Oral cancer in Australia: Rising incidence and worsening mortality
Background Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, 5‐year survival rates remain around 50%, primarily due to late presentation of ad...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2023-04, Vol.52 (4), p.328-334 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Sun, Aria Sharma, Dileep Choi, Siu‐Wai Ramamurthy, Poornima Thomson, Peter |
| description | Background
Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, 5‐year survival rates remain around 50%, primarily due to late presentation of advanced stage disease. Whilst low socio‐economic status, regional and remote location and indigenous status are associated with head and neck cancer in general, detailed incidence and demographic data for oral SCC in Australia are limited. This study aimed to characterise the Queensland population at risk of oral SCC development.
Methods
Following ethical approval, the Queensland Cancer Register (QCR) dataset was analysed to determine patterns of incidence, anonymised patient demographics, clinical presentation and outcome data for oral SCC cases diagnosed between 1982 and 2018.
Results
Data from 9887 patients were obtained. Mean age at diagnosis was 64.55 years, with a male‐to‐female ratio of 2.51:1; males were diagnosed at a younger age (p |
| doi_str_mv | 10.1111/jop.13421 |
| format | Article |
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Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, 5‐year survival rates remain around 50%, primarily due to late presentation of advanced stage disease. Whilst low socio‐economic status, regional and remote location and indigenous status are associated with head and neck cancer in general, detailed incidence and demographic data for oral SCC in Australia are limited. This study aimed to characterise the Queensland population at risk of oral SCC development.
Methods
Following ethical approval, the Queensland Cancer Register (QCR) dataset was analysed to determine patterns of incidence, anonymised patient demographics, clinical presentation and outcome data for oral SCC cases diagnosed between 1982 and 2018.
Results
Data from 9887 patients were obtained. Mean age at diagnosis was 64.55 years, with a male‐to‐female ratio of 2.51:1; males were diagnosed at a younger age (p < 0.001). At study census date, 59% of patients had died, with females demonstrating longer mean survival (p < 0.001). Clinicopathological data confirmed that SCC most commonly arose from tongue sites (49%) and, whilst tumours were predominantly moderately differentiated in nature (63%), patients with poorly differentiated carcinomas exhibited shortest survival times (p < 0.05). Over the 36‐year study period, the number of diagnoses increased 4.49‐fold, whilst the number of deaths increased 19.14‐fold.
Conclusion
Oral SCC poses a significant and growing healthcare problem in Queensland. In the absence of national screening, characterising the high‐risk oral SCC population facilitates pragmatic opportunities to raise disease awareness, to deliver targeted screening and effective primary prevention strategies, and to provide early interventional treatment intervention to reduce disease mortality and morbidity.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13421</identifier><identifier>PMID: 36852511</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Demography ; Disease prevention ; Female ; Head & neck cancer ; Head and Neck Neoplasms ; Humans ; Incidence ; Male ; Middle Aged ; Morbidity ; Mortality ; Mouth Neoplasms - epidemiology ; Oral cancer ; oral squamous cell carcinoma ; Patients ; Risk Factors ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck</subject><ispartof>Journal of oral pathology & medicine, 2023-04, Vol.52 (4), p.328-334</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-8b43ce973dc9f8860e5a4b5dfc3d4986876b8689e7a0246b5cee7a87ba95e1ec3</citedby><cites>FETCH-LOGICAL-c3881-8b43ce973dc9f8860e5a4b5dfc3d4986876b8689e7a0246b5cee7a87ba95e1ec3</cites><orcidid>0000-0002-2007-7975 ; 0000-0002-8189-790X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.13421$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.13421$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36852511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Aria</creatorcontrib><creatorcontrib>Sharma, Dileep</creatorcontrib><creatorcontrib>Choi, Siu‐Wai</creatorcontrib><creatorcontrib>Ramamurthy, Poornima</creatorcontrib><creatorcontrib>Thomson, Peter</creatorcontrib><title>Oral cancer in Australia: Rising incidence and worsening mortality</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background
Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, 5‐year survival rates remain around 50%, primarily due to late presentation of advanced stage disease. Whilst low socio‐economic status, regional and remote location and indigenous status are associated with head and neck cancer in general, detailed incidence and demographic data for oral SCC in Australia are limited. This study aimed to characterise the Queensland population at risk of oral SCC development.
Methods
Following ethical approval, the Queensland Cancer Register (QCR) dataset was analysed to determine patterns of incidence, anonymised patient demographics, clinical presentation and outcome data for oral SCC cases diagnosed between 1982 and 2018.
Results
Data from 9887 patients were obtained. Mean age at diagnosis was 64.55 years, with a male‐to‐female ratio of 2.51:1; males were diagnosed at a younger age (p < 0.001). At study census date, 59% of patients had died, with females demonstrating longer mean survival (p < 0.001). Clinicopathological data confirmed that SCC most commonly arose from tongue sites (49%) and, whilst tumours were predominantly moderately differentiated in nature (63%), patients with poorly differentiated carcinomas exhibited shortest survival times (p < 0.05). Over the 36‐year study period, the number of diagnoses increased 4.49‐fold, whilst the number of deaths increased 19.14‐fold.
