Intraperitoneal injection of iron dextran induces peripheral iron overload and mild neurodegeneration in the nigrostriatal system in C57BL/6 mice

Elevated iron levels in the affected areas of brain are linked to several neurodegenerative diseases including Parkinson's disease (PD). This study investigated the influence of peripheral iron overload in peripheral tissues, as well as its entry into the brain regions on lysosomal functions. T...

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Veröffentlicht in:	Life sciences (1973) 2023-05, Vol.320, p.121508-121508, Article 121508
Hauptverfasser:	Liang, Meiyu, Chen, Lei, He, Qing, Mi, Xiaoqing, Qu, Le, Xie, Junxia, Song, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Cerebrospinal fluid Dextrans - metabolism Dopaminergic neurons Dopaminergic Neurons - metabolism Injections, Intraperitoneal Iron Iron - metabolism Iron Overload - chemically induced Iron Overload - metabolism Iron-Dextran Complex - metabolism Iron-Dextran Complex - toxicity Lysosomal dysfunction Mice Mice, Inbred C57BL Serum Substantia Nigra - metabolism
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