Amygdala substructure volumes and serotonin transporter in first-episode, drug- naïve major depressive disorder: A pilot study
Amygdala and serotonergic system abnormalities have been documented in major depressive disorder (MDD). However, most studies have been conducted on recurrent MDD, and only a few have assessed their interaction. This study aimed to concurrently examine both the amygdala and serotonergic systems and...
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| Veröffentlicht in: | Journal of psychiatric research 2023-04, Vol.160, p.210-216 |
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| creator | Chen, Ching-Wen Chou, Yuan-Hwa Liou, Ying-Jay Yang, Kai-Chun Hu, Li-Yu Hsieh, Wen-Chi Liu, Mu-N |
| description | Amygdala and serotonergic system abnormalities have been documented in major depressive disorder (MDD). However, most studies have been conducted on recurrent MDD, and only a few have assessed their interaction. This study aimed to concurrently examine both the amygdala and serotonergic systems and their clinical relevance in first-episode, drug-naïve MDD.
This study included 27 patients with first-episode, drug-naïve MDD and 27 age- and gender-matched healthy controls (HCs). The amygdala substructure volumes were performed with Freesurfer from a 1.5 T magnetic resonance image. Serotonin transporter (SERT) availability was detected by single-photon emission computed tomography with 123I-ADAM. The Benjamini-Hochberg method was applied to adjust for multiple comparisons.
No significant difference was found in the amygdala substructure volume and SERT availability between the two groups, respectively. Within MDD patients, the right medial, cortical nucleus, and centromedial volumes were positively associated with caudate SERT availability, respectively. Moreover, the right lateral nucleus volume in the amygdala was positively correlated with depression severity. However, these significances did not survive correction for multiple testing.
There were no significant abnormalities in the amygdala substructure volumes and SERT availability in patients with first-episode, drug-naïve MDD. We did not observe an association between amygdala substructure volume and serotonergic dysregulation and their correlations with depression severity in patients with MDD. A larger sample size is warranted to elucidate the actual correlation.
•The MDD group vs. controls showed no significant differences in the amygdala substructure volumes and SERT availability.•Amygdala substructure volumes were not associated with SERT availability in patients with MDD.•Neither amygdala nucleus volume nor SERT availability was associated with depression severity in MDD patients. |
| doi_str_mv | 10.1016/j.jpsychires.2023.02.015 |
| format | Article |
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This study included 27 patients with first-episode, drug-naïve MDD and 27 age- and gender-matched healthy controls (HCs). The amygdala substructure volumes were performed with Freesurfer from a 1.5 T magnetic resonance image. Serotonin transporter (SERT) availability was detected by single-photon emission computed tomography with 123I-ADAM. The Benjamini-Hochberg method was applied to adjust for multiple comparisons.
No significant difference was found in the amygdala substructure volume and SERT availability between the two groups, respectively. Within MDD patients, the right medial, cortical nucleus, and centromedial volumes were positively associated with caudate SERT availability, respectively. Moreover, the right lateral nucleus volume in the amygdala was positively correlated with depression severity. However, these significances did not survive correction for multiple testing.
There were no significant abnormalities in the amygdala substructure volumes and SERT availability in patients with first-episode, drug-naïve MDD. We did not observe an association between amygdala substructure volume and serotonergic dysregulation and their correlations with depression severity in patients with MDD. A larger sample size is warranted to elucidate the actual correlation.
