Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force

[Display omitted] The armeniaspirol family of natural product antibiotics have been shown to inhibit the ATP-dependent proteases ClpXP and ClpYQ and disrupt membrane potential through shuttling of protons across the membrane. Herein we investigate their ability to disrupt the proton motive force (PM...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-03, Vol.84, p.129210-129210, Article 129210
Hauptverfasser:	Darnowski, Michael G., Lanosky, Taylor D., Paquette, André R., Boddy, Christopher N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Proton-Motive Force Protons Thylakoids - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!