those with non-layered plaques. When layered plaques were divided into multi-layered or single-layered plaques, PAV was significantly greater in patients with multi-layered plaques than in those with single-layered plaques (62.1%[56.8–67.8%] vs. 57.5%[48.9–60.1%], p = 0.017). Layered plaques, compared to those with non-layered pattern, had larger lipid index (1958.0[420.9 to 2502.9] vs. 597.2[169.1 to 1624.7], p = 0.014).
Conclusion
Layered plaques, compared to non-layered plaques, had significantly greater plaque volume and lipid index. These results indicate that plaque disruption and the subsequent healing process significantly contribute to plaque progression at the culprit lesion in patients with ACS.
Clinical Trial Registration
http://www.clinicaltrials.gov
, NCT01110538, NCT03479723, UMIN000041692.</description><identifier>ISSN: 1573-742X</identifier><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-023-02788-9</identifier><identifier>PMID: 36869878</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute Coronary Syndrome - diagnostic imaging ; Acute Coronary Syndrome - pathology ; Acute coronary syndromes ; Cardiology ; Coronary Angiography ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Hematology ; Humans ; Lesions ; Lipids ; Medicine ; Medicine & Public Health ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - pathology ; Plaques ; Thrombosis ; Tomography, Optical Coherence - methods ; Ultrasonography, Interventional - methods</subject><ispartof>Journal of thrombosis and thrombolysis, 2023-04, Vol.55 (3), p.432-438</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6b256a2c7d28a492b15feffc5d43298a70abe84affe1e2f0a73813fcf96b542f3</citedby><cites>FETCH-LOGICAL-c375t-6b256a2c7d28a492b15feffc5d43298a70abe84affe1e2f0a73813fcf96b542f3</cites><orcidid>0000-0002-5796-3006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-023-02788-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-023-02788-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36869878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuki, Haruhito</creatorcontrib><creatorcontrib>Kinoshita, Daisuke</creatorcontrib><creatorcontrib>Suzuki, Keishi</creatorcontrib><creatorcontrib>Niida, Takayuki</creatorcontrib><creatorcontrib>Nakajima, Akihiro</creatorcontrib><creatorcontrib>Seegers, Lena Marie</creatorcontrib><creatorcontrib>Vergallo, Rocco</creatorcontrib><creatorcontrib>Fracassi, Francesco</creatorcontrib><creatorcontrib>Russo, Michele</creatorcontrib><creatorcontrib>Di Vito, Luca</creatorcontrib><creatorcontrib>Bryniarski, Krzysztof</creatorcontrib><creatorcontrib>McNulty, Iris</creatorcontrib><creatorcontrib>Lee, Hang</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><creatorcontrib>Jang, Ik-Kyung</creatorcontrib><title>Layered plaque and plaque volume in patients with acute coronary syndromes</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>Background
Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between layered plaque and plaque volume has not been fully elucidated.
Methods
Patients who presented with acute coronary syndromes (ACS) and underwent pre-intervention optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of the culprit lesion were included. Layered plaque was identified by OCT, and plaque volume around the culprit lesion was measured by IVUS.
Results
Among 150 patients (52 with layered plaque; 98 non-layered plaque), total atheroma volume (183.3 mm
3
[114.2 mm
3
to 275.0 mm
3
] vs. 119.3 mm
3
[68.9 mm
3
to 185.5 mm
3
], p = 0.004), percent atheroma volume (PAV) (60.1%[54.7–60.1%] vs. 53.7%[46.8–60.6%], p = 0.001), and plaque burden (86.5%[81.7–85.7%] vs. 82.6%[77.9–85.4%], p = 0.001) were significantly greater in patients with layered plaques than in those with non-layered plaques. When layered plaques were divided into multi-layered or single-layered plaques, PAV was significantly greater in patients with multi-layered plaques than in those with single-layered plaques (62.1%[56.8–67.8%] vs. 57.5%[48.9–60.1%], p = 0.017). Layered plaques, compared to those with non-layered pattern, had larger lipid index (1958.0[420.9 to 2502.9] vs. 597.2[169.1 to 1624.7], p = 0.014).
Conclusion
Layered plaques, compared to non-layered plaques, had significantly greater plaque volume and lipid index. These results indicate that plaque disruption and the subsequent healing process significantly contribute to plaque progression at the culprit lesion in patients with ACS.
Clinical Trial Registration
http://www.clinicaltrials.gov
, NCT01110538, NCT03479723, UMIN000041692.</description><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Acute Coronary Syndrome - pathology</subject><subject>Acute coronary syndromes</subject><subject>Cardiology</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - pathology</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lesions</subject><subject>Lipids</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Plaques</subject><subject>Thrombosis</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Ultrasonography, Interventional - methods</subject><issn>1573-742X</issn><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuXaj7aJjnK4icLXhS8hbSdaJc2rUmr7L83a9dVPHgIGcgz70wehI4JPicY8wtPCGUyxpSFw4WI5Q6akpSzmCf0efdXPUEH3i8xxlJiuo8mLBOZFFxM0f1Cr8BBGXW1fhsg0nZbvrf10EBU2ajTfQW299FH1b9Guhh6iIrWtVa7VeRXtnRtA_4Q7Rldezja3DP0dH31OL-NFw83d_PLRVwwnvZxltM007TgJRU6kTQnqQFjirRMGJVCc6xzEIk2BghQgzVngjBTGJnlaUINm6GzMbdzbdjT96qpfAF1rS20g1dBBUskFpkI6OkfdNkOzobtFBWYEiFwJgNFR6pwrfcOjOpc1YS_KYLV2rQaTatgWn2ZVuumk030kDdQblu-1QaAjYAPT_YF3M_sf2I_AUzJidI</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Yuki, Haruhito</creator><creator>Kinoshita, Daisuke</creator><creator>Suzuki, Keishi</creator><creator>Niida, Takayuki</creator><creator>Nakajima, Akihiro</creator><creator>Seegers, Lena Marie</creator><creator>Vergallo, Rocco</creator><creator>Fracassi, Francesco</creator><creator>Russo, Michele</creator><creator>Di Vito, Luca</creator><creator>Bryniarski, Krzysztof</creator><creator>McNulty, Iris</creator><creator>Lee, Hang</creator><creator>Kakuta, Tsunekazu</creator><creator>Nakamura, Sunao</creator><creator>Jang, Ik-Kyung</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5796-3006</orcidid></search><sort><creationdate>20230401</creationdate><title>Layered plaque and plaque volume in patients with acute coronary syndromes</title><author>Yuki, Haruhito ; Kinoshita, Daisuke ; Suzuki, Keishi ; Niida, Takayuki ; Nakajima, Akihiro ; Seegers, Lena Marie ; Vergallo, Rocco ; Fracassi, Francesco ; Russo, Michele ; Di Vito, Luca ; Bryniarski, Krzysztof ; McNulty, Iris ; Lee, Hang ; Kakuta, Tsunekazu ; Nakamura, Sunao ; Jang, Ik-Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6b256a2c7d28a492b15feffc5d43298a70abe84affe1e2f0a73813fcf96b542f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Acute Coronary Syndrome - pathology</topic><topic>Acute coronary syndromes</topic><topic>Cardiology</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - pathology</topic><topic>Hematology</topic><topic>Humans</topic><topic>Lesions</topic><topic>Lipids</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Plaques</topic><topic>Thrombosis</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Ultrasonography, Interventional - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuki, Haruhito</creatorcontrib><creatorcontrib>Kinoshita, Daisuke</creatorcontrib><creatorcontrib>Suzuki, Keishi</creatorcontrib><creatorcontrib>Niida, Takayuki</creatorcontrib><creatorcontrib>Nakajima, Akihiro</creatorcontrib><creatorcontrib>Seegers, Lena Marie</creatorcontrib><creatorcontrib>Vergallo, Rocco</creatorcontrib><creatorcontrib>Fracassi, Francesco</creatorcontrib><creatorcontrib>Russo, Michele</creatorcontrib><creatorcontrib>Di Vito, Luca</creatorcontrib><creatorcontrib>Bryniarski, Krzysztof</creatorcontrib><creatorcontrib>McNulty, Iris</creatorcontrib><creatorcontrib>Lee, Hang</creatorcontrib><creatorcontrib>Kakuta, Tsunekazu</creatorcontrib><creatorcontrib>Nakamura, Sunao</creatorcontrib><creatorcontrib>Jang, Ik-Kyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuki, Haruhito</au><au>Kinoshita, Daisuke</au><au>Suzuki, Keishi</au><au>Niida, Takayuki</au><au>Nakajima, Akihiro</au><au>Seegers, Lena Marie</au><au>Vergallo, Rocco</au><au>Fracassi, Francesco</au><au>Russo, Michele</au><au>Di Vito, Luca</au><au>Bryniarski, Krzysztof</au><au>McNulty, Iris</au><au>Lee, Hang</au><au>Kakuta, Tsunekazu</au><au>Nakamura, Sunao</au><au>Jang, Ik-Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Layered plaque and plaque volume in patients with acute coronary syndromes</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>55</volume><issue>3</issue><spage>432</spage><epage>438</epage><pages>432-438</pages><issn>1573-742X</issn><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Background
Layered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between layered plaque and plaque volume has not been fully elucidated.
Methods
Patients who presented with acute coronary syndromes (ACS) and underwent pre-intervention optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of the culprit lesion were included. Layered plaque was identified by OCT, and plaque volume around the culprit lesion was measured by IVUS.
Results
Among 150 patients (52 with layered plaque; 98 non-layered plaque), total atheroma volume (183.3 mm
3
[114.2 mm
3
to 275.0 mm
3
] vs. 119.3 mm
3
[68.9 mm
3
to 185.5 mm
3
], p = 0.004), percent atheroma volume (PAV) (60.1%[54.7–60.1%] vs. 53.7%[46.8–60.6%], p = 0.001), and plaque burden (86.5%[81.7–85.7%] vs. 82.6%[77.9–85.4%], p = 0.001) were significantly greater in patients with layered plaques than in those with non-layered plaques. When layered plaques were divided into multi-layered or single-layered plaques, PAV was significantly greater in patients with multi-layered plaques than in those with single-layered plaques (62.1%[56.8–67.8%] vs. 57.5%[48.9–60.1%], p = 0.017). Layered plaques, compared to those with non-layered pattern, had larger lipid index (1958.0[420.9 to 2502.9] vs. 597.2[169.1 to 1624.7], p = 0.014).
Conclusion
Layered plaques, compared to non-layered plaques, had significantly greater plaque volume and lipid index. These results indicate that plaque disruption and the subsequent healing process significantly contribute to plaque progression at the culprit lesion in patients with ACS.
Clinical Trial Registration
http://www.clinicaltrials.gov
, NCT01110538, NCT03479723, UMIN000041692.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36869878</pmid><doi>10.1007/s11239-023-02788-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5796-3006</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1573-742X |
| ispartof | Journal of thrombosis and thrombolysis, 2023-04, Vol.55 (3), p.432-438 |
| issn | 1573-742X 0929-5305 1573-742X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Coronary Syndrome - diagnostic imaging Acute Coronary Syndrome - pathology Acute coronary syndromes Cardiology Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - pathology Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Hematology Humans Lesions Lipids Medicine Medicine & Public Health Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - pathology Plaques Thrombosis Tomography, Optical Coherence - methods Ultrasonography, Interventional - methods |
| title | Layered plaque and plaque volume in patients with acute coronary syndromes |
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