•The MDD group vs. controls showed no significant differences in the amygdala substructure volumes and SERT availability.•Amygdala substructure volumes were not associated with SERT availability in patients with MDD.•Neither amygdala nucleus volume nor SERT availability was associated with depression severity in MDD patients.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2023.02.015</identifier><identifier>PMID: 36857985</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>123I- ADAM ; Amygdala ; Amygdala - metabolism ; Depressive Disorder, Major ; Freesurfer ; Humans ; Magnetic Resonance Imaging ; Major depressive disorder ; Pilot Projects ; Serotonin Plasma Membrane Transport Proteins - metabolism ; Serotonin transporter ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of psychiatric research, 2023-04, Vol.160, p.210-216</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c234t-ab0a474c6b2b5e3fc0fd7d3da2a25dc6e2bbb4e741f0da6406a4d406509bee8e3</cites><orcidid>0000-0003-0841-8834 ; 0000-0002-3792-3971 ; 0000-0001-8198-2509</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2023.02.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36857985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ching-Wen</creatorcontrib><creatorcontrib>Chou, Yuan-Hwa</creatorcontrib><creatorcontrib>Liou, Ying-Jay</creatorcontrib><creatorcontrib>Yang, Kai-Chun</creatorcontrib><creatorcontrib>Hu, Li-Yu</creatorcontrib><creatorcontrib>Hsieh, Wen-Chi</creatorcontrib><creatorcontrib>Liu, Mu-N</creatorcontrib><title>Amygdala substructure volumes and serotonin transporter in first-episode, drug- naïve major depressive disorder: A pilot study</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Amygdala and serotonergic system abnormalities have been documented in major depressive disorder (MDD). However, most studies have been conducted on recurrent MDD, and only a few have assessed their interaction. This study aimed to concurrently examine both the amygdala and serotonergic systems and their clinical relevance in first-episode, drug-naïve MDD.
This study included 27 patients with first-episode, drug-naïve MDD and 27 age- and gender-matched healthy controls (HCs). The amygdala substructure volumes were performed with Freesurfer from a 1.5 T magnetic resonance image. Serotonin transporter (SERT) availability was detected by single-photon emission computed tomography with 123I-ADAM. The Benjamini-Hochberg method was applied to adjust for multiple comparisons.
No significant difference was found in the amygdala substructure volume and SERT availability between the two groups, respectively. Within MDD patients, the right medial, cortical nucleus, and centromedial volumes were positively associated with caudate SERT availability, respectively. Moreover, the right lateral nucleus volume in the amygdala was positively correlated with depression severity. However, these significances did not survive correction for multiple testing.
There were no significant abnormalities in the amygdala substructure volumes and SERT availability in patients with first-episode, drug-naïve MDD. We did not observe an association between amygdala substructure volume and serotonergic dysregulation and their correlations with depression severity in patients with MDD. A larger sample size is warranted to elucidate the actual correlation.
•The MDD group vs. controls showed no significant differences in the amygdala substructure volumes and SERT availability.•Amygdala substructure volumes were not associated with SERT availability in patients with MDD.•Neither amygdala nucleus volume nor SERT availability was associated with depression severity in MDD patients.</description><subject>123I- ADAM</subject><subject>Amygdala</subject><subject>Amygdala - metabolism</subject><subject>Depressive Disorder, Major</subject><subject>Freesurfer</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Major depressive disorder</subject><subject>Pilot Projects</subject><subject>Serotonin Plasma Membrane Transport Proteins - metabolism</subject><subject>Serotonin transporter</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi0EotvCKyAfOZBgO7GTcFuqQpEqcSlny7EnxVESB4-z0p76SDxEX6yutsCRiy2Pvpl__BFCOSs54-rjWI4rHu1PHwFLwURVMlEyLl-QHW-bruBV070kO8aEKKpOqjNyjjgyxhrB69fkrFKtbLpW7sj9fj7eOTMZiluPKW42bRHoIUzbDEjN4ihCDCksfqEpmgXXEBNEmp-Dj5gKWD0GBx-oi9tdQRfz8PsAdDZjiNTBmjdEnwsuU9FB_ET3dPVTSBTT5o5vyKvBTAhvn-8L8uPL1e3ldXHz_eu3y_1NYUVVp8L0zNRNbVUvegnVYNngGlc5I4yQzioQfd_X0NR8YM6omilTu3xK1vUALVQX5P1p7hrDrw0w6dmjhWkyC4QNtWhargSTUmW0PaE2BsQIg16jn008as70k3496n_69ZN-zYTO-nPru-eUrZ_B_W384zsDn08A5L8ePESN1sNiweVZNmkX_P9THgEk16Dr</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Chen, Ching-Wen</creator><creator>Chou, Yuan-Hwa</creator><creator>Liou, Ying-Jay</creator><creator>Yang, Kai-Chun</creator><creator>Hu, Li-Yu</creator><creator>Hsieh, Wen-Chi</creator><creator>Liu, Mu-N</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0841-8834</orcidid><orcidid>https://orcid.org/0000-0002-3792-3971</orcidid><orcidid>https://orcid.org/0000-0001-8198-2509</orcidid></search><sort><creationdate>202304</creationdate><title>Amygdala substructure volumes and serotonin transporter in first-episode, drug- naïve major depressive disorder: A pilot study</title><author>Chen, Ching-Wen ; Chou, Yuan-Hwa ; Liou, Ying-Jay ; Yang, Kai-Chun ; Hu, Li-Yu ; Hsieh, Wen-Chi ; Liu, Mu-N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c234t-ab0a474c6b2b5e3fc0fd7d3da2a25dc6e2bbb4e741f0da6406a4d406509bee8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>123I- ADAM</topic><topic>Amygdala</topic><topic>Amygdala - metabolism</topic><topic>Depressive Disorder, Major</topic><topic>Freesurfer</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Major depressive disorder</topic><topic>Pilot Projects</topic><topic>Serotonin Plasma Membrane Transport Proteins - metabolism</topic><topic>Serotonin transporter</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ching-Wen</creatorcontrib><creatorcontrib>Chou, Yuan-Hwa</creatorcontrib><creatorcontrib>Liou, Ying-Jay</creatorcontrib><creatorcontrib>Yang, Kai-Chun</creatorcontrib><creatorcontrib>Hu, Li-Yu</creatorcontrib><creatorcontrib>Hsieh, Wen-Chi</creatorcontrib><creatorcontrib>Liu, Mu-N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ching-Wen</au><au>Chou, Yuan-Hwa</au><au>Liou, Ying-Jay</au><au>Yang, Kai-Chun</au><au>Hu, Li-Yu</au><au>Hsieh, Wen-Chi</au><au>Liu, Mu-N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amygdala substructure volumes and serotonin transporter in first-episode, drug- naïve major depressive disorder: A pilot study</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2023-04</date><risdate>2023</risdate><volume>160</volume><spage>210</spage><epage>216</epage><pages>210-216</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Amygdala and serotonergic system abnormalities have been documented in major depressive disorder (MDD). However, most studies have been conducted on recurrent MDD, and only a few have assessed their interaction. This study aimed to concurrently examine both the amygdala and serotonergic systems and their clinical relevance in first-episode, drug-naïve MDD.
This study included 27 patients with first-episode, drug-naïve MDD and 27 age- and gender-matched healthy controls (HCs). The amygdala substructure volumes were performed with Freesurfer from a 1.5 T magnetic resonance image. Serotonin transporter (SERT) availability was detected by single-photon emission computed tomography with 123I-ADAM. The Benjamini-Hochberg method was applied to adjust for multiple comparisons.
No significant difference was found in the amygdala substructure volume and SERT availability between the two groups, respectively. Within MDD patients, the right medial, cortical nucleus, and centromedial volumes were positively associated with caudate SERT availability, respectively. Moreover, the right lateral nucleus volume in the amygdala was positively correlated with depression severity. However, these significances did not survive correction for multiple testing.
There were no significant abnormalities in the amygdala substructure volumes and SERT availability in patients with first-episode, drug-naïve MDD. We did not observe an association between amygdala substructure volume and serotonergic dysregulation and their correlations with depression severity in patients with MDD. A larger sample size is warranted to elucidate the actual correlation.
•The MDD group vs. controls showed no significant differences in the amygdala substructure volumes and SERT availability.•Amygdala substructure volumes were not associated with SERT availability in patients with MDD.•Neither amygdala nucleus volume nor SERT availability was associated with depression severity in MDD patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36857985</pmid><doi>10.1016/j.jpsychires.2023.02.015</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0841-8834</orcidid><orcidid>https://orcid.org/0000-0002-3792-3971</orcidid><orcidid>https://orcid.org/0000-0001-8198-2509</orcidid></addata></record> |
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| subjects | 123I- ADAM Amygdala Amygdala - metabolism Depressive Disorder, Major Freesurfer Humans Magnetic Resonance Imaging Major depressive disorder Pilot Projects Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin transporter Tomography, Emission-Computed, Single-Photon |
| title | Amygdala substructure volumes and serotonin transporter in first-episode, drug- naïve major depressive disorder: A pilot study |
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