Therapeutic Drug Monitoring of Blood Sirolimus and Tacrolimus Concentrations for Polypharmacy Management in a Lymphangioleiomyomatosis Patient Taking Two Cytochrome P450 3A Inhibitors

Patients with lymphangioleiomyomatosis (LAM) and lung transplantations are treated with multiple drugs, such as tacrolimus, mycophenolate mofetil, prednisolone, and itraconazole, for long-term suppression of rejection response and prevention of infection. Additional drugs are required when lung tran...

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Veröffentlicht in:	The Tohoku Journal of Experimental Medicine 2023, Vol.260(1), pp.29-34
Hauptverfasser:	Kumondai, Masaki, Kikuchi, Masafumi, Mizuguchi, Atsushi, Hayashi, Nagomi, Ui, Masahiro, Hirama, Takashi, Okada, Yoshinori, Sato, Yu, Sato, Toshihiro, Maekawa, Masamitsu, Mano, Nariyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Clarithromycin Cytochrome P-450 CYP3A - genetics cytochrome P450 3A Drug Monitoring drug–drug interactions Female Humans Immunosuppressive Agents - therapeutic use Itraconazole lung transplantation lymphangioleiomyomatosis Lymphangioleiomyomatosis - chemically induced Lymphangioleiomyomatosis - drug therapy Middle Aged Mycophenolic Acid - adverse effects Polypharmacy Prednisolone Sirolimus - adverse effects Tacrolimus - therapeutic use therapeutic drug monitoring
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