Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101)

Objective CD28 and inducible T cell costimulator (ICOS) appear to have nonredundant roles in T cell activation and adaptive immunity. We undertook this study to characterize in vitro and in vivo the therapeutic potential of acazicolcept (ALPN‐101), an Fc fusion protein of a human variant ICOS ligand...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2023-08, Vol.75 (8), p.1344-1356
Hauptverfasser:	Dillon, Stacey R., Evans, Lawrence S., Lewis, Katherine E., Debrot, Susan, Blair, Tiffany C., Mudri, Sherri, Kleist, Kayla, Levin, Steven D., Bhandari, Janhavi G., Garrett, Logan, Wolfson, Martin F., Holland, Pamela M., Rixon, Mark W., Peng, Stanford L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Antigen-presenting cells Antigens Arthritis Binding CD28 antigen Cell activation Cytokines Fc receptors Fusion protein Gene expression In vivo methods and tests Inflammation Inhibitors Leukocytes (mononuclear) Ligands Lymphocytes Lymphocytes T Monoclonal antibodies Peripheral blood mononuclear cells Pharmacology Psoriatic arthritis Rheumatoid arthritis Signal transduction
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