Conclusion
Oral SCC poses a significant and growing healthcare problem in Queensland. In the absence of national screening, characterising the high‐risk oral SCC population facilitates pragmatic opportunities to raise disease awareness, to deliver targeted screening and effective primary prevention strategies, and to provide early interventional treatment intervention to reduce disease mortality and morbidity.</description><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Demography</subject><subject>Disease prevention</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Oral cancer</subject><subject>oral squamous cell carcinoma</subject><subject>Patients</subject><subject>Risk Factors</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlYP_gFZ8KKHbZNNNpt4q8VPChXR85LNzkrKfpnsUvrvTd3qQTCHyfDOMy_Di9A5wVPi32zdtFNCWUQO0JhwjEOcEHaIxlhiFkYxiUboxLk1xiShjByjEeUi9joZo9uVVWWgVa3BBqYO5r3rvGLUTfBqnKk_vKhNDn4eqDoPNo11UO_0qrGdB7vtKToqVOngbP9P0Pv93dviMVyuHp4W82WoqRAkFBmjGmRCcy0LITiGWLEszgtNcyYFFwnPfJWQKBwxnsUafCuSTMkYCGg6QVeDb2ubzx5cl1bGaShLVUPTuzRKBE44ZzLy6OUfdN30tvbXeUoyyQiNd9T1QGnbOGehSFtrKmW3KcHpLli_1abfwXr2Yu_YZxXkv-RPkh6YDcDGlLD93yl9Xr0Mll8Y-4DG</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Sun, Aria</creator><creator>Sharma, Dileep</creator><creator>Choi, Siu‐Wai</creator><creator>Ramamurthy, Poornima</creator><creator>Thomson, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2007-7975</orcidid><orcidid>https://orcid.org/0000-0002-8189-790X</orcidid></search><sort><creationdate>202304</creationdate><title>Oral cancer in Australia: Rising incidence and worsening mortality</title><author>Sun, Aria ; Sharma, Dileep ; Choi, Siu‐Wai ; Ramamurthy, Poornima ; Thomson, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-8b43ce973dc9f8860e5a4b5dfc3d4986876b8689e7a0246b5cee7a87ba95e1ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Demography</topic><topic>Disease prevention</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Oral cancer</topic><topic>oral squamous cell carcinoma</topic><topic>Patients</topic><topic>Risk Factors</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Aria</creatorcontrib><creatorcontrib>Sharma, Dileep</creatorcontrib><creatorcontrib>Choi, Siu‐Wai</creatorcontrib><creatorcontrib>Ramamurthy, Poornima</creatorcontrib><creatorcontrib>Thomson, Peter</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Aria</au><au>Sharma, Dileep</au><au>Choi, Siu‐Wai</au><au>Ramamurthy, Poornima</au><au>Thomson, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral cancer in Australia: Rising incidence and worsening mortality</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2023-04</date><risdate>2023</risdate><volume>52</volume><issue>4</issue><spage>328</spage><epage>334</epage><pages>328-334</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background
Oral cancer, predominantly squamous cell carcinoma (SCC), is a lethal and deforming disease of rising incidence. Although largely preventable by eliminating harmful tobacco and alcohol risk factor behaviour, 5‐year survival rates remain around 50%, primarily due to late presentation of advanced stage disease. Whilst low socio‐economic status, regional and remote location and indigenous status are associated with head and neck cancer in general, detailed incidence and demographic data for oral SCC in Australia are limited. This study aimed to characterise the Queensland population at risk of oral SCC development.
Methods
Following ethical approval, the Queensland Cancer Register (QCR) dataset was analysed to determine patterns of incidence, anonymised patient demographics, clinical presentation and outcome data for oral SCC cases diagnosed between 1982 and 2018.
Results
Data from 9887 patients were obtained. Mean age at diagnosis was 64.55 years, with a male‐to‐female ratio of 2.51:1; males were diagnosed at a younger age (p < 0.001). At study census date, 59% of patients had died, with females demonstrating longer mean survival (p < 0.001). Clinicopathological data confirmed that SCC most commonly arose from tongue sites (49%) and, whilst tumours were predominantly moderately differentiated in nature (63%), patients with poorly differentiated carcinomas exhibited shortest survival times (p < 0.05). Over the 36‐year study period, the number of diagnoses increased 4.49‐fold, whilst the number of deaths increased 19.14‐fold.
Conclusion
Oral SCC poses a significant and growing healthcare problem in Queensland. In the absence of national screening, characterising the high‐risk oral SCC population facilitates pragmatic opportunities to raise disease awareness, to deliver targeted screening and effective primary prevention strategies, and to provide early interventional treatment intervention to reduce disease mortality and morbidity.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36852511</pmid><doi>10.1111/jop.13421</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2007-7975</orcidid><orcidid>https://orcid.org/0000-0002-8189-790X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Demography Disease prevention Female Head & neck cancer Head and Neck Neoplasms Humans Incidence Male Middle Aged Morbidity Mortality Mouth Neoplasms - epidemiology Oral cancer oral squamous cell carcinoma Patients Risk Factors Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck |
| title | Oral cancer in Australia: Rising incidence and worsening mortality |
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