Acute Exposure of Zebrafish (Danio rerio) to the Next-Generation Perfluoroalkyl Substance, Perfluoroethylcyclohexanesulfonate, Shows Similar Effects as Legacy Substances
Perfluoroethylcyclohexanesulfonate (PFECHS) is an emerging perfluoroalkyl substance (PFAS) that has been considered a potential replacement for perfluorooctanesulfonic acid (PFOS). However, there is little information characterizing the toxic potency of PFECHS to zebrafish embryos and its potential...
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| Veröffentlicht in: | Environmental science & technology 2023-03, Vol.57 (10), p.4199-4207 |
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| creator | Mahoney, Hannah Cantin, Jenna Rybchuk, Josephine Xie, Yuwei Giesy, John P. Brinkmann, Markus |
| description | Perfluoroethylcyclohexanesulfonate (PFECHS) is an emerging perfluoroalkyl substance (PFAS) that has been considered a potential replacement for perfluorooctanesulfonic acid (PFOS). However, there is little information characterizing the toxic potency of PFECHS to zebrafish embryos and its potential for effects in aquatic environments. This study assessed toxic potency of PFECHS in vivo during both acute (96-hour postfertilization) and chronic (21-day posthatch) exposures and tested concentrations of PFECHS from 500 ng/L to 2 mg/L. PFECHS was less likely to cause mortalities than PFOS for both the acute and chronic experiments based on previously published values for PFOS exposure, but exposure resulted in a similar incidence of deformities. Exposure to PFECHS also resulted in significantly increased abundance of transcripts of peroxisome proliferator activated receptor alpha (pparα), cytochrome p450 1a1 (cyp1a1), and apolipoprotein IV (apoaIV) at concentrations nearing those of environmental relevance. Overall, these results provide further insight into the safety of an emerging PFAS alternative in the aquatic environment and raise awareness that previously considered “safer” alternatives may show similar effects as legacy PFASs. |
| doi_str_mv | 10.1021/acs.est.2c08463 |
| format | Article |
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Sci. Technol</addtitle><date>2023-03-14</date><risdate>2023</risdate><volume>57</volume><issue>10</issue><spage>4199</spage><epage>4207</epage><pages>4199-4207</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><abstract>Perfluoroethylcyclohexanesulfonate (PFECHS) is an emerging perfluoroalkyl substance (PFAS) that has been considered a potential replacement for perfluorooctanesulfonic acid (PFOS). However, there is little information characterizing the toxic potency of PFECHS to zebrafish embryos and its potential for effects in aquatic environments. This study assessed toxic potency of PFECHS in vivo during both acute (96-hour postfertilization) and chronic (21-day posthatch) exposures and tested concentrations of PFECHS from 500 ng/L to 2 mg/L. PFECHS was less likely to cause mortalities than PFOS for both the acute and chronic experiments based on previously published values for PFOS exposure, but exposure resulted in a similar incidence of deformities. Exposure to PFECHS also resulted in significantly increased abundance of transcripts of peroxisome proliferator activated receptor alpha (pparα), cytochrome p450 1a1 (cyp1a1), and apolipoprotein IV (apoaIV) at concentrations nearing those of environmental relevance. Overall, these results provide further insight into the safety of an emerging PFAS alternative in the aquatic environment and raise awareness that previously considered “safer” alternatives may show similar effects as legacy PFASs.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>36854060</pmid><doi>10.1021/acs.est.2c08463</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3518-149X</orcidid><orcidid>https://orcid.org/0000-0003-1931-9962</orcidid><orcidid>https://orcid.org/0000-0002-4985-263X</orcidid><orcidid>https://orcid.org/0000-0001-5652-6413</orcidid></addata></record> |
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| ispartof | Environmental science & technology, 2023-03, Vol.57 (10), p.4199-4207 |
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| source | MEDLINE; ACS Publications |
| subjects | Alkanesulfonic Acids - toxicity Animals Apolipoproteins Aquatic environment Biocompatibility Contaminants in Aquatic and Terrestrial Environments Cytochrome P450 Cytochromes P450 Danio rerio Embryos Exposure Fluorocarbons - analysis Fluorocarbons - toxicity In vivo methods and tests Perfluoro compounds Perfluoroalkyl & polyfluoroalkyl substances Perfluorochemicals Perfluorooctane sulfonic acid Sulfonic Acids - toxicity Water Pollutants, Chemical - analysis Water Pollutants, Chemical - toxicity Zebrafish |
| title | Acute Exposure of Zebrafish (Danio rerio) to the Next-Generation Perfluoroalkyl Substance, Perfluoroethylcyclohexanesulfonate, Shows Similar Effects as Legacy Substances |
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