Trifluoromethyl Vinamidinium Salt as a Promising Precursor for Fused β‑Trifluoromethyl Pyridines
An efficient chlorotrimethylsilane-promoted synthetic protocol for the preparation of functionalized fused β-trifluoromethyl pyridines by cyclization of electron-rich aminoheterocycles or substituted anilines with a trifluoromethyl vinamidinium salt was developed. The efficient and scalable approach...
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| Veröffentlicht in: | Journal of organic chemistry 2023-03, Vol.88 (5), p.2961-2972 |
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| container_end_page | 2972 |
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| container_title | Journal of organic chemistry |
| container_volume | 88 |
| creator | Mityuk, Andrii P. Kiriakov, Oleksandr M. Tiutiunnyk, Vladislav V. Lebed, Pavlo S. Grabchuk, Galyna P. Rusanov, Eduard B. Volochnyuk, Dmitriy M. Ryabukhin, Sergey V. |
| description | An efficient chlorotrimethylsilane-promoted synthetic protocol for the preparation of functionalized fused β-trifluoromethyl pyridines by cyclization of electron-rich aminoheterocycles or substituted anilines with a trifluoromethyl vinamidinium salt was developed. The efficient and scalable approach for producing represented trifluoromethyl vinamidinium salt demonstrated huge prospects for further use. The structure specificities of the trifluoromethyl vinamidinium salt and their impact on the reaction progress were determined. The procedure’s scope and alternative ways of the reaction were investigated. The possibility of increasing the reaction scale up to 50 g and further modification of obtained products was shown. A minilibrary of potential fragments for 19F NMR-based fragment-based drug discovery (FBDD) was synthesized. |
| doi_str_mv | 10.1021/acs.joc.2c02684 |
| format | Article |
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The efficient and scalable approach for producing represented trifluoromethyl vinamidinium salt demonstrated huge prospects for further use. The structure specificities of the trifluoromethyl vinamidinium salt and their impact on the reaction progress were determined. The procedure’s scope and alternative ways of the reaction were investigated. The possibility of increasing the reaction scale up to 50 g and further modification of obtained products was shown. 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| ispartof | Journal of organic chemistry, 2023-03, Vol.88 (5), p.2961-2972 |
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| language | eng |
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| source | American Chemical Society Journals |
| title | Trifluoromethyl Vinamidinium Salt as a Promising Precursor for Fused β‑Trifluoromethyl Pyridines |
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