Antibiotic-induced degradation of antitoxin enhances the transcription of acetyltransferase-type toxin-antitoxin operon

Abstract Background Bacterial toxin-antitoxin (TA) modules respond to various stressful conditions. The Gcn5-related N-acetyltransferase-type toxin (GNAT) protein encoded by the GNAT-RHH TA locus is involved in the antibiotic tolerance of Klebsiella pneumoniae. Objectives To investigate the transcri...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2023-04, Vol.78 (4), p.1066-1075
Hauptverfasser:	Li, Peifei, Goh, Ying-Xian, Ilic, Bojana, Tai, Cui, Deng, Zixin, Chen, Zhaoyan, Djordjevic, Marko, Ou, Hong-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases Anti-Bacterial Agents - pharmacology Antitoxins - genetics Bacterial Proteins - genetics Bacterial Proteins - metabolism Gene Expression Regulation, Bacterial Meropenem Operon Protease La - metabolism
Online-Zugang:	Volltext